Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783006952> ?p ?o ?g. }
- W2783006952 endingPage "304" @default.
- W2783006952 startingPage "294" @default.
- W2783006952 abstract "BACKGROUND:Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal (MG132), a peptide aldehyde proteasome inhibitor, can inhibit tumor progression by inactivating nuclear factor (NF)-κB signaling. Paclitaxel (PTX) is part of a routine regimen for the treatment of breast cancer. However, activation of the NF-κB pathway after treatment with PTX confers insensitivity to this drug. This study investigated the potential effect of MG132 as a co-treatment with PTX against breast cancer, and clarifies the underlying molecular mechanisms. MATERIAL AND METHODS:Breast cancer cells were treated with PTX, MG132, or PTX plus MG132, and the therapeutic effects were evaluated phenotypically. A mouse model of breast cancer was used to determine the combined effect of PTX plus MG132 in vivo. RESULTS:Treatment with PTX plus MG132 suppressed aggressive phenotypes of breast cancer cells more effectively than PTX alone. Consistently, MG132 also enhanced the suppressive effect of PTX on tumor growth in C57BL/6 mice. Significantly, activation of the NF-κB pathway by PTX was attenuated by MG132. CONCLUSIONS:Based on our findings, we suggest the application of MG132 in clinical practice in combination with PTX for the treatment of breast cancer." @default.
- W2783006952 created "2018-01-26" @default.
- W2783006952 creator A5022237512 @default.
- W2783006952 creator A5026198617 @default.
- W2783006952 creator A5028710085 @default.
- W2783006952 creator A5055072758 @default.
- W2783006952 creator A5063447635 @default.
- W2783006952 creator A5078484326 @default.
- W2783006952 date "2018-01-15" @default.
- W2783006952 modified "2023-10-16" @default.
- W2783006952 title "Proteasome Inhibitor Carbobenzoxy-L-Leucyl-L-Leucyl-L-Leucinal (MG132) Enhances Therapeutic Effect of Paclitaxel on Breast Cancer by Inhibiting Nuclear Factor (NF)-κB Signaling" @default.
- W2783006952 cites W128324155 @default.
- W2783006952 cites W1554632349 @default.
- W2783006952 cites W1564274931 @default.
- W2783006952 cites W178526765 @default.
- W2783006952 cites W1958512987 @default.
- W2783006952 cites W1970258245 @default.
- W2783006952 cites W1979385887 @default.
- W2783006952 cites W1983398917 @default.
- W2783006952 cites W1983771472 @default.
- W2783006952 cites W1995050066 @default.
- W2783006952 cites W2026561752 @default.
- W2783006952 cites W2029276835 @default.
- W2783006952 cites W2029715809 @default.
- W2783006952 cites W2035892035 @default.
- W2783006952 cites W2036770241 @default.
- W2783006952 cites W2045089316 @default.
- W2783006952 cites W2051994734 @default.
- W2783006952 cites W2054806474 @default.
- W2783006952 cites W2058473971 @default.
- W2783006952 cites W2068981042 @default.
- W2783006952 cites W2083230754 @default.
- W2783006952 cites W2084640577 @default.
- W2783006952 cites W2088698826 @default.
- W2783006952 cites W2089897767 @default.
- W2783006952 cites W2092875352 @default.
- W2783006952 cites W2094805273 @default.
- W2783006952 cites W2103133890 @default.
- W2783006952 cites W2106359723 @default.
- W2783006952 cites W2115732428 @default.
- W2783006952 cites W2127687001 @default.
- W2783006952 cites W2132570074 @default.
- W2783006952 cites W2135919558 @default.
- W2783006952 cites W2136863726 @default.
- W2783006952 cites W2147760686 @default.
- W2783006952 cites W2148947476 @default.
- W2783006952 cites W2169724245 @default.
- W2783006952 cites W2171949162 @default.
- W2783006952 cites W2288500425 @default.
- W2783006952 cites W2315613727 @default.
- W2783006952 cites W2560322684 @default.
- W2783006952 doi "https://doi.org/10.12659/msm.908139" @default.
- W2783006952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5779800" @default.
- W2783006952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29332931" @default.
- W2783006952 hasPublicationYear "2018" @default.
- W2783006952 type Work @default.
- W2783006952 sameAs 2783006952 @default.
- W2783006952 citedByCount "15" @default.
- W2783006952 countsByYear W27830069522018 @default.
- W2783006952 countsByYear W27830069522019 @default.
- W2783006952 countsByYear W27830069522020 @default.
- W2783006952 countsByYear W27830069522021 @default.
- W2783006952 countsByYear W27830069522023 @default.
- W2783006952 crossrefType "journal-article" @default.
- W2783006952 hasAuthorship W2783006952A5022237512 @default.
- W2783006952 hasAuthorship W2783006952A5026198617 @default.
- W2783006952 hasAuthorship W2783006952A5028710085 @default.
- W2783006952 hasAuthorship W2783006952A5055072758 @default.
- W2783006952 hasAuthorship W2783006952A5063447635 @default.
- W2783006952 hasAuthorship W2783006952A5078484326 @default.
- W2783006952 hasBestOaLocation W27830069522 @default.
- W2783006952 hasConcept C121608353 @default.
- W2783006952 hasConcept C126322002 @default.
- W2783006952 hasConcept C27740335 @default.
- W2783006952 hasConcept C2777292972 @default.
- W2783006952 hasConcept C2778367456 @default.
- W2783006952 hasConcept C2778506107 @default.
- W2783006952 hasConcept C502942594 @default.
- W2783006952 hasConcept C530470458 @default.
- W2783006952 hasConcept C71924100 @default.
- W2783006952 hasConcept C86803240 @default.
- W2783006952 hasConcept C95444343 @default.
- W2783006952 hasConcept C98274493 @default.
- W2783006952 hasConceptScore W2783006952C121608353 @default.
- W2783006952 hasConceptScore W2783006952C126322002 @default.
- W2783006952 hasConceptScore W2783006952C27740335 @default.
- W2783006952 hasConceptScore W2783006952C2777292972 @default.
- W2783006952 hasConceptScore W2783006952C2778367456 @default.
- W2783006952 hasConceptScore W2783006952C2778506107 @default.
- W2783006952 hasConceptScore W2783006952C502942594 @default.
- W2783006952 hasConceptScore W2783006952C530470458 @default.
- W2783006952 hasConceptScore W2783006952C71924100 @default.
- W2783006952 hasConceptScore W2783006952C86803240 @default.
- W2783006952 hasConceptScore W2783006952C95444343 @default.
- W2783006952 hasConceptScore W2783006952C98274493 @default.
- W2783006952 hasLocation W27830069521 @default.
- W2783006952 hasLocation W27830069522 @default.
- W2783006952 hasLocation W27830069523 @default.