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• W2783089968 endingPage "108" @default.
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• W2783089968 abstract "The gastrointestinal (GI) tract, in simplest terms, can be described as an epithelial-lined muscular tube extending along the cephalocaudal axis from the oral cavity to the anus. Although the general architecture of the GI tract organs is conserved from end to end, the presence of different epithelial tissue structures and unique epithelial cell types within each organ enables each to perform the distinct digestive functions required for efficient nutrient assimilation. Spatiotemporal regulation of signaling pathways and downstream transcription factors controls GI epithelial morphogenesis during development to confer essential regional-specific epithelial structures and functions. Here, we discuss the fundamental functions of each GI tract organ and summarize the diversity of epithelial structures present along the cephalocaudal axis of the GI tract. Next, we discuss findings, primarily from genetic mouse models, that have defined the roles of key transcription factors during epithelial morphogenesis, including p63, SOX2, SOX15, GATA4, GATA6, HNF4A, and HNF4G. Additionally, we examine how the Hedgehog, WNT, and BMP signaling pathways contribute to defining unique epithelial features along the cephalocaudal axis of the GI tract. Lastly, we examine the molecular mechanisms controlling regionalized cytodifferentiation of organ-specific epithelial cell types within the GI tract, concentrating on the stomach and small intestine. The delineation of GI epithelial patterning mechanisms in mice has provided fundamental knowledge to guide the development and refinement of three-dimensional GI organotypic culture models such as those derived from directed differentiation of human pluripotent stem cells and those derived directly from human tissue samples. Continued examination of these pathways will undoubtedly provide vital insights into the mechanisms of GI development and disease and may afford new avenues for innovative tissue engineering and personalized medicine approaches to treating GI diseases. • GI epithelial regionalization is necessary for efficient nutrient assimilation. • Regionalized functions require organ-specific epithelial structures and cell types. • This review examines essential pathways controlling GI epithelial regionalization." @default.
• W2783089968 created "2018-01-26" @default.
• W2783089968 creator A5015611755 @default.
• W2783089968 creator A5048781639 @default.
• W2783089968 creator A5064527665 @default.
• W2783089968 date "2018-03-01" @default.
• W2783089968 modified "2023-10-17" @default.
• W2783089968 title "Patterning the gastrointestinal epithelium to confer regional-specific functions" @default.
• W2783089968 cites W1482923899 @default.
• W2783089968 cites W1506515851 @default.
• W2783089968 cites W1534987406 @default.
• W2783089968 cites W1576726818 @default.
• W2783089968 cites W1581879249 @default.
• W2783089968 cites W1607596367 @default.
• W2783089968 cites W1632561034 @default.
• W2783089968 cites W1768073869 @default.
• W2783089968 cites W1787862415 @default.
• W2783089968 cites W1964526847 @default.
• W2783089968 cites W1966424854 @default.
• W2783089968 cites W1966681662 @default.
• W2783089968 cites W1966926802 @default.
• W2783089968 cites W1968157728 @default.
• W2783089968 cites W1968989675 @default.
• W2783089968 cites W1969770877 @default.
• W2783089968 cites W1974341178 @default.
• W2783089968 cites W1974369751 @default.
• W2783089968 cites W1974920067 @default.
• W2783089968 cites W1975401632 @default.
• W2783089968 cites W1977436879 @default.
• W2783089968 cites W1978841551 @default.
• W2783089968 cites W1981773624 @default.
• W2783089968 cites W1982533604 @default.
• W2783089968 cites W1982846641 @default.
• W2783089968 cites W1985967341 @default.
• W2783089968 cites W1986654088 @default.
• W2783089968 cites W1991592461 @default.
• W2783089968 cites W1991886741 @default.
• W2783089968 cites W1993677820 @default.
• W2783089968 cites W2003424014 @default.
• W2783089968 cites W2004761710 @default.
• W2783089968 cites W2006442535 @default.
• W2783089968 cites W2007788183 @default.
• W2783089968 cites W2008123286 @default.
• W2783089968 cites W2010807493 @default.
• W2783089968 cites W2011337131 @default.
• W2783089968 cites W2012364448 @default.
• W2783089968 cites W2012632470 @default.
• W2783089968 cites W2014487010 @default.
• W2783089968 cites W2014860961 @default.
• W2783089968 cites W2017060663 @default.
• W2783089968 cites W2018106351 @default.
• W2783089968 cites W2019156031 @default.
• W2783089968 cites W2021054542 @default.
• W2783089968 cites W2021847413 @default.
• W2783089968 cites W2023649138 @default.
• W2783089968 cites W2025727818 @default.
• W2783089968 cites W2030946124 @default.
• W2783089968 cites W2031190177 @default.
• W2783089968 cites W2032025006 @default.
• W2783089968 cites W2032638871 @default.
• W2783089968 cites W2033014144 @default.
• W2783089968 cites W2038747312 @default.
• W2783089968 cites W2045467715 @default.
• W2783089968 cites W2047563941 @default.
• W2783089968 cites W2048303910 @default.
• W2783089968 cites W2048849945 @default.
• W2783089968 cites W2050306701 @default.
• W2783089968 cites W2050610306 @default.
• W2783089968 cites W2054186703 @default.
• W2783089968 cites W2058125858 @default.
• W2783089968 cites W2059879159 @default.
• W2783089968 cites W2065121957 @default.
• W2783089968 cites W2065368961 @default.
• W2783089968 cites W2065546267 @default.
• W2783089968 cites W2065839331 @default.
• W2783089968 cites W2066801678 @default.
• W2783089968 cites W2067922543 @default.
• W2783089968 cites W2069058322 @default.
• W2783089968 cites W2070939204 @default.
• W2783089968 cites W2072287846 @default.
• W2783089968 cites W2073852580 @default.
• W2783089968 cites W2076540892 @default.
• W2783089968 cites W2079123437 @default.
• W2783089968 cites W2080342872 @default.
• W2783089968 cites W2085283665 @default.
• W2783089968 cites W2089117232 @default.
• W2783089968 cites W2090364972 @default.
• W2783089968 cites W2092407833 @default.
• W2783089968 cites W2096888542 @default.
• W2783089968 cites W2099874384 @default.
• W2783089968 cites W2100562940 @default.
• W2783089968 cites W2101403111 @default.
• W2783089968 cites W2103045139 @default.
• W2783089968 cites W2104521428 @default.
• W2783089968 cites W2104661934 @default.
• W2783089968 cites W2105002552 @default.
• W2783089968 cites W2106703676 @default.
• W2783089968 cites W2107601240 @default.

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