FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782593800> ?p ?o ?g. }

• W2782593800 endingPage "576" @default.
• W2782593800 startingPage "569" @default.
• W2782593800 abstract "The neonatal brain has active energy metabolism, and glucose oxidation is the major energy source of brain tissue. Lactate is produced by astrocytes and released to neurons. In the central nervous system, lactate is transported between neurons and astrocytes via the astrocyte-neuron lactate shuttle. The aim of this study was to investigate the regulatory mechanisms of energy metabolism in neurons and astrocytes in the basal ganglia of a neonatal hypoxic-ischemic brain injury piglet model.A total of 35 healthy piglets (3-5 days of age; 1.0-1.5 kg) were assigned to a control group (n = 5) or a hypoxic-ischemic model group (n = 30). The hypoxic-ischemic model group was further divided into 6 groups according to the 1H-MR spectroscopy and PET/CT scan times after hypoxia-ischemia (0-2, 2-6, 6-12, 12-24, 24-48, and 48-72 hours; n = 5/group). 1H-MR spectroscopy data were processed with LCModel software. Maximum standard uptake values refer to the maximum standard uptake values for glucose (or FDG). The maximum standard uptake values of the basal ganglia-to-occipital cortex ratio were analyzed. The expression levels of glucose transporters and monocarboxylate transporters were detected by immunohistochemical analysis.Lactate levels decreased after an initial increase, with the maximal level occurring around 2-6 hours following hypoxia-ischemia. After hypoxia-ischemia, the maximum standard uptake values of the basal ganglia and basal ganglia/occipital cortex initially increased then decreased, with the maximum occurring at approximately 6-12 hours. The lactate and glucose uptake (basal ganglia/occipital cortex maximum standard uptake values) levels were positively correlated. The expression levels of glucose transporter-1 and glucose transporter-3 were positively correlated with the basal ganglia/occipital cortex. The expression levels of monocarboxylic acid transporter-2 and monocarboxylic acid transporter-4 were positively correlated with lactate content.The results indicate that lactate and glucose transporters have a synergistic effect on the energy metabolism of neurons and astrocytes following hypoxic-ischemic reperfusion brain injury." @default.
• W2782593800 created "2018-01-26" @default.
• W2782593800 creator A5013972195 @default.
• W2782593800 creator A5057216155 @default.
• W2782593800 date "2018-01-11" @default.
• W2782593800 modified "2023-10-12" @default.
• W2782593800 title "Expression Changes in Lactate and Glucose Metabolism and Associated Transporters in Basal Ganglia following Hypoxic-Ischemic Reperfusion Injury in Piglets" @default.
• W2782593800 cites W1730237872 @default.
• W2782593800 cites W1936012284 @default.
• W2782593800 cites W1966507725 @default.
• W2782593800 cites W1967660320 @default.
• W2782593800 cites W1976403273 @default.
• W2782593800 cites W1977980095 @default.
• W2782593800 cites W1989538987 @default.
• W2782593800 cites W1998976350 @default.
• W2782593800 cites W1999194953 @default.
• W2782593800 cites W2002568228 @default.
• W2782593800 cites W2012772303 @default.
• W2782593800 cites W2024625926 @default.
• W2782593800 cites W2025405502 @default.
• W2782593800 cites W2033508630 @default.
• W2782593800 cites W2035174766 @default.
• W2782593800 cites W2040233627 @default.
• W2782593800 cites W2051638758 @default.
• W2782593800 cites W2059457802 @default.
• W2782593800 cites W2062976574 @default.
• W2782593800 cites W2067215294 @default.
• W2782593800 cites W2067548955 @default.
• W2782593800 cites W2068504634 @default.
• W2782593800 cites W2073305247 @default.
• W2782593800 cites W2084245887 @default.
• W2782593800 cites W2084435168 @default.
• W2782593800 cites W2101488331 @default.
• W2782593800 cites W2107450931 @default.
• W2782593800 cites W2116050243 @default.
• W2782593800 cites W2118323661 @default.
• W2782593800 cites W2123716968 @default.
• W2782593800 cites W2125826114 @default.
• W2782593800 cites W2134471206 @default.
• W2782593800 cites W2145613240 @default.
• W2782593800 cites W2148611607 @default.
• W2782593800 cites W2153883114 @default.
• W2782593800 cites W2161480852 @default.
• W2782593800 cites W2195629230 @default.
• W2782593800 cites W2585694360 @default.
• W2782593800 cites W343602307 @default.
• W2782593800 doi "https://doi.org/10.3174/ajnr.a5505" @default.
• W2782593800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7655301" @default.
• W2782593800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29326137" @default.
• W2782593800 hasPublicationYear "2018" @default.
• W2782593800 type Work @default.
• W2782593800 sameAs 2782593800 @default.
• W2782593800 citedByCount "14" @default.
• W2782593800 countsByYear W27825938002020 @default.
• W2782593800 countsByYear W27825938002021 @default.
• W2782593800 countsByYear W27825938002022 @default.
• W2782593800 countsByYear W27825938002023 @default.
• W2782593800 crossrefType "journal-article" @default.
• W2782593800 hasAuthorship W2782593800A5013972195 @default.
• W2782593800 hasAuthorship W2782593800A5057216155 @default.
• W2782593800 hasBestOaLocation W27825938001 @default.
• W2782593800 hasConcept C104317684 @default.
• W2782593800 hasConcept C126322002 @default.
• W2782593800 hasConcept C134018914 @default.
• W2782593800 hasConcept C149011108 @default.
• W2782593800 hasConcept C161573976 @default.
• W2782593800 hasConcept C178790620 @default.
• W2782593800 hasConcept C185592680 @default.
• W2782593800 hasConcept C2777542381 @default.
• W2782593800 hasConcept C2778024521 @default.
• W2782593800 hasConcept C2778187257 @default.
• W2782593800 hasConcept C2779306644 @default.
• W2782593800 hasConcept C2781217356 @default.
• W2782593800 hasConcept C42219234 @default.
• W2782593800 hasConcept C529278444 @default.
• W2782593800 hasConcept C540031477 @default.
• W2782593800 hasConcept C541997718 @default.
• W2782593800 hasConcept C55493867 @default.
• W2782593800 hasConcept C62231903 @default.
• W2782593800 hasConcept C71924100 @default.
• W2782593800 hasConcept C7836513 @default.
• W2782593800 hasConcept C86803240 @default.
• W2782593800 hasConceptScore W2782593800C104317684 @default.
• W2782593800 hasConceptScore W2782593800C126322002 @default.
• W2782593800 hasConceptScore W2782593800C134018914 @default.
• W2782593800 hasConceptScore W2782593800C149011108 @default.
• W2782593800 hasConceptScore W2782593800C161573976 @default.
• W2782593800 hasConceptScore W2782593800C178790620 @default.
• W2782593800 hasConceptScore W2782593800C185592680 @default.
• W2782593800 hasConceptScore W2782593800C2777542381 @default.
• W2782593800 hasConceptScore W2782593800C2778024521 @default.
• W2782593800 hasConceptScore W2782593800C2778187257 @default.
• W2782593800 hasConceptScore W2782593800C2779306644 @default.
• W2782593800 hasConceptScore W2782593800C2781217356 @default.
• W2782593800 hasConceptScore W2782593800C42219234 @default.
• W2782593800 hasConceptScore W2782593800C529278444 @default.
• W2782593800 hasConceptScore W2782593800C540031477 @default.
• W2782593800 hasConceptScore W2782593800C541997718 @default.

• next