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• W2782840355 abstract "Dopamine is a neurotransmitter implicated in several brain functions, including vision. In the present study, we investigated the impacts of the lack of D2 dopamine receptors on the structure and function of the primary visual cortex (V1) of D2-KO mice using optical imaging of intrinsic signals. Retinotopic maps were generated in order to measure anatomo-functional parameters such as V1 shape, cortical magnification factor, scatter, and ocular dominance. Contrast sensitivity and spatial frequency selectivity (SF) functions were computed from responses to drifting gratings. When compared to control mice, none of the parameters of the retinotopic maps were affected by D2 receptor loss of function. While the contrast sensitivity function of D2-KO mice did not differ from their wild-type counterparts, SF selectivity function was significantly affected as the optimal SF and the high cut-off frequency (p<0.01) were higher in D2-KO than in WT mice. These findings show that the lack of function of D2 dopamine receptors had no influence on cortical structure whereas it had a significant impact on the spatial frequency selectivity and high cut-off. Taken together, our results suggest that D2 receptors play a specific role on the processing of spatial features in early visual cortex while they do not seem to participate in its development." @default.
• W2782840355 created "2018-01-26" @default.
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• W2782840355 date "2018-01-15" @default.
• W2782840355 modified "2023-10-01" @default.
• W2782840355 title "Spatial Frequency Selectivity Is Impaired in Dopamine D2 Receptor Knockout Mice" @default.
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• W2782840355 doi "https://doi.org/10.3389/fnint.2017.00041" @default.
• W2782840355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5775240" @default.
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