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• W2782916425 endingPage "112" @default.
• W2782916425 startingPage "94" @default.
• W2782916425 abstract "Growth hormone (GH), prolactin (PRL), prolactin 2 (PRL2) and somatolactin (SL) belong to the same hormone family and have a wide repertoire of effects including development, osmoregulation, metabolism and stimulation of growth. Both the hormone and the receptor family have been proposed to have expanded by gene duplications in early vertebrate evolution. A key question is how hormone-receptor preferences have arisen among the duplicates. The first step to address this is to determine the time window for these duplications. Specifically, we aimed to see if duplications resulted from the two basal vertebrate tetraploidizations (1R and 2R). GH family genes from a broad range of vertebrate genomes were investigated using a combination of sequence-based phylogenetic analyses and comparisons of synteny. We conclude that the PRL and PRL2 genes arose from a common ancestor in 1R/2R, as shown by neighboring gene families. No other gene duplicates were preserved from these tetraploidization events. The ancestral genes that would give rise to GH and PRL/PRL2 arose from an earlier duplication; most likely a local gene duplication as they are syntenic in several species. Likewise, some evidence suggests that SL arose from a local duplication of an ancestral GH/SL gene in the same time window, explaining the lack of similarity in chromosomal neighbors to GH, PRL or PRL2. Thus, the basic triplet of ancestral GH, PRL/PRL2 and SL genes appear to be unexpectedly ancient. Following 1R/2R, only SL was duplicated in the teleost-specific tetraploidization 3R, resulting in SLa and SLb. These time windows contrast with our recent report that the corresponding receptor genes GHR and PRLR arose through a local duplication in jawed vertebrates and that both receptor genes duplicated further in 3R, which reveals a surprising asynchrony in hormone and receptor gene duplications." @default.
• W2782916425 created "2018-01-26" @default.
• W2782916425 creator A5061245649 @default.
• W2782916425 creator A5090302589 @default.
• W2782916425 date "2018-08-01" @default.
• W2782916425 modified "2023-09-27" @default.
• W2782916425 title "Evolution of the growth hormone, prolactin, prolactin 2 and somatolactin family" @default.
• W2782916425 cites W1497965471 @default.
• W2782916425 cites W1646616821 @default.
• W2782916425 cites W1847769736 @default.
• W2782916425 cites W1910171659 @default.
• W2782916425 cites W1963630241 @default.
• W2782916425 cites W1970092595 @default.
• W2782916425 cites W1972895511 @default.
• W2782916425 cites W1980413383 @default.
• W2782916425 cites W1982576538 @default.
• W2782916425 cites W1982637424 @default.
• W2782916425 cites W1983102293 @default.
• W2782916425 cites W1993616323 @default.
• W2782916425 cites W1994286487 @default.
• W2782916425 cites W1994377311 @default.
• W2782916425 cites W2001332800 @default.
• W2782916425 cites W2005228725 @default.
• W2782916425 cites W2008208329 @default.
• W2782916425 cites W2008771493 @default.
• W2782916425 cites W2009336912 @default.
• W2782916425 cites W2009646489 @default.
• W2782916425 cites W2013884373 @default.
• W2782916425 cites W2017593042 @default.
• W2782916425 cites W2017670830 @default.
• W2782916425 cites W2022459631 @default.
• W2782916425 cites W2030601224 @default.
• W2782916425 cites W2031536564 @default.
• W2782916425 cites W2032840748 @default.
• W2782916425 cites W2034408565 @default.
• W2782916425 cites W2034499270 @default.
• W2782916425 cites W2034654722 @default.
• W2782916425 cites W2036523102 @default.
• W2782916425 cites W2036683980 @default.
• W2782916425 cites W2038267178 @default.
• W2782916425 cites W2045556058 @default.
• W2782916425 cites W2047405437 @default.
• W2782916425 cites W2050078259 @default.
• W2782916425 cites W2050720051 @default.
• W2782916425 cites W2050874831 @default.
• W2782916425 cites W2054338078 @default.
• W2782916425 cites W2055043387 @default.
• W2782916425 cites W2055678311 @default.
• W2782916425 cites W2056564376 @default.
• W2782916425 cites W2056907676 @default.
• W2782916425 cites W2057652201 @default.
• W2782916425 cites W2058339468 @default.
• W2782916425 cites W2061041720 @default.
• W2782916425 cites W2062874910 @default.
• W2782916425 cites W2063512844 @default.
• W2782916425 cites W2063807032 @default.
• W2782916425 cites W2064912476 @default.
• W2782916425 cites W2065636600 @default.
• W2782916425 cites W2068108747 @default.
• W2782916425 cites W2070683395 @default.
• W2782916425 cites W2073550716 @default.
• W2782916425 cites W2074282399 @default.
• W2782916425 cites W2077339327 @default.
• W2782916425 cites W2079382095 @default.
• W2782916425 cites W2081453228 @default.
• W2782916425 cites W2081778808 @default.
• W2782916425 cites W2081842163 @default.
• W2782916425 cites W2082393218 @default.
• W2782916425 cites W2082568684 @default.
• W2782916425 cites W2082966090 @default.
• W2782916425 cites W2084486673 @default.
• W2782916425 cites W2087585765 @default.
• W2782916425 cites W2090183008 @default.
• W2782916425 cites W2093178517 @default.
• W2782916425 cites W2094114124 @default.
• W2782916425 cites W2096544606 @default.
• W2782916425 cites W2098448352 @default.
• W2782916425 cites W2098522644 @default.
• W2782916425 cites W2100424570 @default.
• W2782916425 cites W2104998102 @default.
• W2782916425 cites W2106355394 @default.
• W2782916425 cites W2107036065 @default.
• W2782916425 cites W2109106935 @default.
• W2782916425 cites W2111258331 @default.
• W2782916425 cites W2111647009 @default.
• W2782916425 cites W2114899638 @default.
• W2782916425 cites W2117832333 @default.
• W2782916425 cites W2126525419 @default.
• W2782916425 cites W2128265196 @default.
• W2782916425 cites W2128440410 @default.
• W2782916425 cites W2131871062 @default.
• W2782916425 cites W2132926880 @default.
• W2782916425 cites W2135531862 @default.
• W2782916425 cites W2135621733 @default.
• W2782916425 cites W2135740919 @default.
• W2782916425 cites W2136126520 @default.
• W2782916425 cites W2141431840 @default.
• W2782916425 cites W2145306886 @default.

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