Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782882012> ?p ?o ?g. }
- W2782882012 endingPage "1061" @default.
- W2782882012 startingPage "1047" @default.
- W2782882012 abstract "Riluzole is a drug, used to slow the course of amyotrophic lateral sclerosis. Due to its unique structure and functionalities, it is able to form both salts and cocrystals. This is a BCS class II drug with poor solubility and causes hepatotoxicity which limits its application. The present study aims toward development of novel solid forms of riluzole to address the said limitations. Apart from this, an attempt has been made to develop a prediction model using software tools to identify the appropriate synthons for formation of cocrystals. It was observed that out of 33 coformers selected, prediction results were in agreement with the experimental outcome for 25 coformers, which demonstrated the potential of the model developed. Seven new solid forms of riluzole, five cocrystals with ferulic acid, syringic acid, vanillic acid, cinnamic acid, and proline, and two salts with 2,4 dihydroxybenzoic acid and fumaric acid were successfully developed. All the solid forms were characterized by DSC, powder XRD, FTIR..." @default.
- W2782882012 created "2018-01-26" @default.
- W2782882012 creator A5030188730 @default.
- W2782882012 creator A5056508964 @default.
- W2782882012 creator A5056902765 @default.
- W2782882012 creator A5076164666 @default.
- W2782882012 creator A5087360391 @default.
- W2782882012 creator A5091727141 @default.
- W2782882012 date "2018-01-26" @default.
- W2782882012 modified "2023-09-24" @default.
- W2782882012 title "Hepatoprotective Cocrystals and Salts of Riluzole: Prediction, Synthesis, Solid State Characterization, and Evaluation" @default.
- W2782882012 cites W1965028792 @default.
- W2782882012 cites W1969360633 @default.
- W2782882012 cites W1976544366 @default.
- W2782882012 cites W1981321640 @default.
- W2782882012 cites W1985196300 @default.
- W2782882012 cites W1986341493 @default.
- W2782882012 cites W1995634417 @default.
- W2782882012 cites W2006719904 @default.
- W2782882012 cites W2006957749 @default.
- W2782882012 cites W2007068681 @default.
- W2782882012 cites W2011134011 @default.
- W2782882012 cites W2014263842 @default.
- W2782882012 cites W2025563275 @default.
- W2782882012 cites W2027266498 @default.
- W2782882012 cites W2049958331 @default.
- W2782882012 cites W2056717822 @default.
- W2782882012 cites W2068315260 @default.
- W2782882012 cites W2074168967 @default.
- W2782882012 cites W2076406171 @default.
- W2782882012 cites W2086973672 @default.
- W2782882012 cites W2094467572 @default.
- W2782882012 cites W2097481983 @default.
- W2782882012 cites W2101536662 @default.
- W2782882012 cites W2130792254 @default.
- W2782882012 cites W2135824076 @default.
- W2782882012 cites W2156398854 @default.
- W2782882012 cites W2302505094 @default.
- W2782882012 cites W2318118297 @default.
- W2782882012 cites W2319993349 @default.
- W2782882012 cites W2320780208 @default.
- W2782882012 cites W2330488356 @default.
- W2782882012 cites W2410157843 @default.
- W2782882012 cites W2512752931 @default.
- W2782882012 cites W2593523402 @default.
- W2782882012 cites W2952528349 @default.
- W2782882012 doi "https://doi.org/10.1021/acs.cgd.7b01514" @default.
- W2782882012 hasPublicationYear "2018" @default.
- W2782882012 type Work @default.
- W2782882012 sameAs 2782882012 @default.
- W2782882012 citedByCount "34" @default.
- W2782882012 countsByYear W27828820122018 @default.
- W2782882012 countsByYear W27828820122019 @default.
- W2782882012 countsByYear W27828820122020 @default.
- W2782882012 countsByYear W27828820122021 @default.
- W2782882012 countsByYear W27828820122022 @default.
- W2782882012 countsByYear W27828820122023 @default.
- W2782882012 crossrefType "journal-article" @default.
- W2782882012 hasAuthorship W2782882012A5030188730 @default.
- W2782882012 hasAuthorship W2782882012A5056508964 @default.
- W2782882012 hasAuthorship W2782882012A5056902765 @default.
- W2782882012 hasAuthorship W2782882012A5076164666 @default.
- W2782882012 hasAuthorship W2782882012A5087360391 @default.
- W2782882012 hasAuthorship W2782882012A5091727141 @default.
- W2782882012 hasConcept C100687433 @default.
- W2782882012 hasConcept C107814960 @default.
- W2782882012 hasConcept C112887158 @default.
- W2782882012 hasConcept C147789679 @default.
- W2782882012 hasConcept C171250308 @default.
- W2782882012 hasConcept C178790620 @default.
- W2782882012 hasConcept C185592680 @default.
- W2782882012 hasConcept C192562407 @default.
- W2782882012 hasConcept C21951064 @default.
- W2782882012 hasConcept C2780841128 @default.
- W2782882012 hasConcept C32909587 @default.
- W2782882012 hasConceptScore W2782882012C100687433 @default.
- W2782882012 hasConceptScore W2782882012C107814960 @default.
- W2782882012 hasConceptScore W2782882012C112887158 @default.
- W2782882012 hasConceptScore W2782882012C147789679 @default.
- W2782882012 hasConceptScore W2782882012C171250308 @default.
- W2782882012 hasConceptScore W2782882012C178790620 @default.
- W2782882012 hasConceptScore W2782882012C185592680 @default.
- W2782882012 hasConceptScore W2782882012C192562407 @default.
- W2782882012 hasConceptScore W2782882012C21951064 @default.
- W2782882012 hasConceptScore W2782882012C2780841128 @default.
- W2782882012 hasConceptScore W2782882012C32909587 @default.
- W2782882012 hasFunder F4320321025 @default.
- W2782882012 hasIssue "2" @default.
- W2782882012 hasLocation W27828820121 @default.
- W2782882012 hasOpenAccess W2782882012 @default.
- W2782882012 hasPrimaryLocation W27828820121 @default.
- W2782882012 hasRelatedWork W1982104575 @default.
- W2782882012 hasRelatedWork W2090850713 @default.
- W2782882012 hasRelatedWork W2098961347 @default.
- W2782882012 hasRelatedWork W2331592696 @default.
- W2782882012 hasRelatedWork W2395151676 @default.
- W2782882012 hasRelatedWork W2935366852 @default.
- W2782882012 hasRelatedWork W2952532116 @default.