FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783008652> ?p ?o ?g. }

• W2783008652 endingPage "780" @default.
• W2783008652 startingPage "774" @default.
• W2783008652 abstract "To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and external beam radiation therapy (EBRT) in patients with intermediate-risk prostate cancer.A retrospective review was conducted in a prospectively collected database of patients with intermediate-risk prostate cancer who were treated either with brachytherapy or brachytherapy and EBRT, with or without androgen deprivation therapy (ADT), in the period 1990-2014. Urinary and erectile dysfunction symptoms were measured using the International Prostate Symptom Score (IPSS), the Mount Sinai erectile function scale and the Sexual Health Inventory for Men (SHIM). Cancer control endpoints included biochemical failure and development of distant metastases. All statistical analyses were carried out using the Statistical Package for Social Science (SPSS). Survival curves were calculated using Kaplan-Meier actuarial methods and compared using log-rank tests. Cox regression multivariate analyses were used to test the effect of multiple variables on treatment outcomes.A total of 902 patients were identified, with a median follow-up of 91 months. Of these, 390 received brachytherapy and 512 received combination therapy with EBRT. In patients with one intermediate-risk factor, the addition of EBRT did not significantly affect freedom from biochemical failure or distant metastases. Among patients with two or three intermediate-risk factors, added EBRT did not improve freedom from biochemical failure. Significant differences in late toxicity between patients treated with brachytherapy vs combination brachytherapy and EBRT were identified including urge incontinence (P < 0.001), haematuria (P < 0.001), dysuria (P < 0.001), and change in quality-of-life IPSS (P = 0.002). These symptoms were reported by patients at any point during treatment follow-up. Analysis of patients who were potent before treatment using actuarial methods showed that patients receiving combination therapy more frequently experienced loss of potency, as measured by the Mount Sinai erectile function scale (P = 0.040).Brachytherapy monotherapy results in equal biochemical and distant control in both patients with one and more than one intermediate-risk features. While no significant benefit was shown, we believe that the addition of EBRT may prevent recurrence in patients with multiple intermediate-risk features and should be considered." @default.
• W2783008652 created "2018-01-26" @default.
• W2783008652 creator A5008857530 @default.
• W2783008652 creator A5012386908 @default.
• W2783008652 creator A5012665897 @default.
• W2783008652 creator A5064904356 @default.
• W2783008652 date "2018-02-16" @default.
• W2783008652 modified "2023-09-22" @default.
• W2783008652 title "Outcomes and toxicities in patients with intermediate-risk prostate cancer treated with brachytherapy alone or brachytherapy and supplemental external beam radiation therapy" @default.
• W2783008652 cites W2025674066 @default.
• W2783008652 cites W2027840570 @default.
• W2783008652 cites W2040103703 @default.
• W2783008652 cites W2047513095 @default.
• W2783008652 cites W2074685353 @default.
• W2783008652 cites W2081447169 @default.
• W2783008652 cites W2082943541 @default.
• W2783008652 cites W2093867637 @default.
• W2783008652 cites W2114221591 @default.
• W2783008652 cites W2120455310 @default.
• W2783008652 cites W2139376731 @default.
• W2783008652 cites W2142438802 @default.
• W2783008652 cites W2148497849 @default.
• W2783008652 cites W2235523093 @default.
• W2783008652 cites W2443061927 @default.
• W2783008652 cites W2519027667 @default.
• W2783008652 cites W2524479840 @default.
• W2783008652 cites W2553678345 @default.
• W2783008652 cites W2625263844 @default.
• W2783008652 cites W2651727231 @default.
• W2783008652 cites W2729996436 @default.
• W2783008652 doi "https://doi.org/10.1111/bju.14128" @default.
• W2783008652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29319919" @default.
• W2783008652 hasPublicationYear "2018" @default.
• W2783008652 type Work @default.
• W2783008652 sameAs 2783008652 @default.
• W2783008652 citedByCount "11" @default.
• W2783008652 countsByYear W27830086522019 @default.
• W2783008652 countsByYear W27830086522020 @default.
• W2783008652 countsByYear W27830086522021 @default.
• W2783008652 countsByYear W27830086522022 @default.
• W2783008652 countsByYear W27830086522023 @default.
• W2783008652 crossrefType "journal-article" @default.
• W2783008652 hasAuthorship W2783008652A5008857530 @default.
• W2783008652 hasAuthorship W2783008652A5012386908 @default.
• W2783008652 hasAuthorship W2783008652A5012665897 @default.
• W2783008652 hasAuthorship W2783008652A5064904356 @default.
• W2783008652 hasBestOaLocation W27830086521 @default.
• W2783008652 hasConcept C121608353 @default.
• W2783008652 hasConcept C126322002 @default.
• W2783008652 hasConcept C126894567 @default.
• W2783008652 hasConcept C141071460 @default.
• W2783008652 hasConcept C143998085 @default.
• W2783008652 hasConcept C2775908122 @default.
• W2783008652 hasConcept C2777416452 @default.
• W2783008652 hasConcept C2777899217 @default.
• W2783008652 hasConcept C2780192828 @default.
• W2783008652 hasConcept C50382708 @default.
• W2783008652 hasConcept C509974204 @default.
• W2783008652 hasConcept C71924100 @default.
• W2783008652 hasConceptScore W2783008652C121608353 @default.
• W2783008652 hasConceptScore W2783008652C126322002 @default.
• W2783008652 hasConceptScore W2783008652C126894567 @default.
• W2783008652 hasConceptScore W2783008652C141071460 @default.
• W2783008652 hasConceptScore W2783008652C143998085 @default.
• W2783008652 hasConceptScore W2783008652C2775908122 @default.
• W2783008652 hasConceptScore W2783008652C2777416452 @default.
• W2783008652 hasConceptScore W2783008652C2777899217 @default.
• W2783008652 hasConceptScore W2783008652C2780192828 @default.
• W2783008652 hasConceptScore W2783008652C50382708 @default.
• W2783008652 hasConceptScore W2783008652C509974204 @default.
• W2783008652 hasConceptScore W2783008652C71924100 @default.
• W2783008652 hasFunder F4320309658 @default.
• W2783008652 hasIssue "5" @default.
• W2783008652 hasLocation W27830086521 @default.
• W2783008652 hasLocation W27830086522 @default.
• W2783008652 hasOpenAccess W2783008652 @default.
• W2783008652 hasPrimaryLocation W27830086521 @default.
• W2783008652 hasRelatedWork W2004529478 @default.
• W2783008652 hasRelatedWork W2030798726 @default.
• W2783008652 hasRelatedWork W2061131146 @default.
• W2783008652 hasRelatedWork W2149113979 @default.
• W2783008652 hasRelatedWork W2400503820 @default.
• W2783008652 hasRelatedWork W2753216329 @default.
• W2783008652 hasRelatedWork W2811098635 @default.
• W2783008652 hasRelatedWork W2913771305 @default.
• W2783008652 hasRelatedWork W2913927481 @default.
• W2783008652 hasRelatedWork W2921083113 @default.
• W2783008652 hasVolume "121" @default.
• W2783008652 isParatext "false" @default.
• W2783008652 isRetracted "false" @default.
• W2783008652 magId "2783008652" @default.
• W2783008652 workType "article" @default.