FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782296916> ?p ?o ?g. }

• W2782296916 endingPage "20" @default.
• W2782296916 startingPage "13" @default.
• W2782296916 abstract "MicroRNA-93-5p (miR-93-5p) dysregulation has been reported in many types of human cancer. However, the collective effect of miR-93-5p in both lung adenocarcinoma and squamous cell carcinoma and the mechanism underlying miR-93-5p involvement in non-small cell lung cancer cells (NSCLC) is unknown. Herein, our purpose was to reveal the role and explain this mechanism, with the goal of contributing to the development of new diagnostic biomarkers and individualized therapeutic targets. We examined miR-93-5p expression in NSCLC specimens (including lung adenocarcinoma and squamous cell carcinoma) by qPCR. The effects of miR-93-5p inhibitor on proliferation, migration, and invasion of NSCLC cells were determined by MTT assay, colony formation assays, apoptosis assay, cell cycle assay and transwell chamber assays, respectively. The molecular mechanisms underlying these effects were investigated via dual luciferase reporter assay and western blotting. MiR-93-5p expression levels were significantly correlated with NSCLC patients overall survival rate. Cell proliferation, migration, and invasion were significantly inhibited by miR-93-5p down-regulation. Dual luciferase reporter assay demonstrated that miR-93-5p directly bound with the 3′-untranslated region of the tumor suppressor gene PTEN and RB1. MiR-93-5p is up-regulated in NSCLC and plays an oncogenic role by inhibiting PTEN and RB1, suggesting miR-93-5p may be a novel prognostic indicator and a therapeutic target in NSCLC." @default.
• W2782296916 created "2018-01-12" @default.
• W2782296916 creator A5015355465 @default.
• W2782296916 creator A5069394674 @default.
• W2782296916 creator A5071409579 @default.
• W2782296916 creator A5071596730 @default.
• W2782296916 creator A5079491978 @default.
• W2782296916 creator A5081222516 @default.
• W2782296916 creator A5088116210 @default.
• W2782296916 date "2018-03-01" @default.
• W2782296916 modified "2023-10-16" @default.
• W2782296916 title "MiR-93-5p up-regulation is involved in non-small cell lung cancer cells proliferation and migration and poor prognosis" @default.
• W2782296916 cites W1768367957 @default.
• W2782296916 cites W2007701714 @default.
• W2782296916 cites W2022233569 @default.
• W2782296916 cites W2031448803 @default.
• W2782296916 cites W2034423362 @default.
• W2782296916 cites W2053702192 @default.
• W2782296916 cites W2092706476 @default.
• W2782296916 cites W2099877079 @default.
• W2782296916 cites W2142954321 @default.
• W2782296916 cites W2145220982 @default.
• W2782296916 cites W2202628895 @default.
• W2782296916 cites W2235523093 @default.
• W2782296916 cites W2256104903 @default.
• W2782296916 cites W2272984102 @default.
• W2782296916 cites W2341117915 @default.
• W2782296916 cites W2591948158 @default.
• W2782296916 cites W2592311234 @default.
• W2782296916 cites W2596527793 @default.
• W2782296916 cites W2605054024 @default.
• W2782296916 doi "https://doi.org/10.1016/j.gene.2018.01.024" @default.
• W2782296916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29309884" @default.
• W2782296916 hasPublicationYear "2018" @default.
• W2782296916 type Work @default.
• W2782296916 sameAs 2782296916 @default.
• W2782296916 citedByCount "46" @default.
• W2782296916 countsByYear W27822969162018 @default.
• W2782296916 countsByYear W27822969162019 @default.
• W2782296916 countsByYear W27822969162020 @default.
• W2782296916 countsByYear W27822969162021 @default.
• W2782296916 countsByYear W27822969162022 @default.
• W2782296916 countsByYear W27822969162023 @default.
• W2782296916 crossrefType "journal-article" @default.
• W2782296916 hasAuthorship W2782296916A5015355465 @default.
• W2782296916 hasAuthorship W2782296916A5069394674 @default.
• W2782296916 hasAuthorship W2782296916A5071409579 @default.
• W2782296916 hasAuthorship W2782296916A5071596730 @default.
• W2782296916 hasAuthorship W2782296916A5079491978 @default.
• W2782296916 hasAuthorship W2782296916A5081222516 @default.
• W2782296916 hasAuthorship W2782296916A5088116210 @default.
• W2782296916 hasConcept C104317684 @default.
• W2782296916 hasConcept C11957725 @default.
• W2782296916 hasConcept C121608353 @default.
• W2782296916 hasConcept C137738243 @default.
• W2782296916 hasConcept C143998085 @default.
• W2782296916 hasConcept C145059251 @default.
• W2782296916 hasConcept C1491633281 @default.
• W2782296916 hasConcept C150194340 @default.
• W2782296916 hasConcept C161733203 @default.
• W2782296916 hasConcept C190283241 @default.
• W2782296916 hasConcept C2776256026 @default.
• W2782296916 hasConcept C2777609662 @default.
• W2782296916 hasConcept C2779013556 @default.
• W2782296916 hasConcept C2780783641 @default.
• W2782296916 hasConcept C2781182431 @default.
• W2782296916 hasConcept C29537977 @default.
• W2782296916 hasConcept C502942594 @default.
• W2782296916 hasConcept C54355233 @default.
• W2782296916 hasConcept C55493867 @default.
• W2782296916 hasConcept C62112901 @default.
• W2782296916 hasConcept C71924100 @default.
• W2782296916 hasConcept C86554907 @default.
• W2782296916 hasConcept C86803240 @default.
• W2782296916 hasConceptScore W2782296916C104317684 @default.
• W2782296916 hasConceptScore W2782296916C11957725 @default.
• W2782296916 hasConceptScore W2782296916C121608353 @default.
• W2782296916 hasConceptScore W2782296916C137738243 @default.
• W2782296916 hasConceptScore W2782296916C143998085 @default.
• W2782296916 hasConceptScore W2782296916C145059251 @default.
• W2782296916 hasConceptScore W2782296916C1491633281 @default.
• W2782296916 hasConceptScore W2782296916C150194340 @default.
• W2782296916 hasConceptScore W2782296916C161733203 @default.
• W2782296916 hasConceptScore W2782296916C190283241 @default.
• W2782296916 hasConceptScore W2782296916C2776256026 @default.
• W2782296916 hasConceptScore W2782296916C2777609662 @default.
• W2782296916 hasConceptScore W2782296916C2779013556 @default.
• W2782296916 hasConceptScore W2782296916C2780783641 @default.
• W2782296916 hasConceptScore W2782296916C2781182431 @default.
• W2782296916 hasConceptScore W2782296916C29537977 @default.
• W2782296916 hasConceptScore W2782296916C502942594 @default.
• W2782296916 hasConceptScore W2782296916C54355233 @default.
• W2782296916 hasConceptScore W2782296916C55493867 @default.
• W2782296916 hasConceptScore W2782296916C62112901 @default.
• W2782296916 hasConceptScore W2782296916C71924100 @default.
• W2782296916 hasConceptScore W2782296916C86554907 @default.
• W2782296916 hasConceptScore W2782296916C86803240 @default.
• W2782296916 hasLocation W27822969161 @default.

• next