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- W2783007124 abstract "Amyotrophic lateral sclerosis (ALS) is a complex disease, that affects the motor neuron circuitry. After consecutive failures in clinical trials for the past 20 years, edaravone was recently approved as the second drug for ALS. This generated excitement in the field revealed the need to improve preclinical assays for continued success. Here, we focus on the importance and relevance of upper motor neuron (UMN) pathology in ALS, and discuss how incorporation of UMN survival in preclinical assays will improve inclusion criteria for clinical trials and expedite the drug discovery effort in ALS and related motor neuron diseases." @default.
- W2783007124 created "2018-01-26" @default.
- W2783007124 creator A5070045262 @default.
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- W2783007124 date "2018-03-01" @default.
- W2783007124 modified "2023-09-27" @default.
- W2783007124 title "Incorporating upper motor neuron health in ALS drug discovery" @default.
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- W2783007124 doi "https://doi.org/10.1016/j.drudis.2018.01.027" @default.
- W2783007124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5849515" @default.
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