Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782106986> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2782106986 endingPage "4196" @default.
- W2782106986 startingPage "4196" @default.
- W2782106986 abstract "4196 The dietary agent, curcumin, has been shown to inhibit skin cancer cell proliferation and tumor formation. However, the effect of curcumin on normal human keratinocyte differentiation, proliferation and apoptosis has not been adequately studied. Involucrin (hINV) is a marker of keratinocyte differentiation. We show that curcumin suppresses the 12-O-tetradeconylphorbol-13-acetate (TPA)-dependent activation of hINV gene expression and that an AP1 site is required for this regulation. A nPKC, Ras, MEKK1, MEK3 signaling cascade that controls hINV expression by regulating AP1 factor function. Curcumin treatment inhibits nPKC-, Ras-and MEKK1-dependent activation of hINV promoter activity. We further show that curcumin treatment also regulates downstream events - specifically curcumin treatment suppresses the TPA-dependent increase in AP1 factor level and DNA binding. Moreover, the curcumin-dependent suppression of AP1 factor level requires proteasome function. In addition, curcumin treatment reduces cell number which is associated with a reduced cyclin A, D1, and E, and cdk1 levels. Curcumin treatment also suppresses Bcl-xL level, leading to reduced mitochondrial membrane potential, and increased cleavage of procaspase and PARP. These studies provide important insights regarding the potential mechanisms whereby curcumin may act as a chemopreventive agent in normal human epidermis." @default.
- W2782106986 created "2018-01-12" @default.
- W2782106986 creator A5000749676 @default.
- W2782106986 creator A5013153315 @default.
- W2782106986 date "2007-05-01" @default.
- W2782106986 modified "2023-09-24" @default.
- W2782106986 title "Curcumin suppresses AP1 factor-dependent differentiation and activates apoptosis in human epidermal keratinocytes" @default.
- W2782106986 hasPublicationYear "2007" @default.
- W2782106986 type Work @default.
- W2782106986 sameAs 2782106986 @default.
- W2782106986 citedByCount "0" @default.
- W2782106986 crossrefType "journal-article" @default.
- W2782106986 hasAuthorship W2782106986A5000749676 @default.
- W2782106986 hasAuthorship W2782106986A5013153315 @default.
- W2782106986 hasConcept C102280478 @default.
- W2782106986 hasConcept C104317684 @default.
- W2782106986 hasConcept C153911025 @default.
- W2782106986 hasConcept C185592680 @default.
- W2782106986 hasConcept C190283241 @default.
- W2782106986 hasConcept C202751555 @default.
- W2782106986 hasConcept C2777074287 @default.
- W2782106986 hasConcept C2778250585 @default.
- W2782106986 hasConcept C502942594 @default.
- W2782106986 hasConcept C55493867 @default.
- W2782106986 hasConcept C62478195 @default.
- W2782106986 hasConcept C86339819 @default.
- W2782106986 hasConcept C86803240 @default.
- W2782106986 hasConcept C95444343 @default.
- W2782106986 hasConceptScore W2782106986C102280478 @default.
- W2782106986 hasConceptScore W2782106986C104317684 @default.
- W2782106986 hasConceptScore W2782106986C153911025 @default.
- W2782106986 hasConceptScore W2782106986C185592680 @default.
- W2782106986 hasConceptScore W2782106986C190283241 @default.
- W2782106986 hasConceptScore W2782106986C202751555 @default.
- W2782106986 hasConceptScore W2782106986C2777074287 @default.
- W2782106986 hasConceptScore W2782106986C2778250585 @default.
- W2782106986 hasConceptScore W2782106986C502942594 @default.
- W2782106986 hasConceptScore W2782106986C55493867 @default.
- W2782106986 hasConceptScore W2782106986C62478195 @default.
- W2782106986 hasConceptScore W2782106986C86339819 @default.
- W2782106986 hasConceptScore W2782106986C86803240 @default.
- W2782106986 hasConceptScore W2782106986C95444343 @default.
- W2782106986 hasLocation W27821069861 @default.
- W2782106986 hasOpenAccess W2782106986 @default.
- W2782106986 hasPrimaryLocation W27821069861 @default.
- W2782106986 hasRelatedWork W1932468335 @default.
- W2782106986 hasRelatedWork W1977521071 @default.
- W2782106986 hasRelatedWork W2017813632 @default.
- W2782106986 hasRelatedWork W2043371357 @default.
- W2782106986 hasRelatedWork W2052369675 @default.
- W2782106986 hasRelatedWork W2075400378 @default.
- W2782106986 hasRelatedWork W2078351994 @default.
- W2782106986 hasRelatedWork W2080421246 @default.
- W2782106986 hasRelatedWork W2165040758 @default.
- W2782106986 hasRelatedWork W2417269926 @default.
- W2782106986 hasRelatedWork W2472904797 @default.
- W2782106986 hasRelatedWork W2765197261 @default.
- W2782106986 hasRelatedWork W2769020797 @default.
- W2782106986 hasRelatedWork W2793413224 @default.
- W2782106986 hasRelatedWork W2953174978 @default.
- W2782106986 hasRelatedWork W3080554350 @default.
- W2782106986 hasRelatedWork W3151434922 @default.
- W2782106986 hasRelatedWork W3156753382 @default.
- W2782106986 hasRelatedWork W3164950287 @default.
- W2782106986 hasRelatedWork W426734051 @default.
- W2782106986 hasVolume "67" @default.
- W2782106986 isParatext "false" @default.
- W2782106986 isRetracted "false" @default.
- W2782106986 magId "2782106986" @default.
- W2782106986 workType "article" @default.