Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782207711> ?p ?o ?g. }
- W2782207711 endingPage "7" @default.
- W2782207711 startingPage "1" @default.
- W2782207711 abstract "It has been shown that vanadyl trehalose could lower blood glucose but show mild toxicity to the stomach and intestine in diabetic Kunming mice. We analysed antioxidant levels, pro-inflammatory cytokine expression, apoptosis factors and intestinal microflora alteration to explore the mechanism of vanadyl trehalose toxicity in Kunming mice. The results revealed that oral administration of vanadyl trehalose at tested dose caused significant changes in oxidative stress factor (MDA levels elevated but SOD and T-AOC decreased), expression of inflammatory factor (IL-1β, COX-2, TNF-α and iNOS increased), and apoptosis factor (Bcl-2/Bax decreased and caspase-3 increased), and intestinal microflora dysbiosis (the number of Enterobacteriaceae and Enterococcus increased and Lactobacillus and Bifidobacterium decreased) relative to the control of Kunming mice. These results suggest that the toxic mechanisms of vanadyl trehalose on the stomach and intestine likely involve activation of the oxidative stress system, increased inflammatory response, promotion of apoptosis and the disruption of the normal intestinal microflora." @default.
- W2782207711 created "2018-01-12" @default.
- W2782207711 creator A5014695838 @default.
- W2782207711 creator A5015494947 @default.
- W2782207711 creator A5024268530 @default.
- W2782207711 creator A5025804419 @default.
- W2782207711 creator A5026216393 @default.
- W2782207711 creator A5050191122 @default.
- W2782207711 creator A5071690624 @default.
- W2782207711 creator A5087562271 @default.
- W2782207711 date "2018-04-01" @default.
- W2782207711 modified "2023-10-11" @default.
- W2782207711 title "Primary study on the toxic mechanism of vanadyl trehalose in Kunming mice" @default.
- W2782207711 cites W1521242547 @default.
- W2782207711 cites W1540285469 @default.
- W2782207711 cites W1571529930 @default.
- W2782207711 cites W1575233743 @default.
- W2782207711 cites W1876341852 @default.
- W2782207711 cites W1964227923 @default.
- W2782207711 cites W1972009654 @default.
- W2782207711 cites W1981743399 @default.
- W2782207711 cites W1984727899 @default.
- W2782207711 cites W1992801439 @default.
- W2782207711 cites W1996580858 @default.
- W2782207711 cites W2000859856 @default.
- W2782207711 cites W2009085082 @default.
- W2782207711 cites W2011774955 @default.
- W2782207711 cites W2020815959 @default.
- W2782207711 cites W2024796877 @default.
- W2782207711 cites W2035415120 @default.
- W2782207711 cites W2037681128 @default.
- W2782207711 cites W2045431788 @default.
- W2782207711 cites W2048171730 @default.
- W2782207711 cites W2048705168 @default.
- W2782207711 cites W2054286992 @default.
- W2782207711 cites W2064355163 @default.
- W2782207711 cites W2065906579 @default.
- W2782207711 cites W2075241312 @default.
- W2782207711 cites W2082865189 @default.
- W2782207711 cites W2104628289 @default.
- W2782207711 cites W2107277218 @default.
- W2782207711 cites W2109891536 @default.
- W2782207711 cites W2133998377 @default.
- W2782207711 cites W2137493244 @default.
- W2782207711 cites W2143378100 @default.
- W2782207711 cites W2166511586 @default.
- W2782207711 cites W2169330513 @default.
- W2782207711 cites W2220345983 @default.
- W2782207711 cites W2324390979 @default.
- W2782207711 cites W2394735664 @default.
- W2782207711 cites W2588264188 @default.
- W2782207711 cites W3007688448 @default.
- W2782207711 cites W4230268485 @default.
- W2782207711 cites W4293223234 @default.
- W2782207711 doi "https://doi.org/10.1016/j.yrtph.2017.12.025" @default.
- W2782207711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29305949" @default.
- W2782207711 hasPublicationYear "2018" @default.
- W2782207711 type Work @default.
- W2782207711 sameAs 2782207711 @default.
- W2782207711 citedByCount "5" @default.
- W2782207711 countsByYear W27822077112018 @default.
- W2782207711 countsByYear W27822077112019 @default.
- W2782207711 countsByYear W27822077112020 @default.
- W2782207711 countsByYear W27822077112023 @default.
- W2782207711 crossrefType "journal-article" @default.
- W2782207711 hasAuthorship W2782207711A5014695838 @default.
- W2782207711 hasAuthorship W2782207711A5015494947 @default.
- W2782207711 hasAuthorship W2782207711A5024268530 @default.
- W2782207711 hasAuthorship W2782207711A5025804419 @default.
- W2782207711 hasAuthorship W2782207711A5026216393 @default.
- W2782207711 hasAuthorship W2782207711A5050191122 @default.
- W2782207711 hasAuthorship W2782207711A5071690624 @default.
- W2782207711 hasAuthorship W2782207711A5087562271 @default.
- W2782207711 hasConcept C100544194 @default.
- W2782207711 hasConcept C178790620 @default.
- W2782207711 hasConcept C185592680 @default.
- W2782207711 hasConcept C190283241 @default.
- W2782207711 hasConcept C2776151105 @default.
- W2782207711 hasConcept C2777165150 @default.
- W2782207711 hasConcept C2778004101 @default.
- W2782207711 hasConcept C2778452849 @default.
- W2782207711 hasConcept C2779422922 @default.
- W2782207711 hasConcept C2780206646 @default.
- W2782207711 hasConcept C2780305828 @default.
- W2782207711 hasConcept C29730261 @default.
- W2782207711 hasConcept C539455810 @default.
- W2782207711 hasConcept C55493867 @default.
- W2782207711 hasConcept C86803240 @default.
- W2782207711 hasConcept C89423630 @default.
- W2782207711 hasConcept C98274493 @default.
- W2782207711 hasConceptScore W2782207711C100544194 @default.
- W2782207711 hasConceptScore W2782207711C178790620 @default.
- W2782207711 hasConceptScore W2782207711C185592680 @default.
- W2782207711 hasConceptScore W2782207711C190283241 @default.
- W2782207711 hasConceptScore W2782207711C2776151105 @default.
- W2782207711 hasConceptScore W2782207711C2777165150 @default.
- W2782207711 hasConceptScore W2782207711C2778004101 @default.
- W2782207711 hasConceptScore W2782207711C2778452849 @default.