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• W2783002244 abstract "Hepatocyte growth factor (HGF) and its receptor c-Met signaling have been implicated in regulating various types of cells including epithelial cells. We have previously reported that c-Met is expressed by thymic epithelial cells (TECs), and that in vivo administration of hybrid cytokines containing IL-7 and the beta- or alpha-chain of HGF significantly increase the number of TECs. In order to study the role of c-Met signaling in TECs, we generated conditional knockout (cKO) mice in which c-Met was specifically deleted in TECs using a Foxn1-Cre transgene. We show here that c-Met deficiency in TECs results in age-progressive reduction in TEC number and reduced number of regulatory T cells. Consequently, c-Met TEC cKO mice displayed an autoimmune phenotype. Thus, c-Met signaling in TECs is important for the maintenance of TECs and immune self-tolerance." @default.
• W2783002244 created "2018-01-26" @default.
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• W2783002244 date "2017-12-03" @default.
• W2783002244 modified "2023-09-28" @default.
• W2783002244 title "Targeted deletion of c-Met in thymic epithelial cells leads to an autoimmune phenotype" @default.
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• W2783002244 doi "https://doi.org/10.1111/imcb.1026" @default.
• W2783002244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5825253" @default.
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