FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783013315> ?p ?o ?g. }

• W2783013315 endingPage "117" @default.
• W2783013315 startingPage "117" @default.
• W2783013315 abstract "To evaluate BRAF, NRAS, and GNAQ mutations in surgical specimens of common and blue conjunctival melanocytic nevi.Surgical specimens from 25 conjunctival melanocytic nevi (23 common and 2 blue) of 25 patients were evaluated. All common nevi were analyzed immunohistochemically for the expression of BRAF V600E or NRAS Q61R. One lesion with negative immunoreactivity and for all blue nevi, a hybridization capture-based next-generation sequencing method was employed for mutation analysis. For common nevi, genetic features were compared with clinical and histopathologic findings. Continuous variables (age at excision and largest basal diameter) were compared with a Students's t-test and all categoric variables were compared with Fisher's Exact Test.Of common melanocytic nevi, 9 (39.1%) were immunoreactive for NRASQ61R and 13 (56.5%) were immunoreactive for BRAFV600E. One common nevus, which was immunonegative for both BRAFV600E and NRASQ61R was found to harbor an NRASQ61K mutation by sequence analysis. Patients with NRAS-mutated nevi were more likely to report occurrence of the lesion prior to 18-years old and more likely to have intrinsic cysts. The mean largest basal diameter was 6.0 and 3.5 mm for NRAS- and BRAF-immunoreactive lesions, respectively (P = 0.003). GNAQ mutations were identified in each of the two blue nevi of this study.These findings document that common conjunctival melanocytic nevi have mutually exclusive mutations in BRAF and NRAS. The two conjunctival blue nevi harbored GNAQ mutations. This suggests the driver mutations of conjunctival nevi are similar to those of nevi of the skin. At the molecular level, conjunctival nevi appear more like cutaneous nevi than choroidal nevi." @default.
• W2783013315 created "2018-01-26" @default.
• W2783013315 creator A5000886472 @default.
• W2783013315 creator A5019732504 @default.
• W2783013315 creator A5027415725 @default.
• W2783013315 creator A5044132232 @default.
• W2783013315 creator A5047847872 @default.
• W2783013315 creator A5057277785 @default.
• W2783013315 date "2018-01-16" @default.
• W2783013315 modified "2023-10-10" @default.
• W2783013315 title "<i>BRAF</i>, <i>NRAS</i>, and <i>GNAQ</i> Mutations in Conjunctival Melanocytic Nevi" @default.
• W2783013315 cites W1968690480 @default.
• W2783013315 cites W1970111539 @default.
• W2783013315 cites W1995936852 @default.
• W2783013315 cites W2027384688 @default.
• W2783013315 cites W2033470525 @default.
• W2783013315 cites W2053520756 @default.
• W2783013315 cites W2060573548 @default.
• W2783013315 cites W2066326640 @default.
• W2783013315 cites W2077517114 @default.
• W2783013315 cites W2080029881 @default.
• W2783013315 cites W2106123757 @default.
• W2783013315 cites W2107693762 @default.
• W2783013315 cites W2125970159 @default.
• W2783013315 cites W2131967786 @default.
• W2783013315 cites W2132865630 @default.
• W2783013315 cites W2134570345 @default.
• W2783013315 cites W2140514427 @default.
• W2783013315 cites W2162147276 @default.
• W2783013315 cites W2305655897 @default.
• W2783013315 cites W2327054228 @default.
• W2783013315 cites W2329548599 @default.
• W2783013315 cites W2426290616 @default.
• W2783013315 cites W2613362156 @default.
• W2783013315 doi "https://doi.org/10.1167/iovs.17-22517" @default.
• W2783013315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6110167" @default.
• W2783013315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29332123" @default.
• W2783013315 hasPublicationYear "2018" @default.
• W2783013315 type Work @default.
• W2783013315 sameAs 2783013315 @default.
• W2783013315 citedByCount "23" @default.
• W2783013315 countsByYear W27830133152018 @default.
• W2783013315 countsByYear W27830133152019 @default.
• W2783013315 countsByYear W27830133152020 @default.
• W2783013315 countsByYear W27830133152021 @default.
• W2783013315 countsByYear W27830133152022 @default.
• W2783013315 countsByYear W27830133152023 @default.
• W2783013315 crossrefType "journal-article" @default.
• W2783013315 hasAuthorship W2783013315A5000886472 @default.
• W2783013315 hasAuthorship W2783013315A5019732504 @default.
• W2783013315 hasAuthorship W2783013315A5027415725 @default.
• W2783013315 hasAuthorship W2783013315A5044132232 @default.
• W2783013315 hasAuthorship W2783013315A5047847872 @default.
• W2783013315 hasAuthorship W2783013315A5057277785 @default.
• W2783013315 hasBestOaLocation W27830133151 @default.
• W2783013315 hasConcept C104317684 @default.
• W2783013315 hasConcept C121608353 @default.
• W2783013315 hasConcept C126322002 @default.
• W2783013315 hasConcept C142724271 @default.
• W2783013315 hasConcept C16005928 @default.
• W2783013315 hasConcept C21790070 @default.
• W2783013315 hasConcept C2776294769 @default.
• W2783013315 hasConcept C2777658100 @default.
• W2783013315 hasConcept C2777972566 @default.
• W2783013315 hasConcept C2778024521 @default.
• W2783013315 hasConcept C2779176653 @default.
• W2783013315 hasConcept C2779306644 @default.
• W2783013315 hasConcept C2779323059 @default.
• W2783013315 hasConcept C2781187634 @default.
• W2783013315 hasConcept C501734568 @default.
• W2783013315 hasConcept C502942594 @default.
• W2783013315 hasConcept C526805850 @default.
• W2783013315 hasConcept C54355233 @default.
• W2783013315 hasConcept C71924100 @default.
• W2783013315 hasConcept C86803240 @default.
• W2783013315 hasConceptScore W2783013315C104317684 @default.
• W2783013315 hasConceptScore W2783013315C121608353 @default.
• W2783013315 hasConceptScore W2783013315C126322002 @default.
• W2783013315 hasConceptScore W2783013315C142724271 @default.
• W2783013315 hasConceptScore W2783013315C16005928 @default.
• W2783013315 hasConceptScore W2783013315C21790070 @default.
• W2783013315 hasConceptScore W2783013315C2776294769 @default.
• W2783013315 hasConceptScore W2783013315C2777658100 @default.
• W2783013315 hasConceptScore W2783013315C2777972566 @default.
• W2783013315 hasConceptScore W2783013315C2778024521 @default.
• W2783013315 hasConceptScore W2783013315C2779176653 @default.
• W2783013315 hasConceptScore W2783013315C2779306644 @default.
• W2783013315 hasConceptScore W2783013315C2779323059 @default.
• W2783013315 hasConceptScore W2783013315C2781187634 @default.
• W2783013315 hasConceptScore W2783013315C501734568 @default.
• W2783013315 hasConceptScore W2783013315C502942594 @default.
• W2783013315 hasConceptScore W2783013315C526805850 @default.
• W2783013315 hasConceptScore W2783013315C54355233 @default.
• W2783013315 hasConceptScore W2783013315C71924100 @default.
• W2783013315 hasConceptScore W2783013315C86803240 @default.
• W2783013315 hasIssue "1" @default.
• W2783013315 hasLocation W27830133151 @default.
• W2783013315 hasLocation W27830133152 @default.

• next