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• W2783100955 abstract "To assess the effect of low-molecular-weight polysaccharides from Agaricus blazei Murrill (ABP‑AW1) as an immunoadjuvant therapy for type 1 T‑helper (Th1) responses in tumorigenesis, C57BL/6 mice were inoculated subcutaneously with ovalbumin (E.G7‑OVA). After 3, 10 and 17 days, the mice were immunized with PBS, OVA alone, or OVA and ABP‑AW1, at low (50 µg), intermediate (100 µg) or high (200 µg) doses. Tumor growth was examined and compared among the groups, as were the following parameters: Splenocyte viability/proliferation, peripheral blood CD4+/CD8+ T cell ratio, serum OVA‑specific IgG1 and IgG2b, secretion of interleukin (IL)‑2 and interferon (IFN)‑γ, and IFN‑γ production on a single cell level from cultured splenocytes. Tumor growth in mice treated with OVA and ABP‑AW1 (100 or 200 µg) was significantly slower, compared with in the other groups at the same time-points. OVA with 100 or 200 µg ABP‑AW1 was associated with a higher number of total splenocytes, a higher ratio of peripheral blood CD4+/CD8+ T‑lymphocytes, higher serum levels of OVA‑specific Th1‑type antibody IgG2b and greater secretion of the Th1 cytokines IL‑1 and IFN‑γ from splenocytes. ABP‑AW1 is a promising immunoadjuvant therapy candidate, due to its ability to boost the Th1 immune response when co‑administered with a cancer vaccine intended to inhibit cancer progression." @default.
• W2783100955 created "2018-01-26" @default.
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• W2783100955 date "2018-01-15" @default.
• W2783100955 modified "2023-09-27" @default.
• W2783100955 title "Low-molecular-weight polysaccharides from Agaricus�blazei Murrill modulate the Th1 response in cancer immunity" @default.
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• W2783100955 doi "https://doi.org/10.3892/ol.2018.7794" @default.
• W2783100955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5796377" @default.
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