Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782081756> ?p ?o ?g. }
- W2782081756 abstract "Abstract Hypothalamic inflammation is a key component of acute sickness behavior and cachexia, yet mechanisms of inflammatory signaling in the central nervous system remain unclear. We assessed the role of TRIF signaling in acute inflammation (lipopolysaccharide (LPS) challenge) and in a chronic inflammatory state (cancer cachexia). TRIFKO mice resisted anorexia and weight loss after peripheral (intraperitoneal, IP) or central (intracerebroventricular, ICV) LPS challenge and in a model of pancreatic cancer cachexia. Compared to WT mice, TRIFKO mice showed attenuated upregulation of Il6, Ccl2, Ccl5, Cxcl1, Cxcl2, and Cxcl10 in the hypothalamus after IP LPS treatment, as well as attenuated microglial activation and neutrophil infiltration into the brain after ICV LPS treatment. Our results show that TRIF is an important inflammatory signaling mediator of sickness behavior and cachexia and presents a novel therapeutic target for these conditions." @default.
- W2782081756 created "2018-01-12" @default.
- W2782081756 creator A5000850327 @default.
- W2782081756 creator A5002708668 @default.
- W2782081756 creator A5014492097 @default.
- W2782081756 creator A5015950566 @default.
- W2782081756 creator A5048749219 @default.
- W2782081756 creator A5051940069 @default.
- W2782081756 date "2017-12-11" @default.
- W2782081756 modified "2023-10-18" @default.
- W2782081756 title "“TRIF is a key inflammatory mediator of acute sickness behavior and cancer cachexia”" @default.
- W2782081756 cites W1963903389 @default.
- W2782081756 cites W1964846273 @default.
- W2782081756 cites W1965826182 @default.
- W2782081756 cites W1965971815 @default.
- W2782081756 cites W1966350956 @default.
- W2782081756 cites W1980288122 @default.
- W2782081756 cites W1982833571 @default.
- W2782081756 cites W1985718159 @default.
- W2782081756 cites W1989199068 @default.
- W2782081756 cites W1996734072 @default.
- W2782081756 cites W2003064100 @default.
- W2782081756 cites W2005609308 @default.
- W2782081756 cites W2008869575 @default.
- W2782081756 cites W2016341941 @default.
- W2782081756 cites W2016366890 @default.
- W2782081756 cites W2017883909 @default.
- W2782081756 cites W2019605946 @default.
- W2782081756 cites W2020098595 @default.
- W2782081756 cites W2023074871 @default.
- W2782081756 cites W2023634700 @default.
- W2782081756 cites W2031170591 @default.
- W2782081756 cites W2033218360 @default.
- W2782081756 cites W2033797333 @default.
- W2782081756 cites W2034137314 @default.
- W2782081756 cites W2039016375 @default.
- W2782081756 cites W2053488806 @default.
- W2782081756 cites W2054275187 @default.
- W2782081756 cites W2055390072 @default.
- W2782081756 cites W2059433193 @default.
- W2782081756 cites W2062036262 @default.
- W2782081756 cites W2064702122 @default.
- W2782081756 cites W2084726673 @default.
- W2782081756 cites W2117066780 @default.
- W2782081756 cites W2120031234 @default.
- W2782081756 cites W2121347099 @default.
- W2782081756 cites W2122965536 @default.
- W2782081756 cites W2130421043 @default.
- W2782081756 cites W2133105045 @default.
- W2782081756 cites W2139827430 @default.
- W2782081756 cites W2145280166 @default.
- W2782081756 cites W2150364761 @default.
- W2782081756 cites W2151718282 @default.
- W2782081756 cites W2157191168 @default.
- W2782081756 cites W2177984400 @default.
- W2782081756 cites W2189988755 @default.
- W2782081756 cites W2417501132 @default.
- W2782081756 cites W2466026988 @default.
- W2782081756 cites W2482783327 @default.
- W2782081756 cites W2486310606 @default.
- W2782081756 cites W2737050825 @default.
- W2782081756 doi "https://doi.org/10.1101/232280" @default.
- W2782081756 hasPublicationYear "2017" @default.
- W2782081756 type Work @default.
- W2782081756 sameAs 2782081756 @default.
- W2782081756 citedByCount "0" @default.
- W2782081756 crossrefType "posted-content" @default.
- W2782081756 hasAuthorship W2782081756A5000850327 @default.
- W2782081756 hasAuthorship W2782081756A5002708668 @default.
- W2782081756 hasAuthorship W2782081756A5014492097 @default.
- W2782081756 hasAuthorship W2782081756A5015950566 @default.
- W2782081756 hasAuthorship W2782081756A5048749219 @default.
- W2782081756 hasAuthorship W2782081756A5051940069 @default.
- W2782081756 hasBestOaLocation W27820817561 @default.
- W2782081756 hasConcept C121608353 @default.
- W2782081756 hasConcept C126322002 @default.
- W2782081756 hasConcept C13373296 @default.
- W2782081756 hasConcept C134018914 @default.
- W2782081756 hasConcept C136449434 @default.
- W2782081756 hasConcept C138906646 @default.
- W2782081756 hasConcept C203014093 @default.
- W2782081756 hasConcept C2107291 @default.
- W2782081756 hasConcept C2776709828 @default.
- W2782081756 hasConcept C2776914184 @default.
- W2782081756 hasConcept C2777704314 @default.
- W2782081756 hasConcept C2778654693 @default.
- W2782081756 hasConcept C2778754761 @default.
- W2782081756 hasConcept C2779830541 @default.
- W2782081756 hasConcept C43929388 @default.
- W2782081756 hasConcept C71924100 @default.
- W2782081756 hasConcept C8891405 @default.
- W2782081756 hasConcept C96525457 @default.
- W2782081756 hasConceptScore W2782081756C121608353 @default.
- W2782081756 hasConceptScore W2782081756C126322002 @default.
- W2782081756 hasConceptScore W2782081756C13373296 @default.
- W2782081756 hasConceptScore W2782081756C134018914 @default.
- W2782081756 hasConceptScore W2782081756C136449434 @default.
- W2782081756 hasConceptScore W2782081756C138906646 @default.
- W2782081756 hasConceptScore W2782081756C203014093 @default.
- W2782081756 hasConceptScore W2782081756C2107291 @default.