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• W2782202290 endingPage "47" @default.
• W2782202290 startingPage "33" @default.
• W2782202290 abstract "Increasing clinical evidence supports the implementation of genotyping for anti-hypertensive drug dosing and selection. Despite robust evidence gleaned from clinical trials, the translation of genotype guided therapy into clinical practice faces significant challenges. Challenges to implementation include the small effect size of individual variants and the polygenetic nature of antihypertensive drug response, a lack of expert consensus on dosing guidelines even without genetic information, and proper definition of major antihypertensive drug toxicities. Balancing clinical benefit with cost, while overcoming these challenges, remains crucial.This review presents the most impactful clinical trials and cohorts which continue to inform and guide future investigation. Variants were selected from among those identified in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR), the Genetic Epidemiology of Responses to Antihypertensives study (GERA), the Genetics of Drug Responsiveness in Essential Hypertension (GENRES) study, the SOPHIA study, the Milan Hypertension Pharmacogenomics of hydro-chlorothiazide (MIHYPHCTZ), the Campania Salute Network, the International Verapamil SR Trandolapril Study (INVEST), the Nordic Diltiazem (NORDIL) Study, GenHAT, and others.The polygenic nature of antihypertensive drug response is a major barrier to clinical implementation. Further studies examining clinical effectiveness are required to support broad-based implementation of genotype-based prescribing in medical practice." @default.
• W2782202290 created "2018-01-12" @default.
• W2782202290 creator A5011537086 @default.
• W2782202290 creator A5040735144 @default.
• W2782202290 creator A5067667442 @default.
• W2782202290 date "2018-01-02" @default.
• W2782202290 modified "2023-10-10" @default.
• W2782202290 title "Pharmacogenomic studies of hypertension: paving the way for personalized antihypertensive treatment" @default.
• W2782202290 cites W1943869117 @default.
• W2782202290 cites W1963857359 @default.
• W2782202290 cites W1966234202 @default.
• W2782202290 cites W1971253384 @default.
• W2782202290 cites W1982226699 @default.
• W2782202290 cites W1983526026 @default.
• W2782202290 cites W1986264879 @default.
• W2782202290 cites W1988167410 @default.
• W2782202290 cites W1988225240 @default.
• W2782202290 cites W1990777904 @default.
• W2782202290 cites W2000107920 @default.
• W2782202290 cites W2001629081 @default.
• W2782202290 cites W2003509258 @default.
• W2782202290 cites W2008226844 @default.
• W2782202290 cites W2013608721 @default.
• W2782202290 cites W2017560514 @default.
• W2782202290 cites W2018518015 @default.
• W2782202290 cites W2019860224 @default.
• W2782202290 cites W2027496500 @default.
• W2782202290 cites W2028169010 @default.
• W2782202290 cites W2029706261 @default.
• W2782202290 cites W2041407082 @default.
• W2782202290 cites W2041469442 @default.
• W2782202290 cites W2042906575 @default.
• W2782202290 cites W2050697524 @default.
• W2782202290 cites W2056367362 @default.
• W2782202290 cites W2057419867 @default.
• W2782202290 cites W2058159909 @default.
• W2782202290 cites W2063987953 @default.
• W2782202290 cites W2074214145 @default.
• W2782202290 cites W2078118484 @default.
• W2782202290 cites W2078481267 @default.
• W2782202290 cites W2078491345 @default.
• W2782202290 cites W2081059560 @default.
• W2782202290 cites W2084903435 @default.
• W2782202290 cites W2085622221 @default.
• W2782202290 cites W2101605059 @default.
• W2782202290 cites W2102622802 @default.
• W2782202290 cites W2102804770 @default.
• W2782202290 cites W2105318826 @default.
• W2782202290 cites W2107139378 @default.
• W2782202290 cites W2108182085 @default.
• W2782202290 cites W2108656183 @default.
• W2782202290 cites W2111437367 @default.
• W2782202290 cites W2114476310 @default.
• W2782202290 cites W2118194784 @default.
• W2782202290 cites W2119117615 @default.
• W2782202290 cites W2120469225 @default.
• W2782202290 cites W2120798274 @default.
• W2782202290 cites W2126125759 @default.
• W2782202290 cites W2127752492 @default.
• W2782202290 cites W2127755983 @default.
• W2782202290 cites W2128170458 @default.
• W2782202290 cites W2129254992 @default.
• W2782202290 cites W2129869606 @default.
• W2782202290 cites W2133416234 @default.
• W2782202290 cites W2134149091 @default.
• W2782202290 cites W2134881214 @default.
• W2782202290 cites W2136145230 @default.
• W2782202290 cites W2138120558 @default.
• W2782202290 cites W2138644139 @default.
• W2782202290 cites W2138838688 @default.
• W2782202290 cites W2141922205 @default.
• W2782202290 cites W2155320225 @default.
• W2782202290 cites W2160188164 @default.
• W2782202290 cites W2171077971 @default.
• W2782202290 cites W2204516462 @default.
• W2782202290 cites W2222537596 @default.
• W2782202290 cites W2261029592 @default.
• W2782202290 cites W2295597824 @default.
• W2782202290 cites W2298723330 @default.
• W2782202290 cites W2313235566 @default.
• W2782202290 cites W2337573400 @default.
• W2782202290 cites W2346702072 @default.
• W2782202290 cites W2437822687 @default.
• W2782202290 cites W2467620689 @default.
• W2782202290 cites W2519445944 @default.
• W2782202290 cites W2519483107 @default.
• W2782202290 cites W2546010425 @default.
• W2782202290 cites W2554601476 @default.
• W2782202290 cites W2556167715 @default.
• W2782202290 cites W2559228560 @default.
• W2782202290 cites W2574764194 @default.
• W2782202290 cites W2576620235 @default.
• W2782202290 cites W2580792129 @default.
• W2782202290 cites W2581452190 @default.
• W2782202290 cites W2581540297 @default.
• W2782202290 cites W2582461952 @default.
• W2782202290 cites W2587639270 @default.
• W2782202290 cites W2597078841 @default.

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