FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783012184> ?p ?o ?g. }

• W2783012184 abstract "Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is also highly associated with autism spectrum disorders (ASD). It is caused by expansion of a CGG repeat sequence on the X chromosome resulting in silencing of the FMR1 gene. This is modeled in the mouse by deletion of Fmr1 (Fmr1 KO). Fmr1 KO mice recapitulate many of the behavioral features of the disorder including seizure susceptibility, hyperactivity, impaired social behavior, sleep problems, and learning and memory deficits. The mammalian target of rapamycin pathway (mTORC1) is upregulated in Fmr1 KO mice and is thought to be important for the pathogenesis of this disorder. We treated Fmr1 KO mice chronically with an mTORC1 inhibitor, rapamycin, to determine if rapamycin treatment could reverse behavioral phenotypes. We performed open field, zero maze, social behavior, sleep, passive avoidance, and audiogenic seizure testing. We found that p-S6 was upregulated in Fmr1 KO mice and normalized by rapamycin treatment, but, except for an anxiogenic effect, it did not reverse any of the behavioral phenotypes examined. In fact, rapamycin treatment had an adverse effect on sleep and social behavior in both control and Fmr1 KO mice. These results suggest that targeting the mTOR pathway in FXS is not a good treatment strategy and that other pathways should be considered." @default.
• W2783012184 created "2018-01-26" @default.
• W2783012184 creator A5000550919 @default.
• W2783012184 creator A5028361906 @default.
• W2783012184 creator A5029201284 @default.
• W2783012184 creator A5030108110 @default.
• W2783012184 creator A5036751583 @default.
• W2783012184 creator A5041406903 @default.
• W2783012184 creator A5065045271 @default.
• W2783012184 creator A5070318396 @default.
• W2783012184 date "2018-01-12" @default.
• W2783012184 modified "2023-10-14" @default.
• W2783012184 title "Negative Effects of Chronic Rapamycin Treatment on Behavior in a Mouse Model of Fragile X Syndrome" @default.
• W2783012184 cites W1552013470 @default.
• W2783012184 cites W1647335857 @default.
• W2783012184 cites W1962967416 @default.
• W2783012184 cites W1971718275 @default.
• W2783012184 cites W1976101979 @default.
• W2783012184 cites W1983698019 @default.
• W2783012184 cites W1989779456 @default.
• W2783012184 cites W2006926570 @default.
• W2783012184 cites W2023239280 @default.
• W2783012184 cites W2025130292 @default.
• W2783012184 cites W2035175869 @default.
• W2783012184 cites W2036681631 @default.
• W2783012184 cites W2038338205 @default.
• W2783012184 cites W2042310987 @default.
• W2783012184 cites W2043855339 @default.
• W2783012184 cites W2067872036 @default.
• W2783012184 cites W2071075776 @default.
• W2783012184 cites W2075620073 @default.
• W2783012184 cites W2076449621 @default.
• W2783012184 cites W2089756166 @default.
• W2783012184 cites W2092491372 @default.
• W2783012184 cites W2104582585 @default.
• W2783012184 cites W2111414408 @default.
• W2783012184 cites W2111444310 @default.
• W2783012184 cites W2117008929 @default.
• W2783012184 cites W2130431667 @default.
• W2783012184 cites W2132662156 @default.
• W2783012184 cites W2141296384 @default.
• W2783012184 cites W2147609603 @default.
• W2783012184 cites W2149919973 @default.
• W2783012184 cites W2152837277 @default.
• W2783012184 cites W2157742595 @default.
• W2783012184 cites W2158434083 @default.
• W2783012184 cites W2172091644 @default.
• W2783012184 cites W2217368851 @default.
• W2783012184 cites W2298522105 @default.
• W2783012184 cites W2323107141 @default.
• W2783012184 cites W2328976790 @default.
• W2783012184 cites W2337278288 @default.
• W2783012184 cites W2465376623 @default.
• W2783012184 cites W2521150881 @default.
• W2783012184 cites W2615129326 @default.
• W2783012184 cites W2744624838 @default.
• W2783012184 cites W2753664457 @default.
• W2783012184 doi "https://doi.org/10.3389/fnmol.2017.00452" @default.
• W2783012184 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5770365" @default.
• W2783012184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375310" @default.
• W2783012184 hasPublicationYear "2018" @default.
• W2783012184 type Work @default.
• W2783012184 sameAs 2783012184 @default.
• W2783012184 citedByCount "29" @default.
• W2783012184 countsByYear W27830121842018 @default.
• W2783012184 countsByYear W27830121842019 @default.
• W2783012184 countsByYear W27830121842020 @default.
• W2783012184 countsByYear W27830121842021 @default.
• W2783012184 countsByYear W27830121842022 @default.
• W2783012184 countsByYear W27830121842023 @default.
• W2783012184 crossrefType "journal-article" @default.
• W2783012184 hasAuthorship W2783012184A5000550919 @default.
• W2783012184 hasAuthorship W2783012184A5028361906 @default.
• W2783012184 hasAuthorship W2783012184A5029201284 @default.
• W2783012184 hasAuthorship W2783012184A5030108110 @default.
• W2783012184 hasAuthorship W2783012184A5036751583 @default.
• W2783012184 hasAuthorship W2783012184A5041406903 @default.
• W2783012184 hasAuthorship W2783012184A5065045271 @default.
• W2783012184 hasAuthorship W2783012184A5070318396 @default.
• W2783012184 hasBestOaLocation W27830121841 @default.
• W2783012184 hasConcept C104317684 @default.
• W2783012184 hasConcept C118552586 @default.
• W2783012184 hasConcept C127561419 @default.
• W2783012184 hasConcept C15744967 @default.
• W2783012184 hasConcept C169760540 @default.
• W2783012184 hasConcept C205778803 @default.
• W2783012184 hasConcept C2777630245 @default.
• W2783012184 hasConcept C2777949483 @default.
• W2783012184 hasConcept C2778538070 @default.
• W2783012184 hasConcept C2779063550 @default.
• W2783012184 hasConcept C2779085643 @default.
• W2783012184 hasConcept C3020422209 @default.
• W2783012184 hasConcept C54355233 @default.
• W2783012184 hasConcept C62478195 @default.
• W2783012184 hasConcept C71924100 @default.
• W2783012184 hasConcept C86554907 @default.
• W2783012184 hasConcept C86803240 @default.
• W2783012184 hasConcept C98490376 @default.
• W2783012184 hasConceptScore W2783012184C104317684 @default.
• W2783012184 hasConceptScore W2783012184C118552586 @default.

• next