FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783080503> ?p ?o ?g. }

• W2783080503 endingPage "15" @default.
• W2783080503 startingPage "1" @default.
• W2783080503 abstract "Increased expression levels of both mitochondrial citrate transporter (CTP) and plasma membrane citrate transporter (PMCT) proteins have been found in various cancers. The transported citrates by these two transporter proteins provide acetyl-CoA precursors for the de novo lipogenesis (DNL) pathway to support a high rate of cancer cell viability and development. Inhibition of the DNL pathway promotes cancer cell apoptosis without apparent cytotoxic to normal cells, leading to the representation of selective and powerful targets for cancer therapy. The present study demonstrates that treatments with CTP inhibitor (CTPi), PMCT inhibitor (PMCTi), and the combination of CTPi and PMCTi resulted in decreased cell viability in two hepatocellular carcinoma cell lines (HepG2 and HuH-7). Treatment with citrate transporter inhibitors caused a greater cytotoxic effect in HepG2 cells than in HuH-7 cells. A lower concentration of combined CTPi and PMCTi promotes cytotoxic effect compared with either of a single compound. An increased cell apoptosis and an induced cell cycle arrest in both cell lines were reported after administration of the combined inhibitors. A combination treatment exhibits an enhanced apoptosis through decreased intracellular citrate levels, which consequently cause inhibition of fatty acid production in HepG2 cells. Apoptosis induction through the mitochondrial-dependent pathway was found as a consequence of suppressed carnitine palmitoyl transferase-1 (CPT-1) activity and enhanced ROS generation by combined CTPi and PMCTi treatment. We showed that accumulation of malonyl-CoA did not correlate with decreasing CPT-1 activity. The present study showed that elevated ROS levels served as an inhibition on Bcl-2 activity that is at least in part responsible for apoptosis. Moreover, inhibition of the citrate transporter is selectively cytotoxic to HepG2 cells but not in primary human hepatocytes, supporting citrate-mediating fatty acid synthesis as a promising cancer therapy." @default.
• W2783080503 created "2018-01-26" @default.
• W2783080503 creator A5005152011 @default.
• W2783080503 creator A5012795625 @default.
• W2783080503 creator A5014561083 @default.
• W2783080503 creator A5040378376 @default.
• W2783080503 creator A5043318442 @default.
• W2783080503 creator A5046402797 @default.
• W2783080503 creator A5048289420 @default.
• W2783080503 creator A5069955189 @default.
• W2783080503 creator A5087561412 @default.
• W2783080503 date "2018-01-01" @default.
• W2783080503 modified "2023-10-17" @default.
• W2783080503 title "Combination of Mitochondrial and Plasma Membrane Citrate Transporter Inhibitors Inhibits De Novo Lipogenesis Pathway and Triggers Apoptosis in Hepatocellular Carcinoma Cells" @default.
• W2783080503 cites W1530264777 @default.
• W2783080503 cites W1675397952 @default.
• W2783080503 cites W1757407923 @default.
• W2783080503 cites W1760703658 @default.
• W2783080503 cites W1830948261 @default.
• W2783080503 cites W1868350448 @default.
• W2783080503 cites W1875710910 @default.
• W2783080503 cites W1883387268 @default.
• W2783080503 cites W1966452335 @default.
• W2783080503 cites W1968183669 @default.
• W2783080503 cites W1969734540 @default.
• W2783080503 cites W1974033486 @default.
• W2783080503 cites W1974428745 @default.
• W2783080503 cites W1974439644 @default.
• W2783080503 cites W1979938527 @default.
• W2783080503 cites W1980568044 @default.
• W2783080503 cites W1988764467 @default.
• W2783080503 cites W1990276200 @default.
• W2783080503 cites W1992110101 @default.
• W2783080503 cites W1999266780 @default.
• W2783080503 cites W2002194652 @default.
• W2783080503 cites W2012860378 @default.
• W2783080503 cites W2013051283 @default.
• W2783080503 cites W2014349355 @default.
• W2783080503 cites W2020195151 @default.
• W2783080503 cites W2030767845 @default.
• W2783080503 cites W2038237125 @default.
• W2783080503 cites W2040091217 @default.
• W2783080503 cites W2042605361 @default.
• W2783080503 cites W2043002642 @default.
• W2783080503 cites W2043396086 @default.
• W2783080503 cites W2044550149 @default.
• W2783080503 cites W2063487316 @default.
• W2783080503 cites W2064066603 @default.
• W2783080503 cites W2065261177 @default.
• W2783080503 cites W2065868087 @default.
• W2783080503 cites W2070923004 @default.
• W2783080503 cites W2076598575 @default.
• W2783080503 cites W2080998956 @default.
• W2783080503 cites W2084925682 @default.
• W2783080503 cites W2095987251 @default.
• W2783080503 cites W2097259163 @default.
• W2783080503 cites W2099192257 @default.
• W2783080503 cites W2104724110 @default.
• W2783080503 cites W2115627587 @default.
• W2783080503 cites W2115769549 @default.
• W2783080503 cites W2120613132 @default.
• W2783080503 cites W2124483853 @default.
• W2783080503 cites W2133817220 @default.
• W2783080503 cites W2135715116 @default.
• W2783080503 cites W2137642531 @default.
• W2783080503 cites W2138709778 @default.
• W2783080503 cites W2143408204 @default.
• W2783080503 cites W2146540050 @default.
• W2783080503 cites W2155457743 @default.
• W2783080503 cites W2160870282 @default.
• W2783080503 cites W2161970758 @default.
• W2783080503 cites W2163729820 @default.
• W2783080503 cites W2164514101 @default.
• W2783080503 cites W2186613797 @default.
• W2783080503 cites W2196123883 @default.
• W2783080503 cites W2199649852 @default.
• W2783080503 cites W2202672209 @default.
• W2783080503 cites W2237348612 @default.
• W2783080503 cites W2283429956 @default.
• W2783080503 cites W2324601854 @default.
• W2783080503 cites W2325292405 @default.
• W2783080503 cites W2396297323 @default.
• W2783080503 cites W2434847197 @default.
• W2783080503 cites W2515237216 @default.
• W2783080503 cites W2531111385 @default.
• W2783080503 cites W2557121453 @default.
• W2783080503 cites W2592290961 @default.
• W2783080503 cites W2592609855 @default.
• W2783080503 cites W2593237849 @default.
• W2783080503 cites W2607206893 @default.
• W2783080503 cites W2729327121 @default.
• W2783080503 cites W2737952479 @default.
• W2783080503 doi "https://doi.org/10.1155/2018/3683026" @default.
• W2783080503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5818947" @default.
• W2783080503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29546056" @default.
• W2783080503 hasPublicationYear "2018" @default.
• W2783080503 type Work @default.
• W2783080503 sameAs 2783080503 @default.

• next