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• W2782334951 abstract "Colon cancer (CC) is the third most common cancer worldwide. Emodin is an anthraquinone-active substance that has the ability to affect tumor progression. Our study aims to explore the effects and the relevant mechanism of emodin on the invasion and migration of CC in vitro and in vivo. In our study, we found that emodin inhibited the invasion and migration abilities of RKO cells and decreased the expression of matrix metalloproteinase-7 (MMP-7), MMP-9, and vascular endothelial growth factor (VEGF) in a dose-dependent manner. Further research suggested that emodin inhibited EMT by increasing the mRNA level of E-cadherin and decreasing the expression of N-cadherin, Snail, and β-catenin. Emodin also significantly inhibited the activation of the Wnt/β-catenin signaling pathway by downregulating the expression of related downstream target genes, including TCF4, cyclin D1, and c-Myc. A Wnt/β-catenin signaling pathway agonist abolished the effect of emodin on EMT and cell mobility, suggesting that emodin exerted its regulating role through the Wnt/β-catenin pathway. The CC xenograft model was established to study the antitumor efficiency of emodin in vivo. The in vivo study further demonstrated that emodin (40 mg/kg) suppressed tumor growth by inhibiting EMT via the Wnt/β-catenin signaling pathway in vivo. Taken together, we suggest that emodin inhibits the invasion and migration of CC cells in vitro and in vivo by blocking EMT, which is related with the inhibition of the Wnt/β-catenin signaling pathway.An erratum for this article has been published in Oncology Research, Volume 28, Number 6, pp.681-682 (https://www.ingentaconnect.com/contentone/cog/or/2021/00000028/00000006/art00010). Note that an updated article PDF will be delivered from this page further to the issuing of the erratum." @default.
• W2782334951 created "2018-01-12" @default.
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• W2782334951 date "2019-02-05" @default.
• W2782334951 modified "2023-10-15" @default.
• W2782334951 title "Emodin Inhibits Colon Cancer Cell Invasion and Migration by Suppressing Epithelial‐Mesenchymal Transition via the Wnt/β-Catenin Pathway" @default.
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• W2782334951 doi "https://doi.org/10.3727/096504018x15150662230295" @default.
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