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- W2782121288 abstract "Nuclear myosin 1c (NM1) associates with RNA polymerases and is a partner in the chromatin remodeling complex B-WICH. This complex, which also contains WSTF and SNF2h proteins, is involved in transcriptional regulation. We report herein that papillomavirus protein E2 binds to NM1 and co-precipitates with the WSTF and SNF2h proteins. Our data suggest that E2 associates with the cellular B-WICH complex through binding to NM1. E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. The cellular multifunctional protein Brd4 and beta-actin are also present in the NM1-E2 complex. NM1 downregulation by siRNA increases the replication of the BPV1 and HPV5 genomes but does not affect HPV18 genome replication. These results suggest that the B-WICH complex may play a role in the papillomavirus life cycle through NM1 and E2 protein interaction." @default.
- W2782121288 created "2018-01-12" @default.
- W2782121288 creator A5001676836 @default.
- W2782121288 creator A5030633060 @default.
- W2782121288 creator A5054034142 @default.
- W2782121288 date "2018-01-01" @default.
- W2782121288 modified "2023-10-18" @default.
- W2782121288 title "Nuclear myosin 1 associates with papillomavirus E2 regulatory protein and influences viral replication" @default.
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- W2782121288 doi "https://doi.org/10.1016/j.virol.2017.11.013" @default.
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- W2782121288 hasPublicationYear "2018" @default.
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