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- W2783011369 abstract "Oral drug delivery is the simplest and easiest way of administering drugs. Because of the greater stability, smaller bulk, accurate dosage and easy production, solid oral dosages forms have many advantages over other types of oral dosage forms. Therefore, most of the new chemical entities(NCE) under development these days are intended to be used as solid dosageform that originate an effective and reproducible in vivo plasma concentration after oral administration. It is concluded that the melting method and solvent evaporation method, are useful methods for the successful enhancement of solubility of poorly water soluble drug repaglinide with faster dissolution rate. But from the evidence of PXRD studies, the crystallinity of the drug was much reduced in SEM 7 compare to other 6 formulations. Further, it may be assumed that the bioavailability may be increased due to the conversion of crystalline matter into amorphous powder. Hence we can conclude that solid dispersions of repaglinide by using the water soluble carrier PVP K30 in the ratio 1:4 prepared by solvent evaporation method provide best drug release (100.2% released in30 mins) among all the selected 6 formulations, and this technique scan be used to enhance the bioavailability of poorly water soluble drugs like repaglinide." @default.
- W2783011369 created "2018-01-26" @default.
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- W2783011369 date "2011-10-01" @default.
- W2783011369 modified "2023-09-27" @default.
- W2783011369 title "Enhancement of Solubility of Repaglinide Through Solid Dispersion Methods" @default.
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