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• W2783005983 abstract "BACKGROUND:Spinal burst fractures are pathologies that occur in spinal injuries and cause significant mortality and morbidity as a result. Burst fractures in spinal cord injuries can result in rapid and significant oxidative stress. In addition to the primary injury in severe spinal cord injuries, subsequent secondary lesions are mainly due to inflammatory cascade activation and excessive production of free radicals. This study evaluated oxidative stress and antioxidant enzyme levels in burst fractures. MATERIAL AND METHODS:Twenty patients with burst fractures were diagnosed and underwent surgery and 20 healthy control subjects were included in the study. Neurological status was evaluated using the American Spine Injury Association Impairment Scale (ASIA) before and after surgery. Neurological function was scored as ASIA A: complete deficits, ASIA B–D: incomplete deficits, and ASIA E: neurologically intact. Spectrophotometry was performed to measure malondialdehyde (MDA) and low glutathione (GSH), glutathione peroxidase (GPx) levels, which represent lipid peroxide content. Evaluations were performed within 2 days after injury in the patients. RESULTS:MDA levels were higher in the burst fracture group (p<0.001), whereas GSH and SOD activities were higher in the control group (both p<0.001). There was no statistically significant difference in GPx levels between the groups (p=0.482). CONCLUSIONS:Oxidative stress appears to be related to burst fractures. Considering the importance of burst fractures in spinal cord injuries, a better understanding of these mechanisms may help in defining the role of oxidative stress after burst fractures. Prospective, randomized, controlled trials may reveal new therapeutic approaches that include antioxidants for explosive fractures focusing on oxidative stress." @default.
• W2783005983 created "2018-01-26" @default.
• W2783005983 creator A5048561736 @default.
• W2783005983 creator A5058929347 @default.
• W2783005983 date "2018-01-11" @default.
• W2783005983 modified "2023-09-30" @default.
• W2783005983 title "Evaluation of Oxidative Stress Levels and Antioxidant Enzyme Activities in Burst Fractures" @default.
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• W2783005983 doi "https://doi.org/10.12659/msm.908312" @default.
• W2783005983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5772452" @default.
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• W2783005983 hasPublicationYear "2018" @default.
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