FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2783087508> ?p ?o ?g. }

• W2783087508 endingPage "10" @default.
• W2783087508 startingPage "1" @default.
• W2783087508 abstract "Background: The neutrophils (PMN) are our main blood cells to combat fungi, bacteria, and fibrin. For normal function, an activated PMN generates a certain concentration of reactive oxygen species (ROS). If the generated blood ROS concentration is too low, then fungi, bacteria or fibrin might threaten the life of the patient, and it could be of great medical interest to stimulate PMN by physiologic drugs. Granulocyte-Colony Stimulating Factor (G-CSF) is a cell hormone that increases the cell number of PMN and that stimulates the individual PMN. The blood ROS generation assay (BRGA) is an innovative physiologic test to monitor the ROS generation of PMN in blood. Here the ROS generating action of G-CSF on normal PMN is quantified. Material and Methods: 40 μl 0 - 10.3 ng/ml (final conc.) G-CSF (in 5% human albumin) in black Brand? 781608 high quality polystyrene F-microwells was incubated in triplicate with 125 μl Hanks’ balanced salt solution (HBSS; modified without phenol red) and 10 μl normal citrated blood. Immediately (BRGA) or after 60 min (BRGA-60-) 10 μl 5 mM luminol sodium salt in 0.9% NaCl and 10 μl 0 or 36 μg/ml zymosan A in 0.9% NaCl was added. The photons were counted within 0 - 318 min (37°C) in a photons-multiplying microtiter plate luminometer. At about 0.5 t-maxn (0.5 fold the time to normal maximum) the approx. SC200 of G-CSF was determined. Results and Discussion: The approx. SC200 of G-CSF on normal blood ROS generation was 0.2 μg/l (=20 IU/ml). In clinical situations where an increased blood ROS generation is pharmacologically required, few micrograms of G-CSF could be a sufficient dosage for an adult patient. The BRGA helps to find out the correct stimulating G-CSF dosage for each individual. An enhanced PMN function could favor a better clinical outcome in situations of wanted increase of the innate immunology or in cellular fibrinolysis. G-CSF plasma concentrations of 0.1 - 1 μg/l might favor singlet oxygen generation without immunosuppression or cell fragment-induced thrombin generation." @default.
• W2783087508 created "2018-01-26" @default.
• W2783087508 creator A5032107121 @default.
• W2783087508 date "2018-01-01" @default.
• W2783087508 modified "2023-10-17" @default.
• W2783087508 title "Granulocyte Colony—Stimulating Factor Multiplies Normal Blood ROS Generation at Less than 1 &#181;g/l" @default.
• W2783087508 cites W12954242 @default.
• W2783087508 cites W1540576008 @default.
• W2783087508 cites W1553473844 @default.
• W2783087508 cites W1973079966 @default.
• W2783087508 cites W1985395658 @default.
• W2783087508 cites W1992040012 @default.
• W2783087508 cites W2010444443 @default.
• W2783087508 cites W2024398591 @default.
• W2783087508 cites W2027074599 @default.
• W2783087508 cites W2029085820 @default.
• W2783087508 cites W2038118874 @default.
• W2783087508 cites W2043327350 @default.
• W2783087508 cites W2046065003 @default.
• W2783087508 cites W2046966024 @default.
• W2783087508 cites W2048982730 @default.
• W2783087508 cites W2058042162 @default.
• W2783087508 cites W2066222426 @default.
• W2783087508 cites W2072884289 @default.
• W2783087508 cites W2076654877 @default.
• W2783087508 cites W2089806407 @default.
• W2783087508 cites W2117722432 @default.
• W2783087508 cites W2119998092 @default.
• W2783087508 cites W2123851168 @default.
• W2783087508 cites W2131301740 @default.
• W2783087508 cites W2154764032 @default.
• W2783087508 cites W2156479401 @default.
• W2783087508 cites W2157952919 @default.
• W2783087508 cites W2160810031 @default.
• W2783087508 cites W2166801917 @default.
• W2783087508 cites W2176847484 @default.
• W2783087508 cites W2255700465 @default.
• W2783087508 cites W2460426214 @default.
• W2783087508 doi "https://doi.org/10.4236/opj.2018.81001" @default.
• W2783087508 hasPublicationYear "2018" @default.
• W2783087508 type Work @default.
• W2783087508 sameAs 2783087508 @default.
• W2783087508 citedByCount "0" @default.
• W2783087508 crossrefType "journal-article" @default.
• W2783087508 hasAuthorship W2783087508A5032107121 @default.
• W2783087508 hasBestOaLocation W27830875081 @default.
• W2783087508 hasConcept C126322002 @default.
• W2783087508 hasConcept C153911025 @default.
• W2783087508 hasConcept C178790620 @default.
• W2783087508 hasConcept C185592680 @default.
• W2783087508 hasConcept C202751555 @default.
• W2783087508 hasConcept C203014093 @default.
• W2783087508 hasConcept C2776125364 @default.
• W2783087508 hasConcept C2776694085 @default.
• W2783087508 hasConcept C2777767877 @default.
• W2783087508 hasConcept C2777983669 @default.
• W2783087508 hasConcept C2778870864 @default.
• W2783087508 hasConcept C2778996431 @default.
• W2783087508 hasConcept C48349386 @default.
• W2783087508 hasConcept C54173615 @default.
• W2783087508 hasConcept C55493867 @default.
• W2783087508 hasConcept C71924100 @default.
• W2783087508 hasConcept C86803240 @default.
• W2783087508 hasConceptScore W2783087508C126322002 @default.
• W2783087508 hasConceptScore W2783087508C153911025 @default.
• W2783087508 hasConceptScore W2783087508C178790620 @default.
• W2783087508 hasConceptScore W2783087508C185592680 @default.
• W2783087508 hasConceptScore W2783087508C202751555 @default.
• W2783087508 hasConceptScore W2783087508C203014093 @default.
• W2783087508 hasConceptScore W2783087508C2776125364 @default.
• W2783087508 hasConceptScore W2783087508C2776694085 @default.
• W2783087508 hasConceptScore W2783087508C2777767877 @default.
• W2783087508 hasConceptScore W2783087508C2777983669 @default.
• W2783087508 hasConceptScore W2783087508C2778870864 @default.
• W2783087508 hasConceptScore W2783087508C2778996431 @default.
• W2783087508 hasConceptScore W2783087508C48349386 @default.
• W2783087508 hasConceptScore W2783087508C54173615 @default.
• W2783087508 hasConceptScore W2783087508C55493867 @default.
• W2783087508 hasConceptScore W2783087508C71924100 @default.
• W2783087508 hasConceptScore W2783087508C86803240 @default.
• W2783087508 hasIssue "01" @default.
• W2783087508 hasLocation W27830875081 @default.
• W2783087508 hasOpenAccess W2783087508 @default.
• W2783087508 hasPrimaryLocation W27830875081 @default.
• W2783087508 hasRelatedWork W1965000720 @default.
• W2783087508 hasRelatedWork W1987516811 @default.
• W2783087508 hasRelatedWork W2020403116 @default.
• W2783087508 hasRelatedWork W2029628372 @default.
• W2783087508 hasRelatedWork W2059936233 @default.
• W2783087508 hasRelatedWork W2077002620 @default.
• W2783087508 hasRelatedWork W2464609233 @default.
• W2783087508 hasRelatedWork W2465325657 @default.
• W2783087508 hasRelatedWork W2783087508 @default.
• W2783087508 hasRelatedWork W2182833133 @default.
• W2783087508 hasVolume "08" @default.
• W2783087508 isParatext "false" @default.
• W2783087508 isRetracted "false" @default.
• W2783087508 magId "2783087508" @default.

• next