FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782206986> ?p ?o ?g. }

• W2782206986 endingPage "e0189498" @default.
• W2782206986 startingPage "e0189498" @default.
• W2782206986 abstract "Gene-level analysis of ImmunoChip or genome-wide association studies (GWAS) data has not been previously reported for systemic sclerosis (SSc, scleroderma). The objective of this study was to analyze genetic susceptibility loci in SSc at the gene level and to determine if the detected associations were shared in African-American and White populations, using data from ImmunoChip and GWAS genotyping studies. The White sample included 1833 cases and 3466 controls (956 cases and 2741 controls from the US and 877 cases and 725 controls from Spain) and the African American sample, 291 cases and 260 controls. In both Whites and African Americans, we performed a gene-level analysis that integrates association statistics in a gene possibly harboring multiple SNPs with weak effect on disease risk, using Versatile Gene-based Association Study (VEGAS) software. The SNP-level analysis was performed using PLINK v.1.07. We identified 4 novel candidate genes (STAT1, FCGR2C, NIPSNAP3B, and SCT) significantly associated and 4 genes (SERBP1, PINX1, TMEM175 and EXOC2) suggestively associated with SSc in the gene level analysis in White patients. As an exploratory analysis we compared the results on Whites with those from African Americans. Of previously established susceptibility genes identified in Whites, only TNFAIP3 was significant at the nominal level (p = 6.13x10-3) in African Americans in the gene-level analysis of the ImmunoChip data. Among the top suggestive novel genes identified in Whites based on the ImmunoChip data, FCGR2C and PINX1 were only nominally significant in African Americans (p = 0.016 and p = 0.028, respectively), while among the top novel genes identified in the gene-level analysis in African Americans, UNC5C (p = 5.57x10-4) and CLEC16A (p = 0.0463) were also nominally significant in Whites. We also present the gene-level analysis of SSc clinical and autoantibody phenotypes among Whites. Our findings need to be validated by independent studies, particularly due to the limited sample size of African Americans." @default.
• W2782206986 created "2018-01-12" @default.
• W2782206986 creator A5000524323 @default.
• W2782206986 creator A5009236113 @default.
• W2782206986 creator A5011654253 @default.
• W2782206986 creator A5012766878 @default.
• W2782206986 creator A5012863830 @default.
• W2782206986 creator A5017176146 @default.
• W2782206986 creator A5018494561 @default.
• W2782206986 creator A5021143095 @default.
• W2782206986 creator A5024950256 @default.
• W2782206986 creator A5026240805 @default.
• W2782206986 creator A5026553120 @default.
• W2782206986 creator A5028989565 @default.
• W2782206986 creator A5029945008 @default.
• W2782206986 creator A5031124240 @default.
• W2782206986 creator A5032437502 @default.
• W2782206986 creator A5041758416 @default.
• W2782206986 creator A5048784728 @default.
• W2782206986 creator A5049874561 @default.
• W2782206986 creator A5051206664 @default.
• W2782206986 creator A5058289564 @default.
• W2782206986 creator A5059206584 @default.
• W2782206986 creator A5061815657 @default.
• W2782206986 creator A5064296895 @default.
• W2782206986 creator A5066883334 @default.
• W2782206986 creator A5073269240 @default.
• W2782206986 creator A5077130479 @default.
• W2782206986 creator A5077624751 @default.
• W2782206986 creator A5079814924 @default.
• W2782206986 creator A5082248535 @default.
• W2782206986 creator A5085514391 @default.
• W2782206986 creator A5087128953 @default.
• W2782206986 creator A5089758720 @default.
• W2782206986 date "2018-01-02" @default.
• W2782206986 modified "2023-10-14" @default.
• W2782206986 title "Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations" @default.
• W2782206986 cites W1590687564 @default.
• W2782206986 cites W2003283154 @default.
• W2782206986 cites W2007205845 @default.
• W2782206986 cites W2059283420 @default.
• W2782206986 cites W2087005537 @default.
• W2782206986 cites W2093488156 @default.
• W2782206986 cites W2096674621 @default.
• W2782206986 cites W2102690320 @default.
• W2782206986 cites W2104914251 @default.
• W2782206986 cites W2110280725 @default.
• W2782206986 cites W2116107710 @default.
• W2782206986 cites W2118448966 @default.
• W2782206986 cites W2119544631 @default.
• W2782206986 cites W2120860816 @default.
• W2782206986 cites W2122167649 @default.
• W2782206986 cites W2142389531 @default.
• W2782206986 cites W2143205052 @default.
• W2782206986 cites W2151963525 @default.
• W2782206986 cites W2152858279 @default.
• W2782206986 cites W2155527455 @default.
• W2782206986 cites W2161633633 @default.
• W2782206986 cites W2167700091 @default.
• W2782206986 cites W2409570311 @default.
• W2782206986 cites W2418489903 @default.
• W2782206986 cites W2519645451 @default.
• W2782206986 cites W978978982 @default.
• W2782206986 doi "https://doi.org/10.1371/journal.pone.0189498" @default.
• W2782206986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5749683" @default.
• W2782206986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29293537" @default.
• W2782206986 hasPublicationYear "2018" @default.
• W2782206986 type Work @default.
• W2782206986 sameAs 2782206986 @default.
• W2782206986 citedByCount "20" @default.
• W2782206986 countsByYear W27822069862019 @default.
• W2782206986 countsByYear W27822069862020 @default.
• W2782206986 countsByYear W27822069862021 @default.
• W2782206986 countsByYear W27822069862022 @default.
• W2782206986 countsByYear W27822069862023 @default.
• W2782206986 crossrefType "journal-article" @default.
• W2782206986 hasAuthorship W2782206986A5000524323 @default.
• W2782206986 hasAuthorship W2782206986A5009236113 @default.
• W2782206986 hasAuthorship W2782206986A5011654253 @default.
• W2782206986 hasAuthorship W2782206986A5012766878 @default.
• W2782206986 hasAuthorship W2782206986A5012863830 @default.
• W2782206986 hasAuthorship W2782206986A5017176146 @default.
• W2782206986 hasAuthorship W2782206986A5018494561 @default.
• W2782206986 hasAuthorship W2782206986A5021143095 @default.
• W2782206986 hasAuthorship W2782206986A5024950256 @default.
• W2782206986 hasAuthorship W2782206986A5026240805 @default.
• W2782206986 hasAuthorship W2782206986A5026553120 @default.
• W2782206986 hasAuthorship W2782206986A5028989565 @default.
• W2782206986 hasAuthorship W2782206986A5029945008 @default.
• W2782206986 hasAuthorship W2782206986A5031124240 @default.
• W2782206986 hasAuthorship W2782206986A5032437502 @default.
• W2782206986 hasAuthorship W2782206986A5041758416 @default.
• W2782206986 hasAuthorship W2782206986A5048784728 @default.
• W2782206986 hasAuthorship W2782206986A5049874561 @default.
• W2782206986 hasAuthorship W2782206986A5051206664 @default.
• W2782206986 hasAuthorship W2782206986A5058289564 @default.
• W2782206986 hasAuthorship W2782206986A5059206584 @default.
• W2782206986 hasAuthorship W2782206986A5061815657 @default.

• next