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• W2782425019 abstract "Retrogenes are formed when an mRNA is reverse-transcribed and reinserted into the genome in a location unrelated to the original locus. If this retrocopy inserts into a transcriptionally favourable locus and is able to carry out its original function, it can, in rare cases, lead to retrogene replacement. This involves the original, often multi-exonic, parental copy being lost whilst the newer single-exon retrogene copy 'replaces' the role of the ancestral parent gene. One example of this is amphioxus SYCP1, a gene that encodes a protein used in synaptonemal complex formation during meiosis and which offers the opportunity to examine how a retrogene evolves after the retrogene replacement event. SYCP1 genes exist as large multi-exonic genes in most animals. AmphiSYCP1, however, contains a single coding exon of ~ 3200 bp and has inserted next to the ParaHox cluster of amphioxus, whilst the multi-exonic ancestral parental copy has been lost. Here, we show that AmphiSYCP1 has not only replaced its parental copy, but also has evolved additional regulatory function by co-opting a bidirectional promoter from the nearby AmphiCHIC gene. AmphiSYCP1 has also evolved a de novo, multi-exonic 5'untranslated region that displays distinct regulatory states, in the form of two different isoforms, and has evolved novel expression patterns during amphioxus embryogenesis in addition to its ancestral role in meiosis. The absence of ParaHox-like expression of AmphiSYCP1, despite its proximity to the ParaHox cluster, also suggests that this gene is not influenced by any potential pan-cluster regulatory mechanisms, which are seemingly restricted to only the ParaHox genes themselves." @default.
• W2782425019 created "2018-01-12" @default.
• W2782425019 creator A5037757784 @default.
• W2782425019 creator A5086873853 @default.
• W2782425019 date "2018-01-01" @default.
• W2782425019 modified "2023-09-27" @default.
• W2782425019 title "Amphioxus SYCP1: a case of retrogene replacement and co-option of regulatory elements adjacent to the ParaHox cluster" @default.
• W2782425019 cites W1480582186 @default.
• W2782425019 cites W1503981888 @default.
• W2782425019 cites W1508097413 @default.
• W2782425019 cites W1508883137 @default.
• W2782425019 cites W1555019066 @default.
• W2782425019 cites W1903788602 @default.
• W2782425019 cites W1964497386 @default.
• W2782425019 cites W1968804024 @default.
• W2782425019 cites W1969692345 @default.
• W2782425019 cites W1971074826 @default.
• W2782425019 cites W1976032817 @default.
• W2782425019 cites W1981244256 @default.
• W2782425019 cites W1992876490 @default.
• W2782425019 cites W2000629769 @default.
• W2782425019 cites W2008658009 @default.
• W2782425019 cites W2012034410 @default.
• W2782425019 cites W2013881895 @default.
• W2782425019 cites W2017715780 @default.
• W2782425019 cites W2020583207 @default.
• W2782425019 cites W2021013626 @default.
• W2782425019 cites W2027693093 @default.
• W2782425019 cites W2028680701 @default.
• W2782425019 cites W2039994774 @default.
• W2782425019 cites W2044138972 @default.
• W2782425019 cites W2049263509 @default.
• W2782425019 cites W2055821541 @default.
• W2782425019 cites W2057472243 @default.
• W2782425019 cites W2060393964 @default.
• W2782425019 cites W2060798464 @default.
• W2782425019 cites W2061151633 @default.
• W2782425019 cites W2067331893 @default.
• W2782425019 cites W2074561828 @default.
• W2782425019 cites W2075435641 @default.
• W2782425019 cites W2075793022 @default.
• W2782425019 cites W2079141278 @default.
• W2782425019 cites W2084282362 @default.
• W2782425019 cites W2084404309 @default.
• W2782425019 cites W2087051730 @default.
• W2782425019 cites W2089161588 @default.
• W2782425019 cites W2090407309 @default.
• W2782425019 cites W2098235240 @default.
• W2782425019 cites W2098448352 @default.
• W2782425019 cites W2102042590 @default.
• W2782425019 cites W2103483161 @default.
• W2782425019 cites W2111211467 @default.
• W2782425019 cites W2111230820 @default.
• W2782425019 cites W2111481274 @default.
• W2782425019 cites W2113102645 @default.
• W2782425019 cites W2117179531 @default.
• W2782425019 cites W2120772351 @default.
• W2782425019 cites W2123318581 @default.
• W2782425019 cites W2126187754 @default.
• W2782425019 cites W2127322768 @default.
• W2782425019 cites W2129340339 @default.
• W2782425019 cites W2131101891 @default.
• W2782425019 cites W2132926880 @default.
• W2782425019 cites W2137015675 @default.
• W2782425019 cites W2140196050 @default.
• W2782425019 cites W2140428236 @default.
• W2782425019 cites W2144654387 @default.
• W2782425019 cites W2147125910 @default.
• W2782425019 cites W2147417521 @default.
• W2782425019 cites W2148821835 @default.
• W2782425019 cites W2152589171 @default.
• W2782425019 cites W2160838716 @default.
• W2782425019 cites W2162305104 @default.
• W2782425019 cites W2162504561 @default.
• W2782425019 cites W2163257295 @default.
• W2782425019 cites W2164454238 @default.
• W2782425019 cites W2165131746 @default.
• W2782425019 cites W2167535475 @default.
• W2782425019 cites W2168208516 @default.
• W2782425019 cites W2170258388 @default.
• W2782425019 cites W2171960324 @default.
• W2782425019 cites W2263954487 @default.
• W2782425019 cites W2284159252 @default.
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• W2782425019 cites W2415588997 @default.
• W2782425019 cites W316240425 @default.
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• W2782425019 cites W1564105277 @default.
• W2782425019 doi "https://doi.org/10.1007/s00427-017-0600-9" @default.
• W2782425019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5803294" @default.
• W2782425019 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29297095" @default.
• W2782425019 hasPublicationYear "2018" @default.
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• W2782425019 hasAuthorship W2782425019A5037757784 @default.
• W2782425019 hasAuthorship W2782425019A5086873853 @default.
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