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- W2782036083 abstract "Introduction: Structural alterations of the apical cell membrane and the microvillus cyto skeleton may contribute to increased transcellular permeability in Crohn's disease (CD) and ulcerative colitis (UC). The aim of this study was to investigate the distribution of su crase-isomaltase (S-I), a disaccharidase of the apical brush border, and villin (V), a pro tein of the microvillus cytoskeleton, in normal enterocytes (NE) and enterocytes with rapid antigen uptake into the cytosol (RACE) from healthy controis (HC) or patients with CD or UC.Methods: Labeling densities (LD) of S-I- and V-binding antibodies were deter mined by immunoelectron microscopy in CD [ileum (il), n = 5] and UC [colon (co), n = 5] and was compared to HC (il, n=5j co, n= 5). Wilcoxon U-test was used for statistical anal ysis with p < 0.05 considered to be significant. Results: LD of S-I was significantly de creased in NE of CD compared to HC-il (p < 0.01) and in RACE of CD compared to the corresponding NE (p < 0.01). In UC, LD of S-I was significantly higher in NE compared to both HC-co (p < 0.01) and RACE (p < 0.01). In CD and UC, LD for V was significantly de creased in NE compared to HC-il and HC-co (P<0.05) and in RACE compared to NE (p < 0.01). Conclusion: These results support the thesis of a structural alteration of intesti nal enterocytes in CD and UC. Altered epithelia may increase (transcellular) intestinal permeability, which may result in an increased uptake of luminal antigens in CD and uc." @default.
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- W2782036083 date "2001-01-01" @default.
- W2782036083 modified "2023-10-17" @default.
- W2782036083 title "Strukturelle Veranderungen der apikalen Zellmembran in Enterozyten bei Morbus Crohn und Colitis ulcerosa Structural alterations of the apical membrane and microvillus cytoskeleton in enterocytes of Crohn's disease and ulcerative colitis" @default.
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