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- W2782930357 abstract "INTRODUCTION:Hypothyroidism results from inadequate production of thyroid hormone,And is classified as clinical or subclinical, depending on the degree of clinicalSeverity and the extent of abnormalities in thyroid indices. In overt or clinicalHypothyroidism, thyroid hormone levels are low, and TSH is elevated.Subclinical hypothyroidism describes a condition in which T3 and T4 levels areNormal but TSH is elevated, or the TSH response to TRH infusion isExaggerated.The prevalence of clinical hypothyroidism is approximately 2% inWomen and less than 0.1% in men. Subclinical hypothyroidism alsoPredominates in women, occuring in approximately 7.5% of women and 3% inMen. Elderly women are estimated to have upto 16% of subclinicalHypothyroidism.Hashimoto's thyroiditis is the most common cause of clinicalHypothyroidism. Other causes are idiopathic atrophy of thyroid gland, iodineDeficiency, hypopituitarism, iatrogenic hypothyroidism. Symptoms are coldIntolerance, constipation, muscle cramps, menstrual disturbances (amenorrhoeaOr menorrhagia), weight gain, dyspnoea, husky voice, slowed dtrs,Bradycardia, cardiomegaly, dizziness, syncope, poor appetite, normocytic,Normochromic anemia.Psychiatric symptoms most commonly related to thyroid deficiencyInclude forgetfulness, fatigue, mental slowness, inattention and emotionalLability. The predominant affective disorder experienced is depression.Delusions and hallucinations may occur as the disease progresses. NoCorrelation, however, appears to exist between the degree of thyroidDysfunction and psychiatric symptoms that subsequently develop.Depression has been the major affective illness described in hypothyroidPatients. Approximately 40% of clinically hypothyroid patients have significantSigns and symptoms of depression. Although the relationship betweenSubclinical hypothyroidism and depression remains controversial, a moreFirmly established relationship exists between treatment resistant depressionAnd subclinical hypothyroidism.A central serotonergic deficiency, brain catecholamine deficiency,Inhibition of type-II 5-deiodinase enzyme, a state of relative cerebralHypothyroidism are the proposed hypotheses linking depressive symptoms inHypothyroidism.Cognitive dysfunction also may be a result of hypothyroidism, mostCommonly, psychomotor slowing, deficits in memory, visuoperceptual skillsAnd constructional dexterity. Cognitive decline secondary to thyroid deficiency,May represent dementia, which is reversible with thyroxine replacementTherapy.Psychosis typically emerges after the onset of physical symptoms, oftenAfter a period of years or months. Manifestations include delusions (oftenParanoid), visual or auditary hallucinations, perseveration, loosening ofAssociation. These psychotic symptoms can occur without delirium orDementia.The prevalence of major depression among hypothyroid patients is 33%-43%, Anxiety disorder is 20%-33%, cognitive impairement 29% andPsychosis/delirium is 5%.This study focusses on psychiatric morbidity among hypothyroidPatients. Since correction of thyroid deficiency may reverse psychiatricManifestations, drug-naive hypothyroid patients were included. Only adultPopulation were included in this study." @default.
- W2782930357 created "2018-01-26" @default.
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- W2782930357 date "2008-03-01" @default.
- W2782930357 modified "2023-09-27" @default.
- W2782930357 title "Psychiatric Morbidity in Drug-Naive Hypothyroid Patients." @default.
- W2782930357 hasPublicationYear "2008" @default.
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