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• W2783007512 abstract "Increasing evidences suggest that the predator threat model is a valid animal model of post-traumatic stress disorder (PTSD). However, sleep has never been examined in this model. Since sleep disturbances, including insomnia and excessive daytime sleepiness, are severe and protracted symptoms of PTSD, we hypothesized that mice exposed to predator odor trauma (POT) will display contextual fear conditioning along with severe and protracted sleep disruptions. Adult male C57BL/6J mice, instrumented with wire electrodes (to record hippocampal local field potentials [LFP] and nuchal muscle [electromyogram, EMG] activity), were exposed to contextual conditioning using soiled cat litter as unconditional stimulus (US). On day 1, fear memory acquisition (FMA) training was performed by exposing mice to contextual cage (conditional stimulus; CS) for 30 min followed by exposure to CS + US for 90 min. On day 5, fear memory recall (FMR) testing was performed by exposing mice to CS (without US) for 120 min. LFP and EMG were recorded continuously for 5 days. Mice exposed to POT displayed as follows: (1) hyperarousal coupled with electrophysiological indicators of memory acquisition and retrieval (increased hippocampal θ and γ power) during FMA and FMR; (2) increased nonrapid eye movement (NREM) δ and rapid eye movement θ power during sleep post FMA, indicating memory consolidation; (3) protracted sleep disturbances as evident by increased wakefulness, reduced NREM sleep and NREM δ power, increased NREM β power during light (sleep) period, and increased sleep during dark (active) period. Based on these results, we suggest that mice exposed to POT display severe and protracted sleep disturbances mimicking sleep disturbance observed in human PTSD." @default.
• W2783007512 created "2018-01-26" @default.
• W2783007512 creator A5020910606 @default.
• W2783007512 creator A5022831401 @default.
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• W2783007512 date "2018-01-13" @default.
• W2783007512 modified "2023-10-11" @default.
• W2783007512 title "Severe and protracted sleep disruptions in mouse model of post-traumatic stress disorder" @default.
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• W2783007512 cites W1964204853 @default.
• W2783007512 cites W1970522097 @default.
• W2783007512 cites W1975221291 @default.
• W2783007512 cites W1975686642 @default.
• W2783007512 cites W1979189807 @default.
• W2783007512 cites W1980833896 @default.
• W2783007512 cites W1987327530 @default.
• W2783007512 cites W1990320386 @default.
• W2783007512 cites W1993432667 @default.
• W2783007512 cites W1994389924 @default.
• W2783007512 cites W1995523543 @default.
• W2783007512 cites W1996173637 @default.
• W2783007512 cites W1996400211 @default.
• W2783007512 cites W1996500337 @default.
• W2783007512 cites W1998119248 @default.
• W2783007512 cites W2001435497 @default.
• W2783007512 cites W2001484935 @default.
• W2783007512 cites W2004347871 @default.
• W2783007512 cites W2005079523 @default.
• W2783007512 cites W2005102053 @default.
• W2783007512 cites W2009397486 @default.
• W2783007512 cites W2012963042 @default.
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• W2783007512 cites W2013348995 @default.
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• W2783007512 cites W2018940622 @default.
• W2783007512 cites W2026836897 @default.
• W2783007512 cites W2033136528 @default.
• W2783007512 cites W2034326650 @default.
• W2783007512 cites W2040202620 @default.
• W2783007512 cites W2040886375 @default.
• W2783007512 cites W2043797519 @default.
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• W2783007512 cites W2049787235 @default.
• W2783007512 cites W2057484074 @default.
• W2783007512 cites W2064629564 @default.
• W2783007512 cites W2075308031 @default.
• W2783007512 cites W2076132050 @default.
• W2783007512 cites W2076245970 @default.
• W2783007512 cites W2079801189 @default.
• W2783007512 cites W2085757903 @default.
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• W2783007512 doi "https://doi.org/10.1093/sleep/zsy003" @default.
• W2783007512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29346627" @default.
• W2783007512 hasPublicationYear "2018" @default.
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