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- W2783000324 abstract "Glioblastoma (GBM) is considered one of the most malignant, genetically heterogeneous, and therapy-resistant solid tumor. Therapeutic options are limited in GBM and involve surgical resection followed by chemotherapy and/or radiotherapy. Adjuvant therapies, including antiangiogenic treatments (AATs) targeting the VEGF–VEGFR pathway, have witnessed enhanced infiltration of bone marrow-derived myeloid cells, causing therapy resistance and tumor relapse in clinics and in preclinical models of GBM. This review article is focused on gathering previous clinical and preclinical reports featuring major challenges and lessons in GBM. Potential combination therapies targeting the tumor microenvironment (TME) to overcome the myeloid cell-mediated resistance problem in GBM are discussed. Future directions are focused on the use of TME-directed therapies in combination with standard therapy in clinical trials, and the exploration of novel therapies and GBM models for preclinical studies. We believe this review will guide the future of GBM research and therapy." @default.
- W2783000324 created "2018-01-26" @default.
- W2783000324 creator A5000876055 @default.
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- W2783000324 creator A5066270902 @default.
- W2783000324 creator A5073124516 @default.
- W2783000324 creator A5084045313 @default.
- W2783000324 date "2017-12-16" @default.
- W2783000324 modified "2023-10-16" @default.
- W2783000324 title "Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma" @default.
- W2783000324 cites W132217434 @default.
- W2783000324 cites W1501247525 @default.
- W2783000324 cites W1511075757 @default.
- W2783000324 cites W1519299662 @default.
- W2783000324 cites W1538700966 @default.
- W2783000324 cites W1541410140 @default.
- W2783000324 cites W162807232 @default.
- W2783000324 cites W163220513 @default.
- W2783000324 cites W1643834408 @default.
- W2783000324 cites W1874566015 @default.
- W2783000324 cites W1902059139 @default.
- W2783000324 cites W1917703525 @default.
- W2783000324 cites W1946170785 @default.
- W2783000324 cites W1960833393 @default.
- W2783000324 cites W1964432330 @default.
- W2783000324 cites W1965696083 @default.
- W2783000324 cites W1967060514 @default.
- W2783000324 cites W1971031493 @default.
- W2783000324 cites W1976659174 @default.
- W2783000324 cites W1976748435 @default.
- W2783000324 cites W1977424137 @default.
- W2783000324 cites W1978139448 @default.
- W2783000324 cites W1980460601 @default.
- W2783000324 cites W1980485314 @default.
- W2783000324 cites W1982236564 @default.
- W2783000324 cites W1982912692 @default.
- W2783000324 cites W1986758971 @default.
- W2783000324 cites W1987322383 @default.
- W2783000324 cites W1992112921 @default.
- W2783000324 cites W1993442154 @default.
- W2783000324 cites W1994380010 @default.
- W2783000324 cites W1995232616 @default.
- W2783000324 cites W1997944395 @default.
- W2783000324 cites W1999873680 @default.
- W2783000324 cites W2002727873 @default.
- W2783000324 cites W2007197271 @default.
- W2783000324 cites W2008621673 @default.
- W2783000324 cites W2010363079 @default.
- W2783000324 cites W2016054769 @default.
- W2783000324 cites W2024893745 @default.
- W2783000324 cites W2025770283 @default.
- W2783000324 cites W2028814725 @default.
- W2783000324 cites W2029470215 @default.
- W2783000324 cites W2030537668 @default.
- W2783000324 cites W2032995169 @default.
- W2783000324 cites W2036050012 @default.
- W2783000324 cites W2039793549 @default.
- W2783000324 cites W2040446598 @default.
- W2783000324 cites W2040827479 @default.
- W2783000324 cites W2041532314 @default.
- W2783000324 cites W2041617965 @default.
- W2783000324 cites W2044450846 @default.
- W2783000324 cites W2044614871 @default.
- W2783000324 cites W2045066522 @default.
- W2783000324 cites W2045389113 @default.
- W2783000324 cites W2046783953 @default.
- W2783000324 cites W2048467313 @default.
- W2783000324 cites W2056791786 @default.
- W2783000324 cites W2060672294 @default.
- W2783000324 cites W2063680739 @default.
- W2783000324 cites W2067958384 @default.
- W2783000324 cites W2069071003 @default.
- W2783000324 cites W2078791896 @default.
- W2783000324 cites W2080997194 @default.
- W2783000324 cites W2081003674 @default.
- W2783000324 cites W2083083094 @default.
- W2783000324 cites W2085692731 @default.
- W2783000324 cites W2090171472 @default.
- W2783000324 cites W2092052756 @default.
- W2783000324 cites W2092409918 @default.
- W2783000324 cites W2096287682 @default.
- W2783000324 cites W2096415778 @default.
- W2783000324 cites W2096758811 @default.
- W2783000324 cites W2101832993 @default.
- W2783000324 cites W2102152192 @default.
- W2783000324 cites W2105100844 @default.
- W2783000324 cites W2105949723 @default.
- W2783000324 cites W2107731988 @default.
- W2783000324 cites W2108671865 @default.
- W2783000324 cites W2112268717 @default.
- W2783000324 cites W2112345923 @default.
- W2783000324 cites W2114098415 @default.
- W2783000324 cites W2115862526 @default.
- W2783000324 cites W2117692326 @default.
- W2783000324 cites W2121935146 @default.
- W2783000324 cites W2124875378 @default.