FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782097634> ?p ?o ?g. }

• W2782097634 abstract "Abstract Transfer RNAs (tRNAs) are a central component for the biological synthesis of proteins, and they are among the most highly conserved and frequently transcribed genes in all living things. Despite their clear significance for fundamental cellular processes, the forces governing tRNA evolution are poorly understood. We present evidence that transcription-associated mutagenesis and strong purifying selection are key determinants of patterns of sequence variation within and surrounding tRNA genes in humans and diverse model organisms. Remarkably, the mutation rate at broadly expressed cytosolic tRNA loci is likely between seven and ten times greater than the nuclear genome average. Furthermore, evolutionary analyses provide strong evidence that tRNA genes, but not their flanking sequences, experience strong purifying selection, acting against this elevated mutation rate. We also find a strong correlation between tRNA expression levels and the mutation rates in their immediate flanking regions, suggesting a simple new method for estimating individual tRNA gene activity. Collectively, this study illuminates the extreme competing forces in tRNA gene evolution, and implies that mutations at tRNA loci contribute disproportionately to mutational load and have unexplored fitness consequences in human populations. Significance Statement While transcription-associated mutagenesis (TAM) has been demonstrated for protein coding genes, its implications in shaping genome structure at transfer RNA (tRNA) loci in metazoans have not been fully appreciated. We show that cytosolic tRNAs are a striking example of TAM because of their variable rates of transcription, well-defined boundaries and internal promoter sequences. tRNA loci have a mutation rate approximately seven-to tenfold greater than the genome-wide average, and these mutations are consistent with signatures of TAM. These observations indicate that tRNA loci are disproportionately large contributors to mutational load in the human genome. Furthermore, the correlations between tRNA locus variation and transcription implicate that prediction of tRNA gene expression based on sequence variation data is possible." @default.
• W2782097634 created "2018-01-12" @default.
• W2782097634 creator A5000134895 @default.
• W2782097634 creator A5013663850 @default.
• W2782097634 creator A5016860853 @default.
• W2782097634 creator A5028393837 @default.
• W2782097634 creator A5063542140 @default.
• W2782097634 creator A5076593250 @default.
• W2782097634 date "2017-12-06" @default.
• W2782097634 modified "2023-09-23" @default.
• W2782097634 title "Transfer RNA genes experience exceptionally elevated mutation rates" @default.
• W2782097634 cites W1494075612 @default.
• W2782097634 cites W1539101364 @default.
• W2782097634 cites W1544691147 @default.
• W2782097634 cites W1963924607 @default.
• W2782097634 cites W1966413612 @default.
• W2782097634 cites W1974956115 @default.
• W2782097634 cites W1975441632 @default.
• W2782097634 cites W1975833723 @default.
• W2782097634 cites W1978189157 @default.
• W2782097634 cites W1983859619 @default.
• W2782097634 cites W1984783168 @default.
• W2782097634 cites W2000149256 @default.
• W2782097634 cites W2008358682 @default.
• W2782097634 cites W2015942563 @default.
• W2782097634 cites W2039959586 @default.
• W2782097634 cites W2043745733 @default.
• W2782097634 cites W2045529026 @default.
• W2782097634 cites W2049424828 @default.
• W2782097634 cites W2054453787 @default.
• W2782097634 cites W2076154138 @default.
• W2782097634 cites W2084622414 @default.
• W2782097634 cites W2085428320 @default.
• W2782097634 cites W2087627409 @default.
• W2782097634 cites W2087846512 @default.
• W2782097634 cites W2091860339 @default.
• W2782097634 cites W2102904139 @default.
• W2782097634 cites W2104549677 @default.
• W2782097634 cites W2108138064 @default.
• W2782097634 cites W2108871359 @default.
• W2782097634 cites W2109024885 @default.
• W2782097634 cites W2112132489 @default.
• W2782097634 cites W2114147818 @default.
• W2782097634 cites W2116640594 @default.
• W2782097634 cites W2119635233 @default.
• W2782097634 cites W2124320739 @default.
• W2782097634 cites W2127055349 @default.
• W2782097634 cites W2128016314 @default.
• W2782097634 cites W2134320468 @default.
• W2782097634 cites W2135663451 @default.
• W2782097634 cites W2139548742 @default.
• W2782097634 cites W2140822478 @default.
• W2782097634 cites W2142125232 @default.
• W2782097634 cites W2142504849 @default.
• W2782097634 cites W2145573047 @default.
• W2782097634 cites W2151464048 @default.
• W2782097634 cites W2155786005 @default.
• W2782097634 cites W2156234555 @default.
• W2782097634 cites W2163554913 @default.
• W2782097634 cites W2165608108 @default.
• W2782097634 cites W2166603832 @default.
• W2782097634 cites W2167852161 @default.
• W2782097634 cites W2168494144 @default.
• W2782097634 cites W2169212046 @default.
• W2782097634 cites W2198059726 @default.
• W2782097634 cites W2212660163 @default.
• W2782097634 cites W2223836536 @default.
• W2782097634 cites W2235159978 @default.
• W2782097634 cites W2259938310 @default.
• W2782097634 cites W2346143774 @default.
• W2782097634 cites W2393535458 @default.
• W2782097634 cites W2475184562 @default.
• W2782097634 cites W2526590774 @default.
• W2782097634 cites W2601286467 @default.
• W2782097634 cites W2613629789 @default.
• W2782097634 cites W2745150471 @default.
• W2782097634 cites W2751076435 @default.
• W2782097634 cites W4234887284 @default.
• W2782097634 doi "https://doi.org/10.1101/229906" @default.
• W2782097634 hasPublicationYear "2017" @default.
• W2782097634 type Work @default.
• W2782097634 sameAs 2782097634 @default.
• W2782097634 citedByCount "0" @default.
• W2782097634 crossrefType "posted-content" @default.
• W2782097634 hasAuthorship W2782097634A5000134895 @default.
• W2782097634 hasAuthorship W2782097634A5013663850 @default.
• W2782097634 hasAuthorship W2782097634A5016860853 @default.
• W2782097634 hasAuthorship W2782097634A5028393837 @default.
• W2782097634 hasAuthorship W2782097634A5063542140 @default.
• W2782097634 hasAuthorship W2782097634A5076593250 @default.
• W2782097634 hasBestOaLocation W27820976341 @default.
• W2782097634 hasConcept C104317684 @default.
• W2782097634 hasConcept C138885662 @default.
• W2782097634 hasConcept C141231307 @default.
• W2782097634 hasConcept C153957851 @default.
• W2782097634 hasConcept C16318435 @default.
• W2782097634 hasConcept C179926584 @default.
• W2782097634 hasConcept C41895202 @default.
• W2782097634 hasConcept C501734568 @default.
• W2782097634 hasConcept C54355233 @default.

• next