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- W2783109504 abstract "Acute megakaryoblastic leukemia is an uncommon disease comprising <5% of cases of acute myeloid leukemia occurring in both adults and children. Hereby, we are reporting a case of congenital AML-M7 in the infants, presenting at 3 weeks of age. We used the bone marrow examination, bone biopsy, immunophenotyping (leukemia panel), and FISH for the diagnosis and management purpose. The mother of the patient noticed the following symptoms: progressive abdominal distention, irritability, fever, vomiting, and frequent loose stools in her child, over a period of one week. On further investigation findings were as follows: complete blood count Hb 6.7 mg/dL, total leukocyte count (TLC) 21,000/mm3, and platelet count 217,000/mm3. Bone marrow examination revealed 55% blasts, which were medium to large in size, with high N:C ratio, fine immature chromatin, and up to one prominent nucleolus. Bone biopsy report showed hypercellular marrow with increased numbers of blasts (42%) and moderate marrow fibrosis. On immunophenotyping, MPO, CD 13, CD 33, CD 34, and CD117 markers were positive, and HLA-DR, CD3, CD5, CD7, CD10, CD19, CD22, CD79a, and TdT markers were negative. A secondary immunophenotyping panel showed positivity for CD41a and CD61. Thus the diagnosis of acute megakaryoblastic leukemia was confirmed. FISH for BCR-ABL rearrangement showed positivity in 76% cells. Extensive review of the literature did not reveal much information on this rare case report, and to the best of our knowledge, this would be the probable first case report of BCR-ABL-positive congenital acute megakaryoblastic leukemia. With this report, we would like to create awareness regarding the unusual early presentation and encourage clinicians to keep a high index of suspicion of megakaryocytic leukemia even in the neonatal period." @default.
- W2783109504 created "2018-01-26" @default.
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- W2783109504 date "2018-01-01" @default.
- W2783109504 modified "2023-09-27" @default.
- W2783109504 title "173 First Reported Case of Congenital Ph’ Positive (BCR/ABL Rearrangement) Acute Megakaryoblastic Leukemia (AMKL) and Review of Literature" @default.
- W2783109504 doi "https://doi.org/10.1093/ajcp/aqx121.172" @default.
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