Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782564462> ?p ?o ?g. }
- W2782564462 endingPage "773" @default.
- W2782564462 startingPage "760" @default.
- W2782564462 abstract "Peroxisome proliferator-activated receptors (PPARs) have been suggested as the master regulators of adipose tissue formation. However, their role in regulating brown fat functionality has not been resolved. To address this question, we generated mice with inducible brown fat-specific deletions of PPARα, β/δ, and γ, respectively. We found that both PPARα and β/δδ are dispensable for brown fat function. In contrast, we could show that ablation of PPARγ in vitro and in vivo led to a reduced thermogenic capacity accompanied by a loss of inducibility by β-adrenergic signaling, as well as a shift from oxidative fatty acid metabolism to glucose utilization. We identified glycerol kinase (Gyk) as a partial mediator of PPARγ function and could show that Gyk expression correlates with brown fat thermogenic capacity in human brown fat biopsies. Thus, Gyk might constitute the link between PPARγ-mediated regulation of brown fat function and activation by β-adrenergic signaling." @default.
- W2782564462 created "2018-01-26" @default.
- W2782564462 creator A5001846109 @default.
- W2782564462 creator A5002161503 @default.
- W2782564462 creator A5005810824 @default.
- W2782564462 creator A5007268149 @default.
- W2782564462 creator A5008020157 @default.
- W2782564462 creator A5016835561 @default.
- W2782564462 creator A5017891905 @default.
- W2782564462 creator A5020131648 @default.
- W2782564462 creator A5021616165 @default.
- W2782564462 creator A5023198863 @default.
- W2782564462 creator A5030309153 @default.
- W2782564462 creator A5037086101 @default.
- W2782564462 creator A5038203474 @default.
- W2782564462 creator A5050698758 @default.
- W2782564462 creator A5055753996 @default.
- W2782564462 creator A5061506021 @default.
- W2782564462 creator A5065855094 @default.
- W2782564462 creator A5070351080 @default.
- W2782564462 creator A5089920309 @default.
- W2782564462 date "2018-01-01" @default.
- W2782564462 modified "2023-10-02" @default.
- W2782564462 title "Peroxisome Proliferator Activated Receptor Gamma Controls Mature Brown Adipocyte Inducibility through Glycerol Kinase" @default.
- W2782564462 cites W100132181 @default.
- W2782564462 cites W130004309 @default.
- W2782564462 cites W1964895626 @default.
- W2782564462 cites W1965546738 @default.
- W2782564462 cites W1967133281 @default.
- W2782564462 cites W1968703258 @default.
- W2782564462 cites W1979026577 @default.
- W2782564462 cites W1979500386 @default.
- W2782564462 cites W1981478386 @default.
- W2782564462 cites W1982452808 @default.
- W2782564462 cites W1983006621 @default.
- W2782564462 cites W1983732035 @default.
- W2782564462 cites W1995398218 @default.
- W2782564462 cites W2004861205 @default.
- W2782564462 cites W2008204246 @default.
- W2782564462 cites W2013234028 @default.
- W2782564462 cites W2013900763 @default.
- W2782564462 cites W2022093304 @default.
- W2782564462 cites W2036620974 @default.
- W2782564462 cites W2055471277 @default.
- W2782564462 cites W2062600479 @default.
- W2782564462 cites W2064112171 @default.
- W2782564462 cites W2067532199 @default.
- W2782564462 cites W2073578030 @default.
- W2782564462 cites W2078107572 @default.
- W2782564462 cites W2081046229 @default.
- W2782564462 cites W2083602312 @default.
- W2782564462 cites W2096842458 @default.
- W2782564462 cites W2111517662 @default.
- W2782564462 cites W2112936536 @default.
- W2782564462 cites W2114821999 @default.
- W2782564462 cites W2118055379 @default.
- W2782564462 cites W2118733706 @default.
- W2782564462 cites W2131256997 @default.
- W2782564462 cites W2131820599 @default.
- W2782564462 cites W2135009079 @default.
- W2782564462 cites W2138973294 @default.
- W2782564462 cites W2145792347 @default.
- W2782564462 cites W2147130085 @default.
- W2782564462 cites W2156816825 @default.
- W2782564462 cites W2161687990 @default.
- W2782564462 cites W2162186867 @default.
- W2782564462 cites W2163047733 @default.
- W2782564462 cites W2164015929 @default.
- W2782564462 cites W2169726677 @default.
- W2782564462 cites W2297104511 @default.
- W2782564462 cites W2416954081 @default.
- W2782564462 cites W2470578474 @default.
- W2782564462 cites W2576212166 @default.
- W2782564462 doi "https://doi.org/10.1016/j.celrep.2017.12.067" @default.
- W2782564462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29346772" @default.
- W2782564462 hasPublicationYear "2018" @default.
- W2782564462 type Work @default.
- W2782564462 sameAs 2782564462 @default.
- W2782564462 citedByCount "76" @default.
- W2782564462 countsByYear W27825644622018 @default.
- W2782564462 countsByYear W27825644622019 @default.
- W2782564462 countsByYear W27825644622020 @default.
- W2782564462 countsByYear W27825644622021 @default.
- W2782564462 countsByYear W27825644622022 @default.
- W2782564462 countsByYear W27825644622023 @default.
- W2782564462 crossrefType "journal-article" @default.
- W2782564462 hasAuthorship W2782564462A5001846109 @default.
- W2782564462 hasAuthorship W2782564462A5002161503 @default.
- W2782564462 hasAuthorship W2782564462A5005810824 @default.
- W2782564462 hasAuthorship W2782564462A5007268149 @default.
- W2782564462 hasAuthorship W2782564462A5008020157 @default.
- W2782564462 hasAuthorship W2782564462A5016835561 @default.
- W2782564462 hasAuthorship W2782564462A5017891905 @default.
- W2782564462 hasAuthorship W2782564462A5020131648 @default.
- W2782564462 hasAuthorship W2782564462A5021616165 @default.
- W2782564462 hasAuthorship W2782564462A5023198863 @default.
- W2782564462 hasAuthorship W2782564462A5030309153 @default.
- W2782564462 hasAuthorship W2782564462A5037086101 @default.