FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783011870> ?p ?o ?g. }

• W2783011870 abstract "Background: Rabbits are useful for preclinical studies of sinusitis because of similar physiologic features to humans. The objective of this study is to develop a rabbit model of sinusitis that permits assessment of microanatomy and sampling for evaluating shifts in the sinus microbiota during the development of sinusitis and to test how the mucociliary clearance (MCC) defect might lead to dysbiosis and chronic rhinosinusitis (CRS). Methods: Generation of CRS was accomplished with an insertion of a sterile sponge into the left middle meatus of New Zealand white rabbits (n = 9) for 2 weeks. After sponge removal, 4 rabbits were observed for another 10 weeks and evaluated for CRS using endoscopy, microCT, visualization of the functional micro-anatomy by micro-optical coherence tomography (μOCT), and histopathological analysis of the sinus mucosa. Samples were taken from the left middle meatus and submitted for microbiome analysis. Results: CT demonstrated opacification of all left sinuses at 2 weeks in all rabbits (n = 9), which persisted in animals followed for another 12 weeks (n = 4). Histology at week 2 showed mostly neutrophils. On week 14, significant infiltration of plasma cells and lymphocytes was noted with increased submucosal glands compared to controls (p = 0.02). Functional microanatomy at 2 weeks showed diminished periciliary layer (PCL) depth (p < 0.0001) and mucus transport (p = 0.0044) compared to controls despite a thick mucus layer. By 12 weeks, the thickened mucus layer was resolved but PCL depletion persisted in addition to decreased ciliary beat frequency (p < 0.0001). The mucin fermenting microbes (Lactobacillales, Bacteroidales) dominated on week 2 and there was a significant shift to potential pathogens (e.g. Pseudomonas, Burkholderia) by week 14 compared to both controls and the acute phase (p< 0.05). Conclusion: We anticipate this reproducible model will provide a means for identifying underlying mechanisms of airway-surface liquid (ASL) depletion and fundamental changes in sinus microbial communities that contribute to the development of CRS. The rabbit model of sinusitis exhibited diminished PCL depth with delayed mucus transport and significant alterations and shift in the sinus microbiome during the development of chronic inflammation." @default.
• W2783011870 created "2018-01-26" @default.
• W2783011870 creator A5000385368 @default.
• W2783011870 creator A5004952183 @default.
• W2783011870 creator A5014429496 @default.
• W2783011870 creator A5035736153 @default.
• W2783011870 creator A5036733807 @default.
• W2783011870 creator A5040550293 @default.
• W2783011870 creator A5054883733 @default.
• W2783011870 creator A5055664540 @default.
• W2783011870 creator A5061587101 @default.
• W2783011870 creator A5061603795 @default.
• W2783011870 date "2018-01-12" @default.
• W2783011870 modified "2023-10-16" @default.
• W2783011870 title "Sinus Microanatomy and Microbiota in a Rabbit Model of Rhinosinusitis" @default.
• W2783011870 cites W1485174478 @default.
• W2783011870 cites W1536821636 @default.
• W2783011870 cites W1600072873 @default.
• W2783011870 cites W1908398785 @default.
• W2783011870 cites W1922221875 @default.
• W2783011870 cites W1967821667 @default.
• W2783011870 cites W1976335033 @default.
• W2783011870 cites W1993804685 @default.
• W2783011870 cites W2004764283 @default.
• W2783011870 cites W2012247761 @default.
• W2783011870 cites W2013727782 @default.
• W2783011870 cites W2035664813 @default.
• W2783011870 cites W2043947497 @default.
• W2783011870 cites W2049271043 @default.
• W2783011870 cites W2068332307 @default.
• W2783011870 cites W2072970694 @default.
• W2783011870 cites W2076233967 @default.
• W2783011870 cites W2077691383 @default.
• W2783011870 cites W2080283023 @default.
• W2783011870 cites W2086268256 @default.
• W2783011870 cites W2086569637 @default.
• W2783011870 cites W2087537704 @default.
• W2783011870 cites W2090363313 @default.
• W2783011870 cites W2104318549 @default.
• W2783011870 cites W2117457769 @default.
• W2783011870 cites W2122157985 @default.
• W2783011870 cites W2123577868 @default.
• W2783011870 cites W2124351063 @default.
• W2783011870 cites W2129994723 @default.
• W2783011870 cites W2132963900 @default.
• W2783011870 cites W2145664556 @default.
• W2783011870 cites W2147637673 @default.
• W2783011870 cites W2148114189 @default.
• W2783011870 cites W2148970730 @default.
• W2783011870 cites W2152845123 @default.
• W2783011870 cites W2152885278 @default.
• W2783011870 cites W2154026962 @default.
• W2783011870 cites W2159162371 @default.
• W2783011870 cites W2160859910 @default.
• W2783011870 cites W2161466940 @default.
• W2783011870 cites W2165065263 @default.
• W2783011870 cites W2165067288 @default.
• W2783011870 cites W2168249366 @default.
• W2783011870 cites W2169855061 @default.
• W2783011870 cites W2171478721 @default.
• W2783011870 cites W2182177768 @default.
• W2783011870 cites W2219964339 @default.
• W2783011870 cites W2232970380 @default.
• W2783011870 cites W2295678160 @default.
• W2783011870 cites W2341975873 @default.
• W2783011870 cites W2344829056 @default.
• W2783011870 cites W2419223796 @default.
• W2783011870 cites W2487086229 @default.
• W2783011870 cites W2498147069 @default.
• W2783011870 cites W2508821329 @default.
• W2783011870 cites W2517382167 @default.
• W2783011870 cites W2523270036 @default.
• W2783011870 cites W2558524460 @default.
• W2783011870 cites W2561190091 @default.
• W2783011870 cites W2732522704 @default.
• W2783011870 cites W2755332593 @default.
• W2783011870 cites W2949852516 @default.
• W2783011870 cites W30236741 @default.
• W2783011870 doi "https://doi.org/10.3389/fcimb.2017.00540" @default.
• W2783011870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5770360" @default.
• W2783011870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29376039" @default.
• W2783011870 hasPublicationYear "2018" @default.
• W2783011870 type Work @default.
• W2783011870 sameAs 2783011870 @default.
• W2783011870 citedByCount "27" @default.
• W2783011870 countsByYear W27830118702019 @default.
• W2783011870 countsByYear W27830118702020 @default.
• W2783011870 countsByYear W27830118702021 @default.
• W2783011870 countsByYear W27830118702022 @default.
• W2783011870 countsByYear W27830118702023 @default.
• W2783011870 crossrefType "journal-article" @default.
• W2783011870 hasAuthorship W2783011870A5000385368 @default.
• W2783011870 hasAuthorship W2783011870A5004952183 @default.
• W2783011870 hasAuthorship W2783011870A5014429496 @default.
• W2783011870 hasAuthorship W2783011870A5035736153 @default.
• W2783011870 hasAuthorship W2783011870A5036733807 @default.
• W2783011870 hasAuthorship W2783011870A5040550293 @default.
• W2783011870 hasAuthorship W2783011870A5054883733 @default.
• W2783011870 hasAuthorship W2783011870A5055664540 @default.
• W2783011870 hasAuthorship W2783011870A5061587101 @default.

• next