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- W2782912453 endingPage "608" @default.
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- W2782912453 abstract "Nucleoside diphosphate kinases (NDPKs/NDK/NME) are a multifunctional class of proteins conserved throughout evolution. Whilst many of the functions of NDPKs have been identified as intracellular, extracellular eukaryotic and prokaryotic NDPK proteins are also detected in multiple systems and have been implicated in both normal physiology and disease. This review provides an overview of where the field stands on our developing understanding of how NDPK proteins get out of cells, the physiological role of extracellular NDPKs, and how extracellular NDPKs may signal to cells. We will also discuss some of the unanswered questions, the ‘known-unknowns' that particularly warrant further investigation." @default.
- W2782912453 created "2018-01-26" @default.
- W2782912453 creator A5015137207 @default.
- W2782912453 creator A5065682964 @default.
- W2782912453 date "2018-05-01" @default.
- W2782912453 modified "2023-09-29" @default.
- W2782912453 title "The ‘known-knowns', and ‘known-unknowns' of extracellular Nm23-H1/NDPK proteins" @default.
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- W2782912453 doi "https://doi.org/10.1038/s41374-017-0012-5" @default.
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