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- W2783013439 abstract "Tablet is a solid pharmaceutical dosage form containing drug substances with or without suitable diluents and prepared by compression or molding method. Drug delivery system (DDS) is a strategic tool for expanding markets/indications, extending product life cycles and generating opportunities. Oral administration is the most popular route for systemic effects due to its ease of ingestion, pain, avoidance, versatility and most importantly, patient compliance. Solid oral delivery systems are less expensive to manufacture, Patient compliance, high-precision dosing, and manufacturing efficiency make tablets the solid dosage form of choice. They do not require sterile conditions. Excipients and equipments choices will be significantly affected should solid dosage form technologies change in response to the unprecedented shifts in the drug discovery such as genomics.In-vitro release profile of tablets of all trials was satisfactory and drug release was achieved within 30 minutes Success of the In vitro drug release studies recommends the product for further in vivo studies, which may improve patient compliance from the literature Atorvastatin calcium, individual dosage form was used in the management of hyperlipidemia. Immediate release layer imparts rapid onset of action and regulates the body cholesterol and the results formulation F -5 has been selected as best formulation among all the other formulations. Formulation F – 5 provides better in vitro release. The formula optimized and it was selected for stability studies as per ICH guidelines and the formulation was found to be stable. Stability studies were conducted for F5 for 1st & 2nd month, which were found to be stable and concluded that formulation F5 was better stable product with good quality among the 5 formulation designed F5 formulation was considered to be the best formulation as it showed a similar dissolution profile similar to that of the innovator product LIPITOR." @default.
- W2783013439 created "2018-01-26" @default.
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- W2783013439 date "2013-04-01" @default.
- W2783013439 modified "2023-09-27" @default.
- W2783013439 title "Formulation and Evaluation of Atorvastatin Calcium Immediate Release Tablets Using Super Disintegrants." @default.
- W2783013439 hasPublicationYear "2013" @default.
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