FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783021507> ?p ?o ?g. }

• W2783021507 abstract "Tumor-infiltrating immune cells are heterogeneous and consist of characteristic compartments, including T helper (Th)1 and regulatory T (Treg) cells that exhibit distinctive biological functions. The present study investigated the profile of infiltrating immune cells from surgically removed tumor tissues from patients with colorectal cancer. The characteristic transcription factors of Th1 and Th2 cells, Treg cells, Th17 cells and T follicular helper (Tfh) cells were analyzed. The results demonstrated that a marked increased number of Treg cells presented in tumor infiltrates when compared with non-tumor adjacent tissues. An increased number of Th1 and Tfh cells existed in tumor infiltrates compared with non-tumorous adjacent tissues, while the infiltration of Th17 and Th2 cells was similar between tumor and non-tumor adjacent tissues. Furthermore, there were an increased number of Treg cells in tumors with low infiltration compared with those with high infiltration. The expression of CXC motif chemokine (CXC) receptor 3, CXC ligand (CXCL)L9 and CXCL10 was significantly increased on infiltrating T cells in tumors with high infiltration as compared with those with low infiltration. Macrophages exhibited a dominant M2 phenotype in tumor infiltrates of colorectal cancer, whereas a balanced M1 and M2 phenotype presented in macrophages from the peripheral blood. In vitro stimulation of macrophages isolated from tumor tissue of colorectal cancer with granulocyte macrophage colony-stimulating factor and lipopolysaccharide did not drive to an inflammatory phenotype. The results provide insights into the pattern of immune cell infiltration in Chinese patients with colorectal cancer. It may be beneficial that patients with colorectal cancer are screened for the defined profile along with the expression of CXCL9 and CXCL10 in order to achieve better efficacy in clinical applications of immune-based therapy, including anti-programmed cell death protein 1 therapy." @default.
• W2783021507 created "2018-01-26" @default.
• W2783021507 creator A5014163967 @default.
• W2783021507 creator A5031767034 @default.
• W2783021507 creator A5037237721 @default.
• W2783021507 creator A5047701629 @default.
• W2783021507 creator A5069784670 @default.
• W2783021507 date "2018-01-10" @default.
• W2783021507 modified "2023-09-28" @default.
• W2783021507 title "Distinctive profiles of tumor-infiltrating immune cells and association with intensity of infiltration in colorectal cancer" @default.
• W2783021507 cites W1501547472 @default.
• W2783021507 cites W1576371692 @default.
• W2783021507 cites W1868820697 @default.
• W2783021507 cites W1923917571 @default.
• W2783021507 cites W1942388905 @default.
• W2783021507 cites W1965188145 @default.
• W2783021507 cites W1967369695 @default.
• W2783021507 cites W1970343639 @default.
• W2783021507 cites W1978259906 @default.
• W2783021507 cites W1981234314 @default.
• W2783021507 cites W1986736465 @default.
• W2783021507 cites W2020911016 @default.
• W2783021507 cites W2021175628 @default.
• W2783021507 cites W2061123122 @default.
• W2783021507 cites W2065210647 @default.
• W2783021507 cites W2070614384 @default.
• W2783021507 cites W2075735730 @default.
• W2783021507 cites W2078206835 @default.
• W2783021507 cites W2095724207 @default.
• W2783021507 cites W2103021272 @default.
• W2783021507 cites W2107277218 @default.
• W2783021507 cites W2123582755 @default.
• W2783021507 cites W2123640179 @default.
• W2783021507 cites W2128627731 @default.
• W2783021507 cites W2128640763 @default.
• W2783021507 cites W2129728624 @default.
• W2783021507 cites W2130111171 @default.
• W2783021507 cites W2133536768 @default.
• W2783021507 cites W2140520987 @default.
• W2783021507 cites W2140550585 @default.
• W2783021507 cites W2144304036 @default.
• W2783021507 cites W2147345889 @default.
• W2783021507 cites W2158081237 @default.
• W2783021507 cites W2163780874 @default.
• W2783021507 cites W2192080449 @default.
• W2783021507 cites W2202401513 @default.
• W2783021507 cites W2412151250 @default.
• W2783021507 doi "https://doi.org/10.3892/ol.2018.7771" @default.
• W2783021507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5795874" @default.
• W2783021507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29456737" @default.
• W2783021507 hasPublicationYear "2018" @default.
• W2783021507 type Work @default.
• W2783021507 sameAs 2783021507 @default.
• W2783021507 citedByCount "10" @default.
• W2783021507 countsByYear W27830215072018 @default.
• W2783021507 countsByYear W27830215072019 @default.
• W2783021507 countsByYear W27830215072020 @default.
• W2783021507 countsByYear W27830215072022 @default.
• W2783021507 countsByYear W27830215072023 @default.
• W2783021507 crossrefType "journal-article" @default.
• W2783021507 hasAuthorship W2783021507A5014163967 @default.
• W2783021507 hasAuthorship W2783021507A5031767034 @default.
• W2783021507 hasAuthorship W2783021507A5037237721 @default.
• W2783021507 hasAuthorship W2783021507A5047701629 @default.
• W2783021507 hasAuthorship W2783021507A5069784670 @default.
• W2783021507 hasBestOaLocation W27830215071 @default.
• W2783021507 hasConcept C121332964 @default.
• W2783021507 hasConcept C121608353 @default.
• W2783021507 hasConcept C126322002 @default.
• W2783021507 hasConcept C13373296 @default.
• W2783021507 hasConcept C142724271 @default.
• W2783021507 hasConcept C153400128 @default.
• W2783021507 hasConcept C17991360 @default.
• W2783021507 hasConcept C203014093 @default.
• W2783021507 hasConcept C502942594 @default.
• W2783021507 hasConcept C526805850 @default.
• W2783021507 hasConcept C5858377 @default.
• W2783021507 hasConcept C71924100 @default.
• W2783021507 hasConcept C86803240 @default.
• W2783021507 hasConcept C8891405 @default.
• W2783021507 hasConcept C96232424 @default.
• W2783021507 hasConcept C97355855 @default.
• W2783021507 hasConceptScore W2783021507C121332964 @default.
• W2783021507 hasConceptScore W2783021507C121608353 @default.
• W2783021507 hasConceptScore W2783021507C126322002 @default.
• W2783021507 hasConceptScore W2783021507C13373296 @default.
• W2783021507 hasConceptScore W2783021507C142724271 @default.
• W2783021507 hasConceptScore W2783021507C153400128 @default.
• W2783021507 hasConceptScore W2783021507C17991360 @default.
• W2783021507 hasConceptScore W2783021507C203014093 @default.
• W2783021507 hasConceptScore W2783021507C502942594 @default.
• W2783021507 hasConceptScore W2783021507C526805850 @default.
• W2783021507 hasConceptScore W2783021507C5858377 @default.
• W2783021507 hasConceptScore W2783021507C71924100 @default.
• W2783021507 hasConceptScore W2783021507C86803240 @default.
• W2783021507 hasConceptScore W2783021507C8891405 @default.
• W2783021507 hasConceptScore W2783021507C96232424 @default.
• W2783021507 hasConceptScore W2783021507C97355855 @default.
• W2783021507 hasLocation W27830215071 @default.
• W2783021507 hasLocation W27830215072 @default.

• next