FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783014736> ?p ?o ?g. }

• W2783014736 endingPage "100" @default.
• W2783014736 startingPage "100" @default.
• W2783014736 abstract "Purpose: We previously completed a comprehensive profile of the mouse lens transcriptome. Here, we investigate the proteome of the mouse lens through mass spectrometry–based protein sequencing at the same embryonic and postnatal time points. Methods: We extracted mouse lenses at embryonic day 15 (E15) and 18 (E18) and postnatal day 0 (P0), 3 (P3), 6 (P6), and 9 (P9). The lenses from each time point were preserved in three distinct pools to serve as biological replicates for each developmental stage. The total cellular protein was extracted from the lens, digested with trypsin, and labeled with isobaric tandem mass tags (TMT) for three independent TMT experiments. Results: A total of 5404 proteins were identified in the mouse ocular lens in at least one TMT set, 4244 in two, and 3155 were present in all three TMT sets. The majority of the proteins exhibited steady expression at all six developmental time points; nevertheless, we identified 39 proteins that exhibited an 8-fold differential (higher or lower) expression during the developmental time course compared to their respective levels at E15. The lens proteome is composed of diverse proteins that have distinct biological properties and functional characteristics, including proteins associated with cataractogenesis and autophagy. Conclusions: We have established a comprehensive profile of the developing murine lens proteome. This repository will be helpful in identifying critical components of lens development and processes essential for the maintenance of its transparency." @default.
• W2783014736 created "2018-01-26" @default.
• W2783014736 creator A5005372199 @default.
• W2783014736 creator A5048102822 @default.
• W2783014736 creator A5055842508 @default.
• W2783014736 creator A5063496375 @default.
• W2783014736 creator A5064985797 @default.
• W2783014736 creator A5081445006 @default.
• W2783014736 creator A5084826407 @default.
• W2783014736 creator A5085731729 @default.
• W2783014736 date "2018-01-13" @default.
• W2783014736 modified "2023-10-15" @default.
• W2783014736 title "Proteome Profiling of Developing Murine Lens Through Mass Spectrometry" @default.
• W2783014736 cites W116178826 @default.
• W2783014736 cites W1504075687 @default.
• W2783014736 cites W1523693806 @default.
• W2783014736 cites W1604522551 @default.
• W2783014736 cites W182703562 @default.
• W2783014736 cites W1969587863 @default.
• W2783014736 cites W1981337104 @default.
• W2783014736 cites W1983104893 @default.
• W2783014736 cites W1983937653 @default.
• W2783014736 cites W2015622779 @default.
• W2783014736 cites W2033213275 @default.
• W2783014736 cites W2036626722 @default.
• W2783014736 cites W2037279407 @default.
• W2783014736 cites W2056374307 @default.
• W2783014736 cites W2060051476 @default.
• W2783014736 cites W2075382919 @default.
• W2783014736 cites W2079557373 @default.
• W2783014736 cites W2080425802 @default.
• W2783014736 cites W2088354913 @default.
• W2783014736 cites W2089407911 @default.
• W2783014736 cites W2089715703 @default.
• W2783014736 cites W2090327760 @default.
• W2783014736 cites W2097109871 @default.
• W2783014736 cites W2116745204 @default.
• W2783014736 cites W2129265219 @default.
• W2783014736 cites W2135581618 @default.
• W2783014736 cites W2305149488 @default.
• W2783014736 cites W2336609683 @default.
• W2783014736 cites W2463081181 @default.
• W2783014736 cites W2463195069 @default.
• W2783014736 cites W2540687437 @default.
• W2783014736 cites W4210370525 @default.
• W2783014736 cites W4234586755 @default.
• W2783014736 cites W982172267 @default.
• W2783014736 doi "https://doi.org/10.1167/iovs.17-21601" @default.
• W2783014736 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5769801" @default.
• W2783014736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29332127" @default.
• W2783014736 hasPublicationYear "2018" @default.
• W2783014736 type Work @default.
• W2783014736 sameAs 2783014736 @default.
• W2783014736 citedByCount "21" @default.
• W2783014736 countsByYear W27830147362018 @default.
• W2783014736 countsByYear W27830147362019 @default.
• W2783014736 countsByYear W27830147362020 @default.
• W2783014736 countsByYear W27830147362021 @default.
• W2783014736 countsByYear W27830147362022 @default.
• W2783014736 countsByYear W27830147362023 @default.
• W2783014736 crossrefType "journal-article" @default.
• W2783014736 hasAuthorship W2783014736A5005372199 @default.
• W2783014736 hasAuthorship W2783014736A5048102822 @default.
• W2783014736 hasAuthorship W2783014736A5055842508 @default.
• W2783014736 hasAuthorship W2783014736A5063496375 @default.
• W2783014736 hasAuthorship W2783014736A5064985797 @default.
• W2783014736 hasAuthorship W2783014736A5081445006 @default.
• W2783014736 hasAuthorship W2783014736A5084826407 @default.
• W2783014736 hasAuthorship W2783014736A5085731729 @default.
• W2783014736 hasBestOaLocation W27830147361 @default.
• W2783014736 hasConcept C104317684 @default.
• W2783014736 hasConcept C104397665 @default.
• W2783014736 hasConcept C150194340 @default.
• W2783014736 hasConcept C151730666 @default.
• W2783014736 hasConcept C15336307 @default.
• W2783014736 hasConcept C153911025 @default.
• W2783014736 hasConcept C162317418 @default.
• W2783014736 hasConcept C162356407 @default.
• W2783014736 hasConcept C184185385 @default.
• W2783014736 hasConcept C185592680 @default.
• W2783014736 hasConcept C2909221355 @default.
• W2783014736 hasConcept C31827203 @default.
• W2783014736 hasConcept C43617362 @default.
• W2783014736 hasConcept C46111723 @default.
• W2783014736 hasConcept C55493867 @default.
• W2783014736 hasConcept C60644358 @default.
• W2783014736 hasConcept C68289359 @default.
• W2783014736 hasConcept C70721500 @default.
• W2783014736 hasConcept C7263354 @default.
• W2783014736 hasConcept C80311884 @default.
• W2783014736 hasConcept C86153913 @default.
• W2783014736 hasConcept C86803240 @default.
• W2783014736 hasConcept C95444343 @default.
• W2783014736 hasConceptScore W2783014736C104317684 @default.
• W2783014736 hasConceptScore W2783014736C104397665 @default.
• W2783014736 hasConceptScore W2783014736C150194340 @default.
• W2783014736 hasConceptScore W2783014736C151730666 @default.
• W2783014736 hasConceptScore W2783014736C15336307 @default.

• next