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• W2783000541 abstract "For decades, proteases have been associated with cancer progression due to the ability of some members of this large group of enzymes to degrade tumor cell surroundings, thereby facilitating cancer invasion and dissemination. However, the generation of mouse models deficient in proteases has revealed the existence of a great variety of functions among proteolytic enzymes in cancer biology, including important tumor-suppressive roles. Therefore, in this chapter, we describe methods to chemically induce different types of cancer (lung adenocarcinoma, hepatocellular carcinoma, oral and esophageal carcinoma, colorectal carcinoma, skin cancer, and fibrosarcoma) in genetically modified mouse models to efficiently evaluate the specific pro- or antitumoral function of proteases in cancer." @default.
• W2783000541 created "2018-01-26" @default.
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• W2783000541 date "2018-01-01" @default.
• W2783000541 modified "2023-10-16" @default.
• W2783000541 title "Cancer Susceptibility Models in Protease-Deficient Mice" @default.
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• W2783000541 doi "https://doi.org/10.1007/978-1-4939-7595-2_21" @default.
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