FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783004715> ?p ?o ?g. }

• W2783004715 abstract "ABSTRACT G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in the DNA of human cells and other systems, where they play important biological roles, influencing processes such as telomere maintenance, DNA replication and transcription, or, in the case of RNA G-quadruplexes, RNA translation and processing. We report for the first time that DNA G-quadruplexes can be detected in the nuclei of the malaria parasite Plasmodium falciparum , which has one of the most A/T-biased genomes sequenced and therefore possesses few guanine-rich sequences with the potential to form G-quadruplexes. We show that despite this paucity of putative G-quadruplex-forming sequences, P. falciparum parasites are sensitive to several G-quadruplex-stabilizing drugs, including quarfloxin, which previously reached phase 2 clinical trials as an anticancer drug. Quarfloxin has a rapid initial rate of kill and is active against ring stages as well as replicative stages of intraerythrocytic development. We show that several G-quadruplex-stabilizing drugs, including quarfloxin, can suppress the transcription of a G-quadruplex-containing reporter gene in P. falciparum but that quarfloxin does not appear to disrupt the transcription of rRNAs, which was proposed as its mode of action in both human cells and trypanosomes. These data suggest that quarfloxin has potential for repositioning as an antimalarial with a novel mode of action. Furthermore, G-quadruplex biology in P. falciparum may present a target for development of other new antimalarial drugs." @default.
• W2783004715 created "2018-01-26" @default.
• W2783004715 creator A5007577995 @default.
• W2783004715 creator A5011624583 @default.
• W2783004715 creator A5021262946 @default.
• W2783004715 creator A5028052778 @default.
• W2783004715 creator A5032289255 @default.
• W2783004715 creator A5055651946 @default.
• W2783004715 creator A5060704586 @default.
• W2783004715 creator A5070093925 @default.
• W2783004715 date "2018-03-01" @default.
• W2783004715 modified "2023-09-27" @default.
• W2783004715 title "G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets" @default.
• W2783004715 cites W104999813 @default.
• W2783004715 cites W1450574606 @default.
• W2783004715 cites W1482546821 @default.
• W2783004715 cites W1943215114 @default.
• W2783004715 cites W1944863757 @default.
• W2783004715 cites W1969503178 @default.
• W2783004715 cites W1976529775 @default.
• W2783004715 cites W1978502771 @default.
• W2783004715 cites W1981991213 @default.
• W2783004715 cites W1984934469 @default.
• W2783004715 cites W1986738622 @default.
• W2783004715 cites W1989463861 @default.
• W2783004715 cites W1990635146 @default.
• W2783004715 cites W1997850371 @default.
• W2783004715 cites W2001564806 @default.
• W2783004715 cites W2007852671 @default.
• W2783004715 cites W2019851585 @default.
• W2783004715 cites W2020251171 @default.
• W2783004715 cites W2050321765 @default.
• W2783004715 cites W2050769764 @default.
• W2783004715 cites W2054547085 @default.
• W2783004715 cites W2056201880 @default.
• W2783004715 cites W2059306569 @default.
• W2783004715 cites W2076755375 @default.
• W2783004715 cites W2078863573 @default.
• W2783004715 cites W2100493498 @default.
• W2783004715 cites W2101792514 @default.
• W2783004715 cites W2102212065 @default.
• W2783004715 cites W2108763751 @default.
• W2783004715 cites W2111815242 @default.
• W2783004715 cites W2114168178 @default.
• W2783004715 cites W2114818342 @default.
• W2783004715 cites W2116273511 @default.
• W2783004715 cites W2119762097 @default.
• W2783004715 cites W2123282517 @default.
• W2783004715 cites W2137181004 @default.
• W2783004715 cites W2138586557 @default.
• W2783004715 cites W2151383900 @default.
• W2783004715 cites W2151510603 @default.
• W2783004715 cites W2155773930 @default.
• W2783004715 cites W2169431889 @default.
• W2783004715 cites W2169745877 @default.
• W2783004715 cites W2227700557 @default.
• W2783004715 cites W2337348577 @default.
• W2783004715 cites W2402321437 @default.
• W2783004715 cites W2547218633 @default.
• W2783004715 cites W2563319212 @default.
• W2783004715 cites W2592432046 @default.
• W2783004715 cites W2595631599 @default.
• W2783004715 cites W2738058938 @default.
• W2783004715 doi "https://doi.org/10.1128/aac.01828-17" @default.
• W2783004715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5826154" @default.
• W2783004715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29311059" @default.
• W2783004715 hasPublicationYear "2018" @default.
• W2783004715 type Work @default.
• W2783004715 sameAs 2783004715 @default.
• W2783004715 citedByCount "39" @default.
• W2783004715 countsByYear W27830047152018 @default.
• W2783004715 countsByYear W27830047152019 @default.
• W2783004715 countsByYear W27830047152020 @default.
• W2783004715 countsByYear W27830047152021 @default.
• W2783004715 countsByYear W27830047152022 @default.
• W2783004715 countsByYear W27830047152023 @default.
• W2783004715 crossrefType "journal-article" @default.
• W2783004715 hasAuthorship W2783004715A5007577995 @default.
• W2783004715 hasAuthorship W2783004715A5011624583 @default.
• W2783004715 hasAuthorship W2783004715A5021262946 @default.
• W2783004715 hasAuthorship W2783004715A5028052778 @default.
• W2783004715 hasAuthorship W2783004715A5032289255 @default.
• W2783004715 hasAuthorship W2783004715A5055651946 @default.
• W2783004715 hasAuthorship W2783004715A5060704586 @default.
• W2783004715 hasAuthorship W2783004715A5070093925 @default.
• W2783004715 hasBestOaLocation W27830047151 @default.
• W2783004715 hasConcept C104317684 @default.
• W2783004715 hasConcept C138885662 @default.
• W2783004715 hasConcept C179926584 @default.
• W2783004715 hasConcept C203014093 @default.
• W2783004715 hasConcept C24107716 @default.
• W2783004715 hasConcept C2778048844 @default.
• W2783004715 hasConcept C2778301229 @default.
• W2783004715 hasConcept C2778371730 @default.
• W2783004715 hasConcept C41895202 @default.
• W2783004715 hasConcept C512185932 @default.
• W2783004715 hasConcept C54355233 @default.
• W2783004715 hasConcept C552990157 @default.
• W2783004715 hasConcept C67705224 @default.
• W2783004715 hasConcept C70721500 @default.

• next