FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2782900632> ?p ?o ?g. }

• W2782900632 endingPage "189" @default.
• W2782900632 startingPage "183" @default.
• W2782900632 abstract "BACKGROUND:Gremlin has been reported to be up-regulated in glomerular mesangial cells in diabetic nephropathy (DN). However, the regulation of gremlin in podocytes is still rarely reported. This study aimed to investigate the underlying mechanisms by which gremlin mediates the pathogenesis of DN via transforming growth factor-β (TGF-β) signaling pathways. MATERIAL AND METHODS:Lentiviral and RNAi transfection were performed to increase and decrease gremlin expression in high-glucose conditions. Expression at the mRNA and protein level was detected by RT-qPCR and Western blotting. RESULTS:The expression of gremlin was significantly higher in high-glucose (HG, 30mM) than normal-glucose (NG, 5.5 mM) conditions. The gremlin overexpression significantly suppressed the expression of nephrin and synaptopodin. The phosphorylation of canonical TGF-b signaling pathway components, including Smad2/3 and MKK, was increased in the gremlin-overexpressing group. In addition, the expression levels of Bax and cleaved caspase-3 were also higher in the gremlin-overexpressing group. TGF-β pathway inhibitor (SB505124) significantly inhibited TGF-β pathway activity and enhanced the expression of nephrin and synaptopodin. CONCLUSIONS:These results indicate that gremlin can aggravate podocyte lesions through the TGF-β signaling pathway, providing a novel therapeutic target for DN." @default.
• W2782900632 created "2018-01-26" @default.
• W2782900632 creator A5012788495 @default.
• W2782900632 creator A5055905669 @default.
• W2782900632 creator A5062819262 @default.
• W2782900632 creator A5077880623 @default.
• W2782900632 date "2018-01-09" @default.
• W2782900632 modified "2023-09-29" @default.
• W2782900632 title "Gremlin Regulates Podocyte Apoptosis via Transforming Growth Factor-β (TGF-β) Pathway in Diabetic Nephropathy" @default.
• W2782900632 cites W1148434115 @default.
• W2782900632 cites W1540786657 @default.
• W2782900632 cites W1595346840 @default.
• W2782900632 cites W1788736447 @default.
• W2782900632 cites W1981914774 @default.
• W2782900632 cites W1985804361 @default.
• W2782900632 cites W1985900967 @default.
• W2782900632 cites W1988107261 @default.
• W2782900632 cites W1989254729 @default.
• W2782900632 cites W1990811421 @default.
• W2782900632 cites W1992829978 @default.
• W2782900632 cites W1995607119 @default.
• W2782900632 cites W2019975221 @default.
• W2782900632 cites W2030107745 @default.
• W2782900632 cites W2060089472 @default.
• W2782900632 cites W2073255047 @default.
• W2782900632 cites W2076087769 @default.
• W2782900632 cites W2085574022 @default.
• W2782900632 cites W2108918534 @default.
• W2782900632 cites W2119033248 @default.
• W2782900632 cites W2122219276 @default.
• W2782900632 cites W2138256890 @default.
• W2782900632 cites W2143772121 @default.
• W2782900632 cites W2162196137 @default.
• W2782900632 cites W2170271198 @default.
• W2782900632 cites W2298880073 @default.
• W2782900632 doi "https://doi.org/10.12659/msm.905758" @default.
• W2782900632 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5771160" @default.
• W2782900632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315280" @default.
• W2782900632 hasPublicationYear "2018" @default.
• W2782900632 type Work @default.
• W2782900632 sameAs 2782900632 @default.
• W2782900632 citedByCount "18" @default.
• W2782900632 countsByYear W27829006322018 @default.
• W2782900632 countsByYear W27829006322019 @default.
• W2782900632 countsByYear W27829006322020 @default.
• W2782900632 countsByYear W27829006322021 @default.
• W2782900632 countsByYear W27829006322022 @default.
• W2782900632 crossrefType "journal-article" @default.
• W2782900632 hasAuthorship W2782900632A5012788495 @default.
• W2782900632 hasAuthorship W2782900632A5055905669 @default.
• W2782900632 hasAuthorship W2782900632A5062819262 @default.
• W2782900632 hasAuthorship W2782900632A5077880623 @default.
• W2782900632 hasBestOaLocation W27829006322 @default.
• W2782900632 hasConcept C118131993 @default.
• W2782900632 hasConcept C126322002 @default.
• W2782900632 hasConcept C134018914 @default.
• W2782900632 hasConcept C2777146197 @default.
• W2782900632 hasConcept C2779561371 @default.
• W2782900632 hasConcept C2779922275 @default.
• W2782900632 hasConcept C2780091579 @default.
• W2782900632 hasConcept C2780819817 @default.
• W2782900632 hasConcept C2910727860 @default.
• W2782900632 hasConcept C502942594 @default.
• W2782900632 hasConcept C54009773 @default.
• W2782900632 hasConcept C54355233 @default.
• W2782900632 hasConcept C555293320 @default.
• W2782900632 hasConcept C62478195 @default.
• W2782900632 hasConcept C71924100 @default.
• W2782900632 hasConcept C81885089 @default.
• W2782900632 hasConcept C86803240 @default.
• W2782900632 hasConcept C95444343 @default.
• W2782900632 hasConceptScore W2782900632C118131993 @default.
• W2782900632 hasConceptScore W2782900632C126322002 @default.
• W2782900632 hasConceptScore W2782900632C134018914 @default.
• W2782900632 hasConceptScore W2782900632C2777146197 @default.
• W2782900632 hasConceptScore W2782900632C2779561371 @default.
• W2782900632 hasConceptScore W2782900632C2779922275 @default.
• W2782900632 hasConceptScore W2782900632C2780091579 @default.
• W2782900632 hasConceptScore W2782900632C2780819817 @default.
• W2782900632 hasConceptScore W2782900632C2910727860 @default.
• W2782900632 hasConceptScore W2782900632C502942594 @default.
• W2782900632 hasConceptScore W2782900632C54009773 @default.
• W2782900632 hasConceptScore W2782900632C54355233 @default.
• W2782900632 hasConceptScore W2782900632C555293320 @default.
• W2782900632 hasConceptScore W2782900632C62478195 @default.
• W2782900632 hasConceptScore W2782900632C71924100 @default.
• W2782900632 hasConceptScore W2782900632C81885089 @default.
• W2782900632 hasConceptScore W2782900632C86803240 @default.
• W2782900632 hasConceptScore W2782900632C95444343 @default.
• W2782900632 hasLocation W27829006321 @default.
• W2782900632 hasLocation W27829006322 @default.
• W2782900632 hasLocation W27829006323 @default.
• W2782900632 hasLocation W27829006324 @default.
• W2782900632 hasOpenAccess W2782900632 @default.
• W2782900632 hasPrimaryLocation W27829006321 @default.
• W2782900632 hasRelatedWork W1997765647 @default.
• W2782900632 hasRelatedWork W2012648676 @default.
• W2782900632 hasRelatedWork W2101094231 @default.

• next