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- W2783107274 abstract "Kopman et al 1 accidentally discovered that after the administration of nitroglycerin in the course of induction of anesthesia for cardiac surgery, some patients had surprisingly low Pao 2 values. Therefore, these investigators undertook a special study of the effect of nitroglycerin on arterial blood gases and hemodynamics in a group of patients with coronary heart disease. They examined 21 patients. Thirteen of these patients received morphine and scopolamine as a premedication when sublingual nitroglycerin was given. Eight patients did not receive premedication. In the 13 patients who received premedication, the Pao 2 level decreased from a mean of 65+13 to 55+11 mm Hg following the administration of nitroglycerin. In the eight patients who did not receive premedication, the mean value of 78±10 mm Hg decreased to 64±8 mm Hg. In both groups pH and Pco 2 values did not change. The study provided conclusive evidence that sublingual nitroglycerin adversely" @default.
- W2783107274 created "2018-01-26" @default.
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- W2783107274 date "1979-01-12" @default.
- W2783107274 modified "2023-09-24" @default.
- W2783107274 title "Hypoxemia from sublingual nitroglycerin" @default.
- W2783107274 doi "https://doi.org/10.1001/jama.241.2.166" @default.
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