FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783074748> ?p ?o ?g. }

• W2783074748 endingPage "305" @default.
• W2783074748 startingPage "296" @default.
• W2783074748 abstract "Recently, increasing evidence has indicated that the presence of tumor infiltrating immune cells has shown predictive significance for many solid tumors. Present study was performed to evaluate the predictive value of stromal tumor-infiltrating lymphocytes (TILs) for the presence of liver metastasis and overall survival in PDAC (pancreatic ductal adenocarcinoma) patients after complete resection and to explore the potential role of lymphocytes in PDAC. A total of 155 resectable patients with PDAC were enrolled in our study. Stromal TIL density was investigated in hematoxylin and eosin-stained sections of surgical specimens and scored. The effect and possible mechanism of lymphocytes on cancer cells was evaluated using co-culture techniques and ELISA test. Stromal TIL negative status (HR = 2.80, 95% CI 1.75-4.48, P < 0.01) was not only an independent predictor of worse OS (HR = 2.7, 95% CI 1.80-4.06, P = <0.01) but also a significant independent predictor of liver metastasis. Higher CEA (P = 0.01) or CA19-9 (P = 0.01) levels were associated with low stromal TIL density. Stromal TIL negative patients appeared to develop tumors with a higher CEA (P = 0.01), larger diameter (P = 0.05) and advanced stage (P = 0.02). The co-culture experiment suggests that lymphocytes can inhibit pancreatic cancer cell proliferation. Further ELISA and cell culture test indicate that lymphocytes may cause pancreatic cancer cells apoptosis through TNF-alpha secretion. Our data suggest a potential favorable role of stromal TILs in predicting liver metastasis and overall survival of patients with PDAC after complete resection. Lymphocytes may inhibit the growth of PDAC through TNF-alpha secretion, which suggest a potential therapeutic approach against PDAC." @default.
• W2783074748 created "2018-01-26" @default.
• W2783074748 creator A5044329598 @default.
• W2783074748 creator A5045421676 @default.
• W2783074748 creator A5066439685 @default.
• W2783074748 creator A5072756803 @default.
• W2783074748 creator A5086689827 @default.
• W2783074748 date "2018-02-22" @default.
• W2783074748 modified "2023-10-13" @default.
• W2783074748 title "The predictive value and role of stromal tumor-infiltrating lymphocytes in pancreatic ductal adenocarcinoma (PDAC)" @default.
• W2783074748 cites W1647507681 @default.
• W2783074748 cites W1827997917 @default.
• W2783074748 cites W1946106397 @default.
• W2783074748 cites W1974225259 @default.
• W2783074748 cites W1985213644 @default.
• W2783074748 cites W1987520066 @default.
• W2783074748 cites W2033166921 @default.
• W2783074748 cites W2041405668 @default.
• W2783074748 cites W2063569759 @default.
• W2783074748 cites W2071040214 @default.
• W2783074748 cites W2079548788 @default.
• W2783074748 cites W2109254024 @default.
• W2783074748 cites W2118796952 @default.
• W2783074748 cites W2120431466 @default.
• W2783074748 cites W2140883369 @default.
• W2783074748 cites W2155056339 @default.
• W2783074748 cites W2195541042 @default.
• W2783074748 cites W2225173575 @default.
• W2783074748 cites W2269536407 @default.
• W2783074748 cites W2297899744 @default.
• W2783074748 cites W2300584974 @default.
• W2783074748 cites W2319595593 @default.
• W2783074748 cites W2367901159 @default.
• W2783074748 cites W2391651292 @default.
• W2783074748 cites W2417322787 @default.
• W2783074748 cites W2486425508 @default.
• W2783074748 cites W2515648638 @default.
• W2783074748 cites W2521469434 @default.
• W2783074748 cites W2525725949 @default.
• W2783074748 cites W2529004149 @default.
• W2783074748 cites W2531056238 @default.
• W2783074748 cites W2567424265 @default.
• W2783074748 cites W2597872842 @default.
• W2783074748 cites W2741493642 @default.
• W2783074748 cites W4244578979 @default.
• W2783074748 doi "https://doi.org/10.1080/15384047.2017.1416932" @default.
• W2783074748 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5902243" @default.
• W2783074748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29313457" @default.
• W2783074748 hasPublicationYear "2018" @default.
• W2783074748 type Work @default.
• W2783074748 sameAs 2783074748 @default.
• W2783074748 citedByCount "29" @default.
• W2783074748 countsByYear W27830747482018 @default.
• W2783074748 countsByYear W27830747482019 @default.
• W2783074748 countsByYear W27830747482020 @default.
• W2783074748 countsByYear W27830747482021 @default.
• W2783074748 countsByYear W27830747482022 @default.
• W2783074748 crossrefType "journal-article" @default.
• W2783074748 hasAuthorship W2783074748A5044329598 @default.
• W2783074748 hasAuthorship W2783074748A5045421676 @default.
• W2783074748 hasAuthorship W2783074748A5066439685 @default.
• W2783074748 hasAuthorship W2783074748A5072756803 @default.
• W2783074748 hasAuthorship W2783074748A5086689827 @default.
• W2783074748 hasBestOaLocation W27830747481 @default.
• W2783074748 hasConcept C121608353 @default.
• W2783074748 hasConcept C125473707 @default.
• W2783074748 hasConcept C126322002 @default.
• W2783074748 hasConcept C142724271 @default.
• W2783074748 hasConcept C143998085 @default.
• W2783074748 hasConcept C16930146 @default.
• W2783074748 hasConcept C204232928 @default.
• W2783074748 hasConcept C2777701055 @default.
• W2783074748 hasConcept C2778326572 @default.
• W2783074748 hasConcept C2779013556 @default.
• W2783074748 hasConcept C2780210213 @default.
• W2783074748 hasConcept C2781182431 @default.
• W2783074748 hasConcept C502942594 @default.
• W2783074748 hasConcept C71924100 @default.
• W2783074748 hasConceptScore W2783074748C121608353 @default.
• W2783074748 hasConceptScore W2783074748C125473707 @default.
• W2783074748 hasConceptScore W2783074748C126322002 @default.
• W2783074748 hasConceptScore W2783074748C142724271 @default.
• W2783074748 hasConceptScore W2783074748C143998085 @default.
• W2783074748 hasConceptScore W2783074748C16930146 @default.
• W2783074748 hasConceptScore W2783074748C204232928 @default.
• W2783074748 hasConceptScore W2783074748C2777701055 @default.
• W2783074748 hasConceptScore W2783074748C2778326572 @default.
• W2783074748 hasConceptScore W2783074748C2779013556 @default.
• W2783074748 hasConceptScore W2783074748C2780210213 @default.
• W2783074748 hasConceptScore W2783074748C2781182431 @default.
• W2783074748 hasConceptScore W2783074748C502942594 @default.
• W2783074748 hasConceptScore W2783074748C71924100 @default.
• W2783074748 hasFunder F4320321001 @default.
• W2783074748 hasIssue "4" @default.
• W2783074748 hasLocation W27830747481 @default.
• W2783074748 hasLocation W27830747482 @default.
• W2783074748 hasLocation W27830747483 @default.
• W2783074748 hasLocation W27830747484 @default.

• next