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- W2782696110 endingPage "26" @default.
- W2782696110 startingPage "14" @default.
- W2782696110 abstract "Despite the success of antiretroviral therapy (ART), there is currently no HIV cure and treatment is life long. HIV persists during ART due to long-lived and proliferating latently infected CD4+ T cells. One strategy to eliminate latency is to activate virus production using latency reversing agents (LRAs) with the goal of triggering cell death through virus-induced cytolysis or immune-mediated clearance. However, multiple studies have demonstrated that activation of viral transcription alone is insufficient to induce cell death and some LRAs may counteract cell death by promoting cell survival. Here, we review new approaches to induce death of latently infected cells through apoptosis and inhibition of pathways critical for cell survival, which are often hijacked by HIV proteins. Given advances in the commercial development of compounds that induce apoptosis in cancer chemotherapy, these agents could move rapidly into clinical trials, either alone or in combination with LRAs, to eliminate latent HIV infection." @default.
- W2782696110 created "2018-01-26" @default.
- W2782696110 creator A5041557054 @default.
- W2782696110 creator A5058694353 @default.
- W2782696110 creator A5062645957 @default.
- W2782696110 date "2018-01-01" @default.
- W2782696110 modified "2023-10-10" @default.
- W2782696110 title "Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV" @default.
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