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• W2782364694 abstract "Mechanisms of mutation upregulated by stress responses have been described in several organisms from bacteria to human. These mechanisms might accelerate genetic change specifically when cells are maladapted to their environment. Stress-induced mutation mechanisms differ in their genetic requirements from mutation in growing cells, occurring by different mechanisms in different assay systems, but having in common a requirement for the induction of stress-responses. Here, we review progress in two areas relevant to stress-response-dependent mutagenic DNA break repair mechanisms in Escherichia coli. First, we review evidence that relates mutation to transcription. This connection might allow mutagenesis in transcribed regions, including those relevant to any stress being experienced, opening the possibility that mutations could be targeted to regions where mutation might be advantageous under conditions of a specific stress. We review the mechanisms by which replication initiated by transcription can lead to mutation. Second, we review recent findings that, although stress-induced mutation does not require exogenous DNA-damaging agents, it does require the presence of damaged bases in DNA. For starved E. coli, endogenous oxygen radicals cause these altered bases. We postulate that damaged bases stall the replisome, which, we suggest, is required for DNA-polymerase exchange, allowing the action of low-fidelity DNA polymerases that promote mutation." @default.
• W2782364694 created "2018-01-12" @default.
• W2782364694 creator A5005329427 @default.
• W2782364694 creator A5026001356 @default.
• W2782364694 creator A5065761747 @default.
• W2782364694 creator A5068732023 @default.
• W2782364694 date "2018-01-02" @default.
• W2782364694 modified "2023-10-10" @default.
• W2782364694 title "Oxygen and RNA in stress-induced mutation" @default.
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• W2782364694 doi "https://doi.org/10.1007/s00294-017-0801-9" @default.
• W2782364694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6028306" @default.
• W2782364694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29294174" @default.
• W2782364694 hasPublicationYear "2018" @default.
• W2782364694 type Work @default.

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