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• W2782404899 abstract "// Jianping Zhou 1, * , Jun Shi 1, * , Xingli Fu 2, * , Boneng Mao 3 , Weimin Wang 4 , Weiling Li 5 , Gang Li 5 and Sujun Zhou 1 1 Department of General Surgery, Yixing People’s Hospital The Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu, P.R China 2 Health Science Center, Jiangsu University, Zhenjiang 212000, Jiangsu, P.R China 3 Department of Gastroenterology, Yixing People’s Hospital The Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu, P.R China 4 Department of Oncology, Yixing People’s Hospital The Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu, P.R China 5 Yixing People’s Hospital The Affiliated Hospital of Jiangsu University, Yixing 214200, Jiangsu, P.R China * These authors contributed equally to this work Correspondence to: Sujun Zhou, email: staff030@sina.com Jianping Zhou, email: staff882@sina.com Keywords: gastric cancer; linc00441; RB1; DNMT1; proliferation Received: August 05, 2017      Accepted: November 03, 2017      Epub: January 03, 2018      Published: December 25, 2018 ABSTRACT Recent studies revealed that several Long noncoding RNAs (LncRNAs) are associated with progression of gastric cancer (GC), while the functional role and molecular mechanism of many GC-associated lncRNAs remain undetermined. The tumor suppressor-gene retinoblastoma gene (RB1) was decreased in several human cancers including gastric cancer (GC). In this study, we investigated whether Linc00441 was involved in the suppression of RB1. Our findings showed that the up-regulated Linc00441 was inversely correlated with RB1 expression in human GC tumor samples. The gain- and loss-of-function investigation revealed that Linc00441 could promote the proliferation of GC cells. Furthermore, RNA pull down and RIP assays demonstrated that Linc00441 could recruit DNMT1 to the RB1 promoter and suppressed RB1 expression in GC cells. In conclusion, our findings revealed that Linc00441 played crucial role in GC progression and suggested that Linc00441 was potentially an effective target for GC therapy in the future." @default.
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• W2782404899 date "2018-01-03" @default.
• W2782404899 modified "2023-09-26" @default.
• W2782404899 title "Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer" @default.
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• W2782404899 doi "https://doi.org/10.18632/oncotarget.23928" @default.
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