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- W2782794977 abstract "Glipizide is one of the most widely used oral hypoglycemic agents in the control of diabetes mellitus. It belongs to the class sulphonyl urea and is available as an immediate release tablet and controlled release tablet for once a day dosing. The innovator controlled release product of glipizide is glucotrol XL which is based on the osmotic drug delivery system is difficult to formulate and expensive to scale up since it involves investment in putting up a laser drill for drilling the hole required for the fluid to permeate into the system.The current work is aimed at formulating a drug delivery system which will deliver the drug over 24 hours at the same rate of delivery as that of glucotrol XL but using the micro porous membrane drug delivery system and the multi unit particulate platform (MUPS).Objectives: To standardize a procedure for loading drug on to non peril pellets. To determine the optimum level of ethyl cellulose needed to coat the pellets in order to get nearly zero order drug release from the pellets. To study the role of two different types of pore formers in modulating drug release to match to the target product profile. This study was conducted using full factorial design of experiments. Glipizide controlled release formulation is one of the most widely prescribed oral hypoglycemic agent. The innovator for product Glucotrol XL is based on the osmotic drug delivery platform and has a very peculiar dissolution profile. There is a two hours lag time in which less than 5% of the drug is targeted to be release followed by a zero order drug release at a rate of 3 to 7 % per hour. Ordinary matrix diffusion systems are very difficult to formulate for such type of specialized release rate requirements since these systems are based mainly on diffusion across swollen matrix.The MUPS technology provides a unique platform to modulate the drug release to match the target release profile since it is possible to coat the pellets in a controlled manner with an polymer and a pore former.In the current work, Glipizide controlled release product was developed using the MUPS platform, and ethyl cellulose as the membrane. The role of two water soluble polymers in modulating the drug release was evaluated using full factorial design of experiments.The process followed for fabricating the dosage form was by first loading the drug on to pellets by using the fluid bed processor attached with bottom spray assembly." @default.
- W2782794977 created "2018-01-26" @default.
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- W2782794977 date "2014-04-01" @default.
- W2782794977 modified "2023-09-27" @default.
- W2782794977 title "Multi Unit Particulate System for Controlled Release of Glipizide" @default.
- W2782794977 hasPublicationYear "2014" @default.
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