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- W2783017657 abstract "A wealth of literature exists regarding the pulmonary effects of ozone, a photochemical pollutant produced by the reaction of nitrogen oxide and volatile organic precursors in the presence of sunlight. This paper focuses on epidemiological panel studies and human clinical studies of ozone exposure, and discusses issues specific to this pollutant that may influence study design and interpretation as well as other, broader considerations relevant to ozone-health research. The issues are discussed using examples drawn from the wider literature. The recent panel and clinical literature is also reviewed. Health outcomes considered include lung function, symptoms, and pulmonary inflammation. Issues discussed include adversity, reversibility, adaptation, variability in ozone exposure metric used and health outcomes evaluated, co-pollutants in panel studies, influence of temperature in panel studies, and multiple comparisons. Improvements in and standardization of panel study approaches are recommended to facilitate comparisons between studies as well as meta-analyses. Additional clinical studies at or near the current National Ambient Air Quality Standard (NAAQS) of 70 ppb are recommended, as are clinical studies in sensitive subpopulations such as asthmatics.Implications: The pulmonary health impacts of ozone exposure have been well documented using both epidemiological and chamber study designs. However, there are a number of specific methodological and related issues that should be considered when interpreting the results of these studies and planning additional research, including the standardization of exposure and health metrics to facilitate comparisons among studies." @default.
- W2783017657 created "2018-01-26" @default.
- W2783017657 creator A5083736156 @default.
- W2783017657 date "2018-04-03" @default.
- W2783017657 modified "2023-09-24" @default.
- W2783017657 title "Ozone exposure and pulmonary effects in panel and human clinical studies: Considerations for design and interpretation" @default.
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- W2783017657 doi "https://doi.org/10.1080/10962247.2018.1424056" @default.
- W2783017657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29315024" @default.
- W2783017657 hasPublicationYear "2018" @default.
- W2783017657 type Work @default.