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• W2782078120 abstract "Late-stage oxidation using liver microsomes was applied to phosphodiesterase 2 inhibitor 1 to reduce its clearance by cytochrome P450 enzymes, introduce renal clearance, and minimize the risk for victim drug-drug interactions. This approach yielded PF-06815189 (2) with improved physicochemical properties and a mixed metabolic profile. This example highlights the importance of C-H diversification methods to drug discovery." @default.
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• W2782078120 date "2018-01-30" @default.
• W2782078120 modified "2023-10-13" @default.
• W2782078120 title "Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189" @default.
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• W2782078120 doi "https://doi.org/10.1021/acsmedchemlett.7b00343" @default.
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