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• W2783102953 abstract "Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is the result of a combination of two types of spindles with distinct spindle dynamic behaviors in the developing airway epithelium. Fixed spindles follow the classic long-axis rule and establish their division orientation before metaphase. In contrast, rotating spindles do not strictly follow the long-axis rule and determine their division orientation during metaphase. By using both a cell-based mechanical model and stretching-lung-explant experiments, we showed that mechanical force can function as a regulatory signal in maintaining the stable ratio between fixed spindles and rotating spindles. Our findings demonstrate that mechanical forces, cell geometry, and oriented cell division function together in a highly coordinated manner to ensure normal airway tube morphogenesis." @default.
• W2783102953 created "2018-01-26" @default.
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• W2783102953 date "2018-02-01" @default.
• W2783102953 modified "2023-10-14" @default.
• W2783102953 title "Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis" @default.
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• W2783102953 doi "https://doi.org/10.1016/j.devcel.2017.12.013" @default.
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• W2783102953 hasPublicationYear "2018" @default.
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