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• W2783017195 abstract "NKT cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy, however, greater understanding of iNKT cell biology is needed. The first step is to learn more about NKT development within the thymus. Recent studies suggest lineage separation of murine iNKT cells into iNKT1, iNKT2, and iNKT17 cells instead of shared developmental stages. This review will focus on these new studies and will discuss the evidence for lineage separation in contrast to shared developmental stages. I will also highlight the classifications of murine iNKT cells according to identified transcription factors and cytokine production, and I will discuss transcriptional and post-transcriptional regulations, and the role of mammalian target of rapamycin. Finally, the importance of these findings for human cancer therapy will be briefly discussed." @default.
• W2783017195 created "2018-01-26" @default.
• W2783017195 creator A5078461334 @default.
• W2783017195 date "2018-01-09" @default.
• W2783017195 modified "2023-10-10" @default.
• W2783017195 title "Unraveling Natural Killer T-Cells Development" @default.
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• W2783017195 doi "https://doi.org/10.3389/fimmu.2017.01950" @default.
• W2783017195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5767218" @default.
• W2783017195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29375573" @default.
• W2783017195 hasPublicationYear "2018" @default.
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